Is the Cluster Headache Local Mastocytic Diaethesis?

Prusínski, A; Liberski, P.O.

doi:10.1111/j.1526-4610.1979.hed1902102.x

Cited by 14 publications

(5 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of our own material (8), we can support these observations. Cuypers et al (17) failed to confirm Appenzeller's (15,16) as well as our own (6,7,8) data. One possible explanation for these discrepancies may be the times at which the biopsies were done.…”

Section: Discussioncontrasting

confidence: 53%

“…Another aspect of CBH is the presence of fibrin deposits accounting for the induration characteristic of these reactions (18). Our previous results however (7) failed to show any effector cells participating in immunologically-mediated skin reactions. In this respect, the proliferation of mast cells with the features of dissolution seemed to be an isolated phenomenon.…”

Section: Discussionmentioning

confidence: 66%

“…Previous studies from this laboratory (6,7,8) have documented an increased number of mast cells in biopsies taken from the site of pain within the temporal skin area. This phenomenon was not accompanied by proliferation of other cellular components.…”

Section: Introductionmentioning

confidence: 86%

See 2 more Smart Citations

Mast Cells in Cluster Headache. Ultrastructure, Release Pattern and Possible Pathogenetic Significance

Mirecka²

1984

Cephalalgia

View full text Add to dashboard Cite

Cluster headache remains a disease with almost totally unknown etiology and poorly understood pathogenesis. Some evidence has been presented to suggest that histamine released from mast cells might possibly be responsible for the initiation of pain attack. The authors present ultrastructural data concerning cutaneous mast cells in the painful region in patients suffering from cluster headache. The biopsies were taken between attacks in a bout. The fine structure of the mast cells (namely swollen granules, zones of decreased density, membrane-bound vesicles and granular fusion) are consistent with the dissolution pattern of secretion. The possible role of antidromic-reflex activation of the mast cells is also discussed.

show abstract

Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 66%

See 1 more Smart Citation

Mast Cells in Cluster Headache. Ultrastructure, Release Pattern and Possible Pathogenetic Significance

Mirecka²

1984

Cephalalgia

View full text Add to dashboard Cite

show abstract

“…It is encouraging to find that studies are now being conducted by several groups on the changes of the background terrain and of the local areas of headache. 16,17,18,19,20 This brings me to a consideration of migraine's connections with stress. There is much clinical observation to support the idea that the migraineur handles stressful events in an exaggerated or inappropriate manner.…”

mentioning

confidence: 99%

The Migraine Connection

Graham¹

1981

Headache

View full text Add to dashboard Cite

“…According to some reports, an increased number of mast cells was observed in the skin of the temporal region in cluster headache. 10 Electron microscopy showed that these mast cells become active during attacks of headache. 11 No mast cell membrane stabilizing drugs have so far been administered in the treatment of cluster headache.…”

mentioning

confidence: 99%

Ketotifen in the Treatment of Chronic Cluster Headache

Split¹,

Szmidt²,

Prusínski

et al. 1984

Headache

View full text Add to dashboard Cite

SYNOPSIS Based on observations indicating histamine release in cluster headache, Ketotifen was given to 15 patients suffering from a chronic form of this disease. The drug shows a mast cell membrane stabilizing action which proved effective in the treatment of bronchial asthma. It was administered in dosage of 1 mg 3 times daily for 8 weeks. Full remission was achieved in 8 patients. A considerable improvement was noted in 2 cases, a moderate improvement in 3, and only a slight improvement in 2 cases.

show abstract

Is the Cluster Headache Local Mastocytic Diaethesis?

Abstract: SYNOPSIS Mast cell counts from the skin over painful regions were obtained in cluster patients and compared to those from controls. A significantly higher count was found in the cluster group, and suggests a possible causal relationship.

Cited by 14 publications

References 3 publications

Mast Cells in Cluster Headache. Ultrastructure, Release Pattern and Possible Pathogenetic Significance

Mast Cells in Cluster Headache. Ultrastructure, Release Pattern and Possible Pathogenetic Significance

The Migraine Connection

Ketotifen in the Treatment of Chronic Cluster Headache

Contact Info

Product

Resources

About