Is the pharmacokinetics of bupivacaine equivalent after lumbar epidural administration through a needle or a catheter in male and female adults?

Faura, A.; Modamio, Pilar; Blanco, D; Segarra, Ignacio; Lastra, Cecilia Fernández; Izquierdo, E.; Casasín, Tomás; Hernández, Eduardo L. Mariño

doi:10.1016/j.biopha.2015.01.003

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Plasma bupivacaine concentrations were determined using HPLC using the methodology described by Purvis et al and Faura et al [11][12][13].…”

Section: Sample Preparation Proceduresmentioning

confidence: 99%

Anti-inflammatory Effect and Plasma Bupivacaine Concentrations After Transversus Abdominis Plane Block for Living Liver Donors: Prospective, Randomized, Blinded Clinical Trial

Yalin,

Erdogan,

Ucar

et al. 2024

Preprint

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Objective Transversus abdominis plane (TAP) blocks were reported to reduce postoperative pain and opioid use. Local anesthetics modulate the local and systemic inflammatory reaction. Our aim was to examine the effect of TAP block with bupivacaine on the anti-inflammatory response in living liver donors (LLDs). Methods The randomized prospective clinical study was carried out 72 LLDs, aged 18–65 scheduled for right hepatectomy. TAP blocks were performed bilaterally with ultrasound guidance using 1.5 mg/kg of 0.5% bupivacaine for Group 2. Group 1 patients were control group. In both groups, blood samples were obtained preoperatively, 30 minutes and 2, 6, and 24 hours following injection for cytokine measurement. In Group 2, to examine the plasma bupivacaine level, blood samples were obtained preoperatively as well as 30 minutes and 1, 2, 6, 12, and 24 hours following injection. The primary outcome was to assess the effect of TAP block on the inflammatory response with cytokine levels. Results No difference was observed between cytokine levels (Tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1) and interleukin 6 (IL-6) between Groups Significant positive correlations were observed between the plasma bupivacaine concentration and IL-1 and IL-6 levels at the 2nd, 6th and 24th hours Conclusions TAP block had no effect on the plasma cytokine concentration. Significant positive correlations were noted between the plasma bupivacaine concentration and IL-1 and IL-6 levels.

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“…Plasma bupivacaine concentrations were determined using HPLC using the methodology described by Purvis et al and Faura et al [11][12][13].…”

Section: Sample Preparation Proceduresmentioning

confidence: 99%

Anti-inflammatory Effect and Plasma Bupivacaine Concentrations After Transversus Abdominis Plane Block for Living Liver Donors: Prospective, Randomized, Blinded Clinical Trial

Yalin,

Erdogan,

Ucar

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Is the pharmacokinetics of bupivacaine equivalent after lumbar epidural administration through a needle or a catheter in male and female adults?

Cited by 1 publication

References 15 publications

Anti-inflammatory Effect and Plasma Bupivacaine Concentrations After Transversus Abdominis Plane Block for Living Liver Donors: Prospective, Randomized, Blinded Clinical Trial

Anti-inflammatory Effect and Plasma Bupivacaine Concentrations After Transversus Abdominis Plane Block for Living Liver Donors: Prospective, Randomized, Blinded Clinical Trial

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