Is the hypercholesterolemic effect of dietary casein related to its phosphorylation state?

Meet, Roelof Van der

doi:10.1016/0021-9150(83)90145-4

Cited by 26 publications

(5 citation statements)

References 15 publications

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“…However, when the Zn content of the casein diet was increased, the expected rise in plasma cholesterol was negated. Thus these results are in agreement with our previous suggestion (Samman & Roberts, 1984) that supplementary Zn, not just Ca (Van der Meer, 1983), may make casein less hypercholesterolaemic. These findings, together with those reported by Van der Meer et al (1985), also strengthen the notion that a protein-mineral interaction is responsible for casein-induced hypercholesterolaemia.…”

Section: S S a M M A N A N D D C K Robertssupporting

confidence: 93%

The importance of the non-protein components of the diet in the plasma cholesterol response of rabbits to casein

Samman

Roberts

1987

Br J Nutr

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I . To characterize further the effect of protein-mineral interaction on plasma cholesterol, four groups of rabbits were placed on cholesterol-free, semi-purified diets for 12 weeks. The diets were similar in proximate composition with either casein or soya-bean protein isolate as the protein source (250 g/kg).2. The dietary zinc content of the casein diets was increased to 22 mg/kg to equal that of the soya-bean diets. The copper content was set at 2 and 6 mg/kg. There were no differences in weight gain; all animals grew at a similar rate.3. When the dietary Zn content was equalized, the plasma and liver cholesterol responses were similar regardless of the source of protein.4. Differences in liver Cu and Zn were observed. As dietary Cu increased, Cu decreased and Zn increased in the liver. Hepatic Zn was also higher in soya-bean-fed than in casein-fed animals.5. No effects on plasma Cu and Zn were seen.6. The addition of Zn to the casein diet resulted in a similar plasma cholesterol to that of animals fed on the soya-bean diet, suggesting that casein-induced hypercholesterolaemia is due to a marginal Zn intake.

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Section: S S a M M A N A N D D C K Robertssupporting

confidence: 93%

The importance of the non-protein components of the diet in the plasma cholesterol response of rabbits to casein

Samman

Roberts

1987

Br J Nutr

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“…Several different explanations have been offered to account for the different effects of dietary proteins on plasma cholesterol levels, e.g., amino acid com position (2, 5-7), digestibility (19)(20)(21)(22)(23) and minor components attached to pro tein (24). However, it appears that conclusive results have not yet been obtained.…”

Section: Discussionmentioning

confidence: 83%

Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.

Sugiyama

Ohkawa

Muramatsu

1986

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…The phosphorylation concept is supported both by in vitro and in vivo experiments. In vitro, casein, when compared to soybean protein or dephosphorylated casein, prevents the binding of glycine-conjugated bile acids to the calcium phosphate sediment (26) . In contrast to glycine-conjugated bile acids, taurine-con jugated bile acids do not bind to the calcium phosphate sediment (27).…”

Section: Fecal Excretion Of Bile Acids and Neutral Steroidsmentioning

confidence: 99%

“…The digestibility theory is not supported by the observation that formaldehyde treatment of casein, which lowers its digestibility , does not lower serum cholesterol concentrations in cholesterol-fed rats (24) and rabbits (25). The second concept to explain inhibition of intestinal steroid absorption in animals fed soybean protein versus casein, relates to the differential phosphorylation state of the two proteins (26). Casein, when compared with soybean protein , is a highly phosphorylated protein as about 40% of the serine residues in casein are esterified with phosphate.…”

Section: Fecal Excretion Of Bile Acids and Neutral Steroidsmentioning

confidence: 99%

Comparison of the Mechanisms Proposed to Explain the Hypocholesterolemic Effect of Soybean Protein versus Casein in Experimental Animals

Beynen¹

1990

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryDiets containing soybean protein generally induce low levels of serum cholesterol in experimental animals, when compared with diets containing casein. The hypocholesterolemia in animals fed soybean protein is associated with increased rates of fecal excretion of bile acids and neutral steroids, low liver cholesterol concentra tions, increased numbers of hepatic apo B/E receptors, increased rates of hepatic cholesterol synthesis, increased rates of bile acid synthesis and decreased rates of lipoprotein cholesterol output by the liver. In this communication the development of the hypocholesterolemia induced by soybean protein is described. The various mechanisms that have been proposed to explain the hypocholester olemic effect of soybean protein are scrutinized, compared and contrasted.

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Is the hypercholesterolemic effect of dietary casein related to its phosphorylation state?

Cited by 26 publications

References 15 publications

The importance of the non-protein components of the diet in the plasma cholesterol response of rabbits to casein

The importance of the non-protein components of the diet in the plasma cholesterol response of rabbits to casein

Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.

Comparison of the Mechanisms Proposed to Explain the Hypocholesterolemic Effect of Soybean Protein versus Casein in Experimental Animals

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