Is the Dermal Papilla a Primary Target in Alopecia Areata?

Randall, Valerie A.; Nutbrown, Michael; Calver, N.S.; Parkin, SM; Hull, S.P. MacDonald; Cunliffe, W.J.

doi:10.1038/jid.1995.30

Cited by 7 publications

(3 citation statements)

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“…There is significant evidence supporting this theory. HF cells in AA show strongly positive MICA expression, while normal HFs, except for a small region in the proximal matrix, are usually MICA negative; this zone is suggested to be the primary site involved in AA . The MICA and NKG2D receptors are also involved in other autoimmune diseases such as rheumatoid arthritis and type I diabetes .…”

Section: What Causes Immune Privilege Collapse?mentioning

confidence: 99%

“…HF cells in AA show strongly positive MICA expression, while normal HFs, except for a small region in the proximal matrix, are usually MICA negative; this zone is suggested to be the primary site involved in AA. 49,87,88 The MICA and NKG2D receptors are also involved in other autoimmune diseases such as rheumatoid arthritis 89 and type I diabetes. 90,91 Genetic studies have also provided ancillary clues to the involvement of MICA, ULBP and antioxidant enzymes in the pathogenesis of AA.…”

Section: Local Disturbances In Hair Follicles As the Initiators Of Immentioning

confidence: 99%

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Alopecia areata: a review of disease pathogenesis

et al. 2018

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Section: What Causes Immune Privilege Collapse?mentioning

confidence: 99%

Section: Local Disturbances In Hair Follicles As the Initiators Of Immentioning

confidence: 99%

Alopecia areata: a review of disease pathogenesis

et al. 2018

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“…It was initially demonstrated that the blood of most AA patients contained auto‐antibodies to normal follicular and epidermal keratinocytes (115, 116) rather than to some abnormal antigen peculiar to alopecia. Antibodies to follicular constituents could play a role by attaching to normal follicles, but they may be secondary features produced when isolated cells from damaged follicles enter the blood (117).…”

Section: Aa and Humoral Immunitymentioning

confidence: 99%

Alopecia Areata: Clinical Perspective and an Insight into Pathogenesis

Sehgal

Jain

2003

The Journal of Dermatology

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IFN-γ-induced HLA-DR but not ICAM-1 expression on cultured dermal papilla cells is downregulated by TNF-α

König

Happle

Hoffmann

1997

Archives of Dermatological Research

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The immune response present in untreated alopecia areata (AA) is characterized by overexpression of ICAM-1 and MHC molecules on dermal papilla cells of affected hair follicles and by a distinct cytokine pattern. After successful treatment with the potent contact allergen diphenylcyclopropenone (DCP), adhesion molecules are downregulated and a reversed pattern of cytokines is expressed. To determine which cytokines may be involved in this process we studied the expression and modulation of ICAM-1 and MHC class I and II molecules on cultured dermal papilla cells. Scalp biopsies were obtained from healthy donors and dermal papillae were isolated. The cells were treated with various cytokines and prostanoids. The surface molecules were labeled with FITC-conjugated antibodies, and the expression levels were quantified by FACScan analysis. Incubation with IFN-gamma led to a time-dependent upregulation of the surface molecules studied. IL-1 beta and TNF-alpha synergistically increased the expression of ICAM-1, but they failed to induce MHC molecules. However, both cytokines significantly reduced the IFN-gamma-induced HLA-DR expression. Pretreatment of cells with the cyclooxygenase inhibitor diclofenac, prostanoids, IL-10 or TGF-beta 1 did not alter the constitutive or IFN-gamma-elicited expression of surface molecules. A neutralizing anti-IL-1 beta-antibody did not affect any cytokine-induced changes. We conclude that with regard to surface molecules we can partly initiate in vitro the situation of AA in vivo. Moreover, our results suggest that TNF-alpha, which is markedly increased under DCP treatment, might be an effector of the therapeutic response in AA.

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Is the Dermal Papilla a Primary Target in Alopecia Areata?

Cited by 7 publications

References 0 publications

Alopecia areata: a review of disease pathogenesis

Alopecia areata: a review of disease pathogenesis

Alopecia Areata: Clinical Perspective and an Insight into Pathogenesis

IFN-γ-induced HLA-DR but not ICAM-1 expression on cultured dermal papilla cells is downregulated by TNF-α

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