Is the insula linked to sleep? A systematic review and narrative synthesis

Wang, Yangyang; Li, Manli; Li, Wenchao; Xiao, Lifei; Huo, Xianhao; Ding, Jiangwei; Sun, Tao

doi:10.1016/j.heliyon.2022.e11406

Cited by 4 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the results of the correlation analysis between changes in the FC of the right insula with the lateral occipital cortex and right angular gyrus and trait impulsivity further revealed that higher sensation seeking and impulse traits in patients with HUD were related to the FC of the right insula. Researchers have suggested that the insula as a whole is more inclined to induce subjective feeling states in both cognition and motivation than the amygdala, which is responsible for impulse and automatic emotion processing [36,60]. Thus, the insula or its functional connections may be more relevant to emotional temperament, which identifies a stable biological or genetic "core" in an individual's emotional response tendencies toward emotional and cognitive activities in an integrated personality [36].…”

Section: Relationship Between Abnormal Insula Functional Connectivity...mentioning

confidence: 99%

Insula Connectivity Abnormalities Predict Impulsivity in Chronic Heroin Use Disorder: A Cross-Sectional Resting-State fMRI Study

Zhang,

Zhong,

Shao

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

Patients with heroin use disorder (HUD) often exhibit trait impulsivity, which may be an important factor in and a good predictor of addiction. However, the factor structure of HUD trait impulsivity (motor, attentional, and nonplanning) and its neural correlates are not yet known. A total of 24 male volunteers with HUD and 16 healthy control volunteers were recruited for this cross-sectional study. The Barratt Impulsiveness Scale (BIS-11) and resting-state functional magnetic resonance imaging (rs-fMRI) were employed using the insula as a seed point in an effort to understand the association between trait impulsivity and its intrinsic factors and functional connectivity (FC) between the insula and the whole brain. The HUD group in this study exhibited higher total trait impulsivity scores, motor impulsivity, and nonplanning impulsivity than the control group. Changes in FC between the right insula and the lateral occipital cortex and the right angular gyrus were significantly positively correlated with total trait impulsivity scores, motor impulsivity, and nonplanning impulsivity, whereas changes in the FC between the left insula and the left superior frontal gyrus and left frontopolar brain region were significantly negatively correlated with trait impulsivity. Thus, the insula may serve as an important biomarker for identifying trait impulsivity and its intrinsic factor structure in patients with HUDs.

show abstract

Section: Relationship Between Abnormal Insula Functional Connectivity...mentioning

confidence: 99%

Insula Connectivity Abnormalities Predict Impulsivity in Chronic Heroin Use Disorder: A Cross-Sectional Resting-State fMRI Study

Zhang,

Zhong,

Shao

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…Fatal familial insomnia (FFI), a rare autosomal dominant disease, is marked by hypometabolism and neuronal loss in the thalamus and ACC, linking this condition to the SN [ 68 , 69 , 70 , 71 , 72 ]. The role of SN in sleep physiology and pathology is further highlighted by the anesthetics, especially propofol, which lower salience processing, inducing sleep [ 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ]. Moreover, recent studies on sleep-deprived human volunteers and patients with primary insomnia demonstrated altered connectivity in AIC, further linking SN to sleep and wakefulness [ 79 , 80 ].…”

Section: Introductionmentioning

confidence: 99%

Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders?

Sfera,

Thomas,

Ogunjale

et al. 2024

JCM

View full text Add to dashboard Cite

Forensic hospitals throughout the country house individuals with severe mental illness and history of criminal violations. Insomnia affects 67.4% of hospitalized patients with chronic neuropsychiatric disorders, indicating that these conditions may hijack human somnogenic pathways. Conversely, somnolence is a common adverse effect of many antipsychotic drugs, further highlighting a common etiopathogenesis. Since the brain salience network is likely the common denominator for insomnia, neuropsychiatric and neurodegenerative disorders, here, we focus on the pathology of this neuronal assembly and its likely driver, the dysfunctional neuronal and mitochondrial membrane. We also discuss potential treatment strategies ranging from membrane lipid replacement to mitochondrial transplantation. The aims of this review are threefold: 1. Examining the causes of insomnia in forensic detainees with severe mental illness, as well as its role in predisposing them to neurodegenerative disorders. 2. Educating State hospital and prison clinicians on frontotemporal dementia behavioral variant, a condition increasingly diagnosed in older first offenders which is often missed due to the absence of memory impairment. 3. Introducing clinicians to natural compounds that are potentially beneficial for insomnia and severe mental illness.

show abstract

Neural correlates of insomnia with depression and anxiety from a neuroimaging perspective: A systematic review

Peng,

Wang,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

Insomnia affects a substantial proportion of the population and frequently co-occurs with mental illnesses including depression and anxiety. However, the neurobiological correlates of these disorders remain unclear. Here we review magnetic resonance imaging (MRI) studies assessing structural and functional brain associations with depressive and anxiety symptoms in insomnia disorder (ID; n=38), insomnia symptoms in depressive and anxiety disorders (n=14), and these symptoms in the general populations (n=2). The studies on insomnia disorder consistently showed overlapping (salience network: insula and anterior cingulate cortex) and differential MRI correlation patterns between depressive (thalamus, orbitofrontal cortex and its associated functional connectivity) and anxiety (functional connectivity associated with default mode network) symptoms. The insula was also consistently identified as indicating the severity of insomnia symptoms in depressive disorder. In contrast, findings for other regions related to insomnia symptoms in both depressive and anxiety disorders were generally inconsistent across studies, partly due to variations in methods and patient cohorts. In the general population, brain regions in the default mode network provided a functional link between insomnia and depressive symptoms. These findings underscore both the shared and distinct neural correlates among depression, anxiety, and insomnia, providing potential avenues for the clinical management of these conditions.

show abstract

Is the insula linked to sleep? A systematic review and narrative synthesis

Cited by 4 publications

References 50 publications

Insula Connectivity Abnormalities Predict Impulsivity in Chronic Heroin Use Disorder: A Cross-Sectional Resting-State fMRI Study

Insula Connectivity Abnormalities Predict Impulsivity in Chronic Heroin Use Disorder: A Cross-Sectional Resting-State fMRI Study

Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders?

Neural correlates of insomnia with depression and anxiety from a neuroimaging perspective: A systematic review

Contact Info

Product

Resources

About