Is the Antiproteinuric Effect of Dipyridamole Hemodynamically Mediated?

Abstract

We studied the acute antiproteinuric and renal hemodynamic effect of dipyridamole 30–60 mg intravenously in 13 salt-depleted patients with the nephrotic syndrome of different etiology. Whereas mean arterial pressure did not change, a small fall in glomerular filtration rate with a concomitant fall in filtration fraction and a decrease in urinary protein loss occurred. The fall in filtration fraction was positively correlated with the fall in proteinuria. This suggests that the antiproteinuric effect of dipyridamole is at least partly due to an efferent vasodilation with a fall in intraglomerular capillary pressure.

Effects of a Nucleoside Transporter Inhibitor, Dilazep, on Renal Microcirculation in Rats.

“…The TGF mechanism plays an important role in the regulation of water, electrolytes and blood pressure. In young spontaneously hypertensive rats (SHR), TGF activity is augmented compared to that in age-matched Wistar Kyoto rats, suggesting that it may participate in the initiation and/or nephrotic patients (9) via mechanisms that involve preservation of the charge barrier of the glomerulus (6)(7)(8) and reduction in GFR (6,9). Dipyridamole has been shown to decrease GFR in dogs (10) and humans (9,11).…”

“…In young spontaneously hypertensive rats (SHR), TGF activity is augmented compared to that in age-matched Wistar Kyoto rats, suggesting that it may participate in the initiation and/or nephrotic patients (9) via mechanisms that involve preservation of the charge barrier of the glomerulus (6)(7)(8) and reduction in GFR (6,9). Dipyridamole has been shown to decrease GFR in dogs (10) and humans (9,11). This decrease in GFR, which in humans was accompanied by a fall in filtration fraction (FF) (9), seems to indicate a reduction in intraglomerular pressure via the vasodilatation of postglomerular efferent arterioles.…”

“…Dipyridamole has been shown to decrease GFR in dogs (10) and humans (9,11). This decrease in GFR, which in humans was accompanied by a fall in filtration fraction (FF) (9), seems to indicate a reduction in intraglomerular pressure via the vasodilatation of postglomerular efferent arterioles. While several reports have documented the renal hemodynamic effects of dilazep (6,12,13), the effects in renal microcirculation have not been investigated.…”

Antithrombotic Drug Therapy for IgA Nephropathy: A Meta Analysis of Randomized Controlled Trials

“…Third, they inhibit glomerular mesangial cell proliferation (36). Fourth, they can induce efferent renal vasodilitation, possibly through an increase in intrarenal adenosine (37). Only one study (14) assessed the effects of dipyridamole on proteinuria and it showed that dipyridamole was beneficial for proteinuria.…”

Treatment with Vasodilators and Crude Extract of <i>Ganoderma lucidum</i> Suppresses Proteinuria in Nephrosis with Focal Segmental Glomerulosclerosis

“…Therefore, it is plausible that suppression of proteinuria in this study is likely to be related to some of the aforementioned properties of the crude extract of G. lucidum . In addition, suppression of proteinuria may be partially effected by the dipyridamole and other vasodilators which is believed to be related to the correction of hemodynamic maladjustment in the renal microcirculation [10, 11]. …”