Is the COPD assessment test (CAT) effective in demonstrating the systemic inflammation and other components in COPD?

Sarıoğlu, Nurhan; Hişmioğulları, Adnan Adil; Bilen, Çiğdem; Erel, Fuat

doi:10.1016/j.rppnen.2015.08.007

Cited by 13 publications

(12 citation statements)

References 34 publications

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“…Chronic Obstructive Pulmonary Disease (COPD) is one of those diseases in which HRQoL is affected and becoming a major environmental and public health issue [1]. Globally, COPD is considered a significant cause of mortality and morbidity across the modern world [2] [3]. COPD is likely to increase in the coming years due to higher smoking prevalence, aging populations in many countries, and the spreading of environmental pollutants [4].…”

Section: Introductionmentioning

confidence: 99%

Correlates and Predictors of Health-Related Quality of Life among Patients with COPD: An Integrative Review

Tabar¹,

Alshraideh²

2019

OJN

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Background: Health-related quality of life is an important outcome variable with COPD patients. Impaired health-related quality of life among COPD patients is closely related to various factors. There are many factors that predict the HRQoL and the correlation with other important variables. Predictors of health-related quality of life were debatable in the literature. Aim: This review aimed to describe the correlation with HRQoL and to explore the predictors of HRQoL among patients with COPD. Methods: An integrative review method was conducted. A search protocol was conducted using EBSCO, Pubmed, CINAHL, Ovid, ProQuest, Cochrane, and Google Scholar databases up to October 1, 2019. Results: The review results out of 30 articles that discuss the predictors of HRQoL and 22 articles that discuss the HRQoL correlations with other important variables. The HRQoL predictors are classified according to sociodemographic factors and clinical factors, and also, the correlation and prediction of HRQoL with anxiety, fatigue, and uncertainty. The results of this review showed controversies in predictors between the studies. The most retrieved predictors were age, educational level, comorbidities, socioeconomic status, FEV1% predicted, GOLD stages, and the number of hospitalizations. The variables of anxiety and fatigue were strongly correlated and predicted HRQoL. While uncertainty was not reported as a significant HRQoL predictor. Conclusion: This review provides support about reliable predictors than unreliable one although some predictors still need further research in different races and cultures. Future research is needed to explore whether uncertainty can predict HRQoL among patients with COPD.

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Section: Introductionmentioning

confidence: 99%

Correlates and Predictors of Health-Related Quality of Life among Patients with COPD: An Integrative Review

Tabar¹,

Alshraideh²

2019

OJN

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“…Further evidence for this may be inferred from the relatively high average age of the study population, the high proportion of smokers, and the CAT score results: 90% of participants had scores 10. Previous studies have demonstrated associations between increasing CAT score and airflow limitation or COPD severity [53][54][55][56] ; in addition, despite the nonspecific nature of the symptoms described by the CAT, significantly higher scores have been reported in individuals with airflow limitation characteristic of COPD than individuals without, and it has been suggested that the test may prove useful for case finding. 57,58 Data from 2 studies showed that the majority of individuals with airflow limitation have CAT scores > 7 58 ; more than 90% of the participants in the present study met this criterion.…”

Section: Discussionmentioning

confidence: 99%

Assessment of symptom burden and adherence to respiratory medications in individuals self-reporting a diagnosis of COPD within a community pharmacy setting

Bollmeier¹,

Seaton²,

Prosser³

et al. 2019

Journal of the American Pharmacists Association

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a b s t r a c tObjectives: Data on symptom burden or medication adherence in patients with chronic obstructive pulmonary disease (COPD) within a community pharmacy setting are limited. This study assessed symptom burden and adherence to respiratory medications in individuals reporting COPD, chronic bronchitis, or emphysema diagnoses visiting community pharmacies. Design: This cross-sectional study enrolled participants visiting 35 community pharmacies in Missouri (October 2016 to April 2017). Participants: Eligible participants (aged 40 years or more with a self-reported history of COPD, prescription for at least 1 COPD maintenance medication during the previous 12 months, and able to complete an English questionnaire) were identified from pharmacy dispensing records. Main outcome measures: Participants completed a questionnaire assessing demographics, clinical characteristics, health literacy, COPD Assessment Test (CAT) modified Medical Research Council (mMRC) dyspnea scale scores, and exacerbation history. Recent spirometry data were obtained, if available, from participants' physicians. COPD was classified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016 criteria. Medication adherence was assessed as proportion of days covered (PDC) from dispensing records. Results: Of 682 participants (mean age 63.0 years; 57% female) with available pharmacy data, 251 (36.8%) had available spirometry data. Most participants had mMRC scores 2 (60.9%) and CAT scores 10 (90.2%); 57.2% reported at least 2 moderate or 1 or more severe exacerbations within the previous 12 months. GOLD classifications varied depending on the scale used (mMRC vs. CAT); more participants were classified as group C/D than group A/B, with the highest proportion classified as group D (higher symptom burden and exacerbation risk). Mean PDC was 0.46 ± 0.37; only 28.7% of participants were adherent (PDC 80%) to at least 1 COPD maintenance medication. Conclusion: Individuals self-reporting a COPD diagnosis receiving respiratory medications from community pharmacies in Missouri have a high symptom burden and low medication adherence. Further research should determine reasons for low adherence and ways to reduce COPD symptoms.

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“…In regard to this aim, the MARKO questionnaire showed a higher sensitivity for early symptoms of future possible COPD than SGRQ or CAT, with high convergent validity correlation with these already validated COPD health status questionnaires. This high convergent validity correlation is also important because it shows specificity for respiratory disorders and could probably mean that it could be associated with already known features of CAT and SGRQ, showing association with many facets of COPD, like underlying inflammation, airway limitation, breathlessness, progression of disease, morbidity, and mortality (11-15). On the other hand, at least for the 18-item version, the results were not influenced by common comorbidities and concomitant treatment.…”

Section: Discussionmentioning

confidence: 99%

Development and the initial validation of a new self-administered questionnaire for an early detection of health status changes in smokers at risk for chronic obstructive pulmonary disease (MARKO questionnaire)

et al. 2016

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AimTo develop and do an initial validation of a new simple tool (self-administered questionnaire) that would be sensitive and specific enough to detect early changes in smokers leading to future development of chronic obstructive pulmonary disease (COPD).Methods224 consecutive participants (50.9% women), with mean ± standard deviation age of 52.3 ± 6.7 years, 37.5 ± 16.7 pack-years smoking history (85.8% active smokers), and no prior diagnosis of COPD were recruited. The MARKO questionnaire was self-administered twice; at the general practitioner's office and after 2-4 weeks at the tertiary care hospital. Participants were assessed for COPD by a pulmonologist after filling in a quality of life (QoL) questionnaires, history-taking, physical examination, lung function test, 6-minute walk test, and laboratory tests. They were divided into four subgroups: “healthy” smokers, symptomatic smokers, and smokers with mild and moderately severe COPD.ResultsPsychometric analyses indicated that the 18-item questionnaire had a very good internal consistency (Cronbach’s alpha = 0.91) and test-retest reliability for a four week period (ρc = 0.89, 95% confidence interval [CI] 0.85-0.92, Lin’s concordance). A significant correlations of MARKO scores were found with two QoL questionnaires; r = 0.69 (P < 0.001) and r = 0.81 (P < 0.001). Receiver operating characteristic curve analysis showed an area under the curve of 0.753 (95% CI 0.691-0.808, P < 0.001), with a sensitivity of 71.83% and specificity of 64.24% to discriminate “healthy” smokers from other subgroups.ConclusionBased on psychometric analyses and high convergent validity correlation with already validated QoL questionnaires, the newly developed MARKO questionnaire was shown to be a reliable self-administered short health status assessment tool.Trial registrationClinicaltrial.gov NCT01550679

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Is the COPD assessment test (CAT) effective in demonstrating the systemic inflammation and other components in COPD?

Abstract: Systemic inflammation persists in the stable period of COPD. CRP, one of the inflammation markers, was correlated with the CAT. Further studies are required to confirm the relationship between CAT and biomarkers.

Cited by 13 publications

References 34 publications

Correlates and Predictors of Health-Related Quality of Life among Patients with COPD: An Integrative Review

Correlates and Predictors of Health-Related Quality of Life among Patients with COPD: An Integrative Review

Assessment of symptom burden and adherence to respiratory medications in individuals self-reporting a diagnosis of COPD within a community pharmacy setting

Development and the initial validation of a new self-administered questionnaire for an early detection of health status changes in smokers at risk for chronic obstructive pulmonary disease (MARKO questionnaire)

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