Adolescent idiopathic scoliosis (AIS) remains a common and potentially severe musculoskeletal disorder. Although its etiology is largely unknown, ongoing research endeavors continue to improve our understanding of its potential origin and its natural history. Advances in understanding its true three-dimensional nature have sought to improve classification and management strategies. This review will attempt to highlight and give an overview of the current concepts in adolescent idiopathic scoliosis. Keywords: AIS, current, natural history, management strategies
EtiologyThe current consensus on adolescent idiopathic scoliosis (AIS) maintains that it has a multifactorial etiology with genetic predisposing factors. Numerous theories continue to span a broad range of plausibilities in the etiopathogenesis of AIS. To date, the literature has focused on genetic links, metabolic and hormonal disturbances, growth asymmetry, central nervous system alterations, and mechanical and connective tissue abnormalities.Multiple reports support the role of inheritance in the development of AIS. Population studies of index patients and their families have reported on an overall risk of inheritance. They suggest an 11% risk to first-degree relatives, 2.4% risk to second-degree relatives, and 1.4% to third-degree relations.1 A meta-analysis of different twin studies found a 73% concordance rate in monozygotic twins compared to 36% in dizygotic twins.2,3