Is the horse a reservoir or an indicator of Coxiella burnetii infection? Systematic review and biomolecular investigation

Marenzoni, Maria Luisa; Stefanetti, Valentina; Papa, Paola; Proietti, Patrizia Casagrande; Bietta, Annalisa; Mauro, Coletti; Passamonti, Fabrizio; Henning, Klaus

doi:10.1016/j.vetmic.2013.09.027

Cited by 23 publications

(26 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These non‐livestock species also experience clinical abortion associated with this organism and, zoonotic disease has ensued . Infected horses, mules and donkeys in rare cases can abort . C. burnetii shedding has been described in many species of wild animals commonly encountered on farms, including wild migratory and nonmigratory birds .…”

Section: Control Of Coxiellosismentioning

confidence: 99%

Management of Coxiella burnetii infection in livestock populations and the associated zoonotic risk: A consensus statement

Plummer

McClure

Menzies

et al. 2018

Veterinary Internal Medicne

View full text Add to dashboard Cite

Infections caused by Coxiella burnetii, commonly referred to as coxiellosis when occurring in animals and Query fever when occurring in humans, are an important cause of abortions, decreased reproductive efficiency, and subclinical infections in ruminants. The organism also represents an important zoonotic concern associated with its ability to aerosolize easily and its low infectious dose. Available diagnostic tests have limited sensitivity, which combined with the absence of treatment options in animals and limited approaches to prevention, result in difficulty managing this agent for optimal animal health and zoonotic disease outcomes. The purpose of this consensus statement is to provide veterinarians and public health officials with a summary of the available information regarding management of C. burnetii infection in livestock populations. A discussion of currently available testing options and their interpretation is provided, along with recommendations on management practices that can be implemented on‐farm in the face of an outbreak to mitigate losses. Emphasis is placed on biosecurity measures that can be considered for minimizing the zoonotic transmission risk in both field and veterinary facilities.

show abstract

Section: Control Of Coxiellosismentioning

confidence: 99%

Management of Coxiella burnetii infection in livestock populations and the associated zoonotic risk: A consensus statement

Plummer

McClure

Menzies

et al. 2018

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Une séroprévalence moyenne de 15,8 % a été calculée à partir des études publiées dans la littérature, ce qui est comparable aux séroprévalences rapportées dans d'autres espèces, notamment les ruminants. Il faud-rait donc également tenir compte du rôle possible du cheval comme réservoir pour d'autres espèces animales, y compris l'humain (Marenzoni et al 2013). Aux Pays-Bas, la présence de la bactérie chez certains chiens et chevaux indique que ces derniers devraient être considérés comme réservoirs de C. burnetii (Roest et al 2013b).…”

Section: Les Réservoirsunclassified

Coxiella burnetii, agent de la fièvre Q

Boarbi¹,

Frétin²,

Mori³

2016

Can. J. Microbiol.

View full text Add to dashboard Cite

Résumé : La fièvre Q est une zoonose de répartition mondiale excepté la Nouvelle-Zélande. Elle est due à une bactérie intracellulaire : Coxiella burnetii. Cette infection passe souvent inaperçue car la manifestation principale de la forme aiguë de la maladie est un syndrome pseudogrippal spontanément résolutif. C'est l'épidémie qui a eu lieu aux Pays-Bas qui a attiré l'attention sur cette maladie qui était moins étudiée auparavant. Cette synthèse résume la description de la bactérie (taxonomie, cycle intracellulaire et génomique) mais également la maladie (description, diagnostic, pathogénie et épidémiologie). Enfin, la vaccination de l'humain et des animaux est également analysée. Mots-clés : Coxiella burnetii, fièvre Q, épidémiologie, description, génomique.Abstract: Q fever is a zoonosis of worldwide distribution with the exception of New Zealand. It is caused by an intracellular bacterium, Coxiella burnetii. The disease often goes underdiagnosed because the main manifestation of its acute form is a general self-limiting flu-like syndrome. The Dutch epidemics renewed attention to this disease, which was less considered before. This review summarizes the description of C. burnetii (taxonomy, intracellular cycle, and genome) and Q fever disease (description, diagnosis, epidemiology, and pathogenesis). Finally, vaccination in humans and animals is also considered.

show abstract

“…Human outbreaks are generally associated with the presence of livestock, but infections may also occasionally be associated with other domestic or wild species (EFSA, 2010;Gonzalez-Barrio et al, 2015;Lang, 1990;Marenzoni et al, 2013;Maurin and Raoult, 1999;Stein and Raoult, 1999). Q fever cases have also been reported in horseback riders or people visiting horse facilities, but the source of contamination was likely either small ruminants or ticks present in the horses' environment (Nett et al, 2012;Roest et al, 2013;Runge et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…A few studies have also mentioned that people working with horses, like veterinarians or breeders, could potentially be at risk for human infections (Karagiannis et al, 2009;Palmela et al, 2012;Sun et al, 2016;Van den Brom et al, 2013). However, the involvement of horses in Q fever epidemiology remains unclear (Marenzoni et al, 2013;Roest et al, 2013). Indeed, the few available serological surveys (Joshi et al, 1978;Lang, 1990;Marenzoni et al, 2013;Raseta and Mihajlovic, 1983) suggest that horses may be naturally exposed to C. burnetii, but these studies are old and performed with serological tests that are less sensitive than ELISA assays (, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…However, the involvement of horses in Q fever epidemiology remains unclear (Marenzoni et al, 2013;Roest et al, 2013). Indeed, the few available serological surveys (Joshi et al, 1978;Lang, 1990;Marenzoni et al, 2013;Raseta and Mihajlovic, 1983) suggest that horses may be naturally exposed to C. burnetii, but these studies are old and performed with serological tests that are less sensitive than ELISA assays (, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seroprevalence of horses to Coxiella burnetii in an Q fever endemic area

Desjardins

Joulié

Pradier

et al. 2018

Veterinary Microbiology

View full text Add to dashboard Cite

Coxiella burnetii can infect many animal species, but its circulation dynamics in and through horses is still unclear. This study evaluated horse exposure in an area known to be endemic for ruminants and humans. We assessed antibody prevalence in horse serum by ELISA, and screened by qPCR horse blood, ticks found on horses and dust from stables. Horse seroprevalence was 4% (n = 335, 37 stables) in 2015 and 12% (n = 294, 39 stables) in 2016. Of 199 horses sampled both years, 13 seroconverted, eight remained seropositive, and one seroreverted. Seropositive horses were located close to reported human cases, yet none displayed Q fever-compatible syndromes. Coxiella DNA was detected in almost 40% of collected ticks (n = 59/148 in 2015; n = 103/305 in 2016), occasionally in dust (n = 3/46 in 2015; n = 1/14 in 2016) but never in horse blood. Further studies should be implemented to evaluate if horses may be relevant indicators of zoonotic risk in urban and suburban endemic areas.

show abstract

Is the horse a reservoir or an indicator of Coxiella burnetii infection? Systematic review and biomolecular investigation

Cited by 23 publications

References 39 publications

Management of Coxiella burnetii infection in livestock populations and the associated zoonotic risk: A consensus statement

Management of Coxiella burnetii infection in livestock populations and the associated zoonotic risk: A consensus statement

Coxiella burnetii, agent de la fièvre Q

Seroprevalence of horses to Coxiella burnetii in an Q fever endemic area

Contact Info

Product

Resources

About