Is the early or delayed remote ischemic preconditioning the more effective from a microcirculatory and histological point of view in a rat model of partial liver ischemia-reperfusion?

Magyar, Zsuzsanna; Varga, Gábor; Mester, Anita; Ghanem, Souleiman; Somogyi, Viktória; Tanczos, Bence; Deák, Ádám; Bidiga, László; Pető, Károly; Németh, Norbert

doi:10.1590/s0102-865020180070000005

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…Moreover, RIPC (5 min ischemia/5 min reperfusion) reduced neutrophil activation and adhesion and TNF-α [66]. Controversial results have been described in a rat model in which RIPC protocol included 3 cycles of 10 min ischemia interspersed with 10 min of reperfusion periods [67]. Regarding the hemodynamic and microcirculatory alterations, RIPC protocol had beneficial effect; however, the histopathological findings were paradox [67,68].…”

Section: Ripc In Warm Ischemia Without Liver Resectionmentioning

confidence: 99%

“…Controversial results have been described in a rat model in which RIPC protocol included 3 cycles of 10 min ischemia interspersed with 10 min of reperfusion periods [67]. Regarding the hemodynamic and microcirculatory alterations, RIPC protocol had beneficial effect; however, the histopathological findings were paradox [67,68]. In addition to RIPC in the hind limb, when RIPC (5 min ischemia/5 min reperfusion) is applied in kidney, it has also been shown to protect liver against I/R injury, improving blood flow, histology, and redox-state [69].…”

Section: Ripc In Warm Ischemia Without Liver Resectionmentioning

confidence: 99%

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Ischemic Preconditioning Directly or Remotely Applied on the Liver to Reduce Ischemia-Reperfusion Injury in Resections and Transplantation

Cornide‐Petronio¹,

Jiménez‐Castro²,

Gracia‐Sancho³

et al. 2019

Liver Disease and Surgery [Working Title]

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Ischemia-reperfusion (I/R) injury is an important cause of liver damage occurring during surgical procedures. In liver resection, I/R causes post-operative transaminasemia and liver function failure. In liver transplantation, I/R causes graft dysfunction, ranging from biochemical abnormalities to primary non-function of the transplanted organ. Ischemic preconditioning is a surgical strategy to reduce the severity of I/R and improve post-operative outcomes by prior exposure to a brief period of vascular occlusion directly to the target organ or remotely to a distant vascular bed. This chapter aims to discuss the different ischemic preconditioning strategies in both liver resection surgery and liver transplantation. In addition, we will describe the differences of such surgical strategies in both steatotic and nonsteatotic livers in both preclinical experiments and clinical practice. Such information may be useful to guide the design of the effective ischemic preconditioning methods in the surgery of hepatic resections and liver transplantation.

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Section: Ripc In Warm Ischemia Without Liver Resectionmentioning

confidence: 99%

Section: Ripc In Warm Ischemia Without Liver Resectionmentioning

confidence: 99%

Ischemic Preconditioning Directly or Remotely Applied on the Liver to Reduce Ischemia-Reperfusion Injury in Resections and Transplantation

Cornide‐Petronio¹,

Jiménez‐Castro²,

Gracia‐Sancho³

et al. 2019

Liver Disease and Surgery [Working Title]

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“…Various studies have investigated the role of remote Ümit Alakuş 1 , Mehmet F. Can 2 , Fevzi Nuri Aydın 3 , Muharrem Öztaş 1 , İsmail H. Özerhan 2 , Talha Sarıgöz 4 , Abdurrahman Şimşek 1 , Yusuf Peker 1 Optimal time for remote ischemic preconditioning for liver protection in experimental major liver resection DOI: 10.4274/gulhane.galenos.2020.1369 IPC in several organs including the liver (8,9). However, there is no consensus on the mechanism responsible and the optimal timing of the method in the setting of liver surgery (10).…”

Section: Introductionmentioning

confidence: 99%

Optimal time for remote ischemic preconditioning for liver protection in experimental major liver resection

Alakuş¹,

Can²,

Aydın³

et al. 2021

GMJ

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Due to the liver's rich blood supply, the control of inflow is mandatory if major resection is being planned. In this regard, temporary portal triad clamping is widely used. However, ischemia-reperfusion injury (IRI) in the liver is inevitable following interruption. Remote ischemic preconditioning (IPC) was shown to ameliorate injury in the target organ in various animal models. This experimental animal study was conducted to determine optimal preconditioning frequency to use in liver surgery that promotes potential mediators associated with protection.Methods: Male Wistar-Albino rats (n=72) were divided into 8 groups. In group 1 (sham), only the left lobe of the liver was resected without any preconditioning. In group 2, the left lobe of the liver was resected using 30 min of portal triad clamping. In other groups, prior to resection using the same procedure with group 2, 6 different remote IPC protocols (5 to 10 min ischemia plus 10 to 20 min reperfusion) were applied by clamping the femoral artery. Serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) level analysis, liver function tests, and histological examination were performed using the TUNEL staining to study apoptosis.Results: Compared to group 2, serum serum TNF-α and IL-6 level analysis and liver function tests did not show any difference. There was also no difference between the intervention groups and controls in histopathologic examination and apoptotic cell counts. Conclusions:Remote IPC protocols we studied in this experiment did not blunt hepatic IRI in rodents.

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“…Intraoperative blood loss has been encountered in liver surgeries including resection and transplantation. It is a life-threatening condition that could be managed temporarily by clamping the portal triad and this may result inadvertently to a process of ischemia following by a reperfusion phase which exacerbates the hepatic injury depending on the duration of the two phases [1,2].…”

Section: Introductionmentioning

confidence: 99%

Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury

2020

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Remote renal injury is a drastic consequence of hepatic ischemia/reperfusion (IR) injury. Vildagliptin (V) is a dipeptidyl peptidase-4 inhibitor that has a hepatorenal protective effect against models of liver and renal IR. This research was done to explore the protective role of vildagliptin against renal injury following hepatic IR injury as well as the possible involvement of transforming growth factor-beta (TGF-b)/Smad/alpha-smooth muscle actin (a-SMA) expressions in the pathophysiological mechanism of the remote renal injury. Three groups of male Wistar rats were organized into: sham group, IR group, and V þ IR group in which 10 mg/kg/day of vildagliptin was pretreated for 10 days intraperitoneally. Blood in addition to renal and hepatic tissue samples was used for biochemical and histopathological studies. Hepatic IR induced a marked increase in serum creatinine, blood urea nitrogen, liver enzymes, renal nitric oxide, malondialdehyde, tumor necrosis factor-alpha levels with a marked upregulation of renal mRNA expressions of TGF-b, Smad2, Smad3, and a-SMA in addition to a marked decline in renal catalase content comparing to the sham group. Abnormal histopathological findings of hepatic and renal injury were detected in the IR group. Vildagliptin significantly improved these biochemical markers as well as the histopathological changes. The upregulation of renal TGF-b/Smad/a-SMA mRNA expressions was involved for the first time in the pathogenesis of the renal injury following hepatic IR and vildagliptin ameliorated this renal injury through blocking these expressions.

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Is the early or delayed remote ischemic preconditioning the more effective from a microcirculatory and histological point of view in a rat model of partial liver ischemia-reperfusion?

Abstract: Considering the survival and the results, both remote ischemic preconditioning protocols had beneficial effect in hepatic ischemia-reperfusion, however the histopathological findings were controversial.

Cited by 6 publications

References 32 publications

Ischemic Preconditioning Directly or Remotely Applied on the Liver to Reduce Ischemia-Reperfusion Injury in Resections and Transplantation

Ischemic Preconditioning Directly or Remotely Applied on the Liver to Reduce Ischemia-Reperfusion Injury in Resections and Transplantation

Optimal time for remote ischemic preconditioning for liver protection in experimental major liver resection

Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury

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