Is the necrosis/wall ADC ratio useful for the differentiation of benign and malignant breast lesions?

Durur-Subasi, İrmak; Karakaya, Afak Durur; Karaman, Adem; Şeker, Mehmet; Demirci, Elif; Alper, Fatih

doi:10.1259/bjr.20160803

Cited by 19 publications

(12 citation statements)

References 25 publications

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“…Necrosis/wall ADC ratio (NWADCr) is the ratio of the ADC values of the necrosis to the wall. It was shown that NWADCr is statistically different for benign and malignant necrotic breast lesions [1]. Wall of carcinoma and necrosis of an abscess will demonstrate more diffusion restriction because of first one having high cellularity, the large size of nucleus, intracellular macromolecules, the limited size of the extracellular matrix, and the second one showing high viscosity and cellular debris.…”

Section: What Are the Clinical Applications?mentioning

confidence: 99%

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DW-MRI of the breast: a pictorial review

Durur-Subasi

2019

Insights Imaging

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In the current era of breast imaging, magnetic resonance imaging (MRI) has an important role. To get its specificity better, some supporting or cooperative tools might be needed. The search for new methods continues and non-contrast MRI trials are seen. With the shorter and easier acquisition, no need for contrast material, diffusion-weighted (DW)-MRI could be the best collaborator. This pictorial review aims to give an overview of the DW-MRI of the breast by means of a set of specially selected cases.

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Section: What Are the Clinical Applications?mentioning

confidence: 99%

“…Diffusion-weighted magnetic resonance imaging (DW- MRI) is a non-contrast procedure, measuring the motion of water particles in vivo and analyzing microscopic tissue structure: cellularity, membrane integrity, viscosity, fibers, tubules, organelles, and macromolecules [1]. During the acquisition, motion-sensitizing gradients are used.…”

Section: Introductionmentioning

confidence: 99%

DW-MRI of the breast: a pictorial review

Durur-Subasi

2019

Insights Imaging

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“… 13 The necrosis/wall ADC ratio would be more efficient for malignant-benign differentiation in necrotic breast lesions than for measuring only ADC of the wall. 28 Our article presented that the mean inside/wall ADC ratio (1.20 ± 0.28) of the lung cancers was remarkably higher than that (0.74 ± 0.14) of the pulmonary abscesses ( P < .0001). Furthermore, the mean inside ADC value (1.33 ± 0.32 × 10 −3 mm 2 /s) of the lung cancers was remarkably higher than that (0.94 ± 0.42 × 10 −3 mm 2 /s) of the pulmonary abscesses ( P = .0019).…”

Section: Discussionmentioning

confidence: 63%

How to Discriminate Lung Cancer From Benign Pulmonary Nodules and Masses? Usefulness of Diffusion-Weighted Magnetic Resonance Imaging With Apparent Diffusion Coefficient and Inside/Wall Apparent Diffusion Coefficient Ratio

Usuda

Iwai

Yamagata

et al. 2021

Clin Med Insights Oncol

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Background: Although diffusion-weighted imaging (DWI) is useful for differential diagnosis between lung cancers and benign pulmonary nodules and masses (BPNMs), it is difficult to differentiate pulmonary abscesses from lung cancers because pulmonary abscesses show restricted diffusion. With this research we will present how to assess the total apparent diffusion coefficient (ADC) and inside/wall ADC ratio for these pulmonary nodules and masses (PNMs). Methods: The pulmonary lesions were divided into next 3 groups. There were 40 lung cancers, 41 inflammatory benign PNMs (mycobacteria disease 13, pneumonia 12, pulmonary abscess 10, other 6) and 7 noninflammatory benign PNMs. Definitions were as follows: wall ADC = ADC value in outer one-third of the lesion; inside ADC = ADC value in central two-thirds of the lesion: inside/wall ADC ratio = ratio of inside ADC/wall ADC. Results: Mean total ADC (1.26 ± 0.32 × 10−3 mm2/s) of the lung cancers was remarkably lower than that (1.53 ± 0.53) of the BPNMs. The mean total ADC values were 1.26 ± 0.32 in lung cancer, 1.45 ± 0.47 in inflammatory BPNM and 2.04 ± 0.63 in noninflammatory BPNM, and there were significant differences among them. The mean inside ADC value (1.33 ± 0.32) of the lung cancers was remarkably higher than that (0.94 ± 0.42) of the pulmonary abscesses. The mean inside/wall ADC ratio (1.20 ± 0.28) of the lung cancers was remarkably higher than that (0.74 ± 0.14) of the pulmonary abscesses. Conclusions: Although ADC of DWI could differentiate lung cancer from BPNM, the inside/wall ADC ratio of DWI is efficient for differentiation between lung cancer and lung abscess. The inside/wall ADC ratio of DWI strengthens a weak point of DWI.

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“…Currently, breast MRI has been reported to be highly accurate in defining the subgross morphological prognostics (9,14,23,25) such as tumor dimensions and spread as well as lesion characterization (26,27). Also, multifocality and extensive disease are the negative prognostic factors, independent of tumor size (18,28).…”

Section: Discussionmentioning

confidence: 99%

Mass and non-mass breast MRI patterns: a radiologic approach to sick lobe theory

et al. 2020

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Background According to sick lobe theory, one or more lobes of the breast are more prone to the development of carcinoma. However, the implications of this theory in breast magnetic resonance imaging (MRI) are unknown. Purpose To evaluate the MRI appearance of mass type (multifocal and multicentric diseases) and non-mass type (non-mass enhancements) sick lobe patterns, together with the histopathology results. Material and Methods MRI reports of 2015 patients in two tertiary breast imaging centers between June 2012 and June 2018 were retrospectively reviewed for multifocal–multicentric diseases and segmental, linear, and regional enhancements. A total of 113 patients were included. The specimens obtained by thick needle, vacuum, excisional biopsy/lumpectomy or mastectomy after breast MRI scans were pathologically assessed. The pathologic results were categorized as invasive carcinoma, precursor, and benign proliferative lesions according to the 2012 World Health Organization Classification of Tumors. Results The percentage of underlying benign and precursor invasive lesions was significantly different in patients with mass and non-mass MRI patterns. While the pathology results of mass type patterns were premalignant and malignant in all cases, nearly half of the underlying histologies were benign proliferative subtypes in patients with non-mass type patterns. Conclusion In this study, the mass and non-mass patterns derived from sick lobe theory were related to different risks of malignancy in the pathological examinations.

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Is the necrosis/wall ADC ratio useful for the differentiation of benign and malignant breast lesions?

Cited by 19 publications

References 25 publications

DW-MRI of the breast: a pictorial review

DW-MRI of the breast: a pictorial review

How to Discriminate Lung Cancer From Benign Pulmonary Nodules and Masses? Usefulness of Diffusion-Weighted Magnetic Resonance Imaging With Apparent Diffusion Coefficient and Inside/Wall Apparent Diffusion Coefficient Ratio

Mass and non-mass breast MRI patterns: a radiologic approach to sick lobe theory

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