Is the Mediterranean diet a good preventive measure for NASH?

Procopio, Anna Caterina; Paravati, Maria Rosaria; Scarlata, Giuseppe Guido Maria; Parafati, Maddalena; Milić, Natasa; Luzza, Francesco; Abenavoli, Ludovico

doi:10.20517/2394-5079.2023.128

Hepatoma Res

2023

DOI: 10.20517/2394-5079.2023.128

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Is the Mediterranean diet a good preventive measure for NASH?

Anna Caterina Procopio,

Maria Rosaria Paravati,

Giuseppe Guido Maria Scarlata

et al.

Abstract: Non-alcoholic steatohepatitis (NASH) is a clinical condition characterized by inflammation and swelling of the hepatocytes. If not adequately treated, NASH can lead to the development of fibrosis and liver cancer. Currently, drug therapies used in the management of NASH patients are deficient and non-specific. Patients’ adherence to a healthy lifestyle with a low-calorie diet is a crucial element in the treatment of NASH. The Mediterranean diet is a diet that, more than any other, has indicated beneficial effe… Show more

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2024

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Cited by 2 publications

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Impact of diet and gut microbiota changes in the development of hepatocellular carcinoma

Scarlata,

Cicino,

Spagnuolo

et al. 2024

Hepatoma Res

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Hepatocellular carcinoma (HCC) is a primary liver cancer that occurs with a frequency of 85% in patients with liver cirrhosis. It is the sixth most common type of cancer globally. Asia is the continent with the highest incidence (72%), followed by Europe (8%) and Africa (5%). Men are four times more likely than women to develop this cancer, especially in the 70-80 age group. Risk factors include alcoholic liver disease, tobacco use, genetic predisposition, dysmetabolic comorbidities such as type 2 diabetes mellitus and obesity, hepatitis B virus and hepatitis C virus infections, and non-alcoholic fatty liver disease. Unhealthy dietary regimens and gut dysbiosis are additional risk factors that have been recently investigated. These two factors are closely related because the gut microbiota performs several biological functions, including nutrient metabolism, a process that promotes gut homeostasis, known as eubiosis. With regard to the correlation between diet, gut microbiota, and HCC development, there are several mechanisms that have not yet been fully elucidated. This narrative review aims to evaluate the impact of diet and gut microbiota changes in the development of HCC. Our analysis, performed on several clinical and pre-clinical studies, showed that a high-fat diet promotes gut dysbiosis and hepatic fat accumulation, leading to the progression from simple steatosis to HCC, while the Mediterranean diet, rich in fiber and monounsaturated fatty acids, had a protective role. For this reason, international employment of this dietary regimen for therapeutic purposes should be encouraged.

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Impact of diet and gut microbiota changes in the development of hepatocellular carcinoma

Scarlata,

Cicino,

Spagnuolo

et al. 2024

Hepatoma Res

View full text Add to dashboard Cite

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The anticancer activity of quercetin, luteolin, myricetin, and kaempferol in the development of hepatocellular carcinoma: a narrative review

Paravati,

Scarlata,

Milanović

et al. 2024

Hepatoma Res

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Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related deaths worldwide. It presents a significant and rising global health challenge due to its complex development, high mortality rate, and poor prognosis. The primary treatment methods include chemotherapy, radiotherapy, and surgery, yet each is associated with severe side effects. While combination therapies can enhance outcomes, they also tend to amplify the adverse effects. For this reason, the prevention of HCC has a major impact on world health. Current knowledge indicates that a healthy lifestyle combined with a healthy diet is an excellent preventive strategy. In this respect, the Mediterranean diet represents a valid preventive strategy widely recognized by the scientific community. Its effectiveness is proven by the presence of several polyphenols in its main foods, including quercetin, luteolin, myricetin, and kaempferol. These polyphenols are present in different functional foods and show anticancer activity. This narrative review aims to assess the anti-HCC activity of these polyphenols that characterize the Mediterranean diet.

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Is the Mediterranean diet a good preventive measure for NASH?

Cited by 2 publications

References 50 publications

Impact of diet and gut microbiota changes in the development of hepatocellular carcinoma

Impact of diet and gut microbiota changes in the development of hepatocellular carcinoma

The anticancer activity of quercetin, luteolin, myricetin, and kaempferol in the development of hepatocellular carcinoma: a narrative review

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