Is the practice of colorectal cancer screening questionable after the NordICC trial was published?

Wong, Martin C. S.; Huang, Junjie; Liang, Peter S.

doi:10.1002/ctm2.1365

Cited by 2 publications

(2 citation statements)

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“…The alterations, which have the ability to be passed down and undone, have a significant impact on the specific control of cellular characteristics 10,11 . As a result, a variety of chromatin modifications, including methylation, acetylation, phosphorylation, ubiquitination, glycosylation and glutarylation, collectively contribute to distinct configurations that impact the efficacy of transcriptional machinery 12–14 . Significantly, the disturbance of epigenetic alterations and metabolic pathways is frequently linked to various illnesses, and the interaction between metabolism and chromatin presents numerous prospects for therapeutic interventions 15,16 …”

Section: Introductionmentioning

confidence: 99%

“…10,11 As a result, a variety of chromatin modifications, including methylation, acetylation, phosphorylation, ubiquitination, glycosylation and glutarylation, collectively contribute to distinct configurations that impact the efficacy of transcriptional machinery. [12][13][14] Significantly, the disturbance of epigenetic alterations and metabolic pathways is frequently linked to various illnesses, and the interaction between metabolism and chromatin presents numerous prospects for therapeutic interventions. 15,16 Recognising the interaction between metabolic remodelling and dynamic histone tuning is of utmost importance as it is currently in its early stages.…”

Section: Introductionmentioning

confidence: 99%

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Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

Zhang,

Song,

et al. 2024

Clinical & Translational Med

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Heightened lactate production in cancer cells has been linked to various cellular mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell dysfunction. The lactate‐induced lactylation of histone lysine residues is noteworthy, as it functions as an epigenetic modification that directly augments gene transcription from chromatin. This epigenetic modification originating from lactate effectively fosters a reliance on transcription, thereby expediting tumour progression and development. Herein, this review explores the correlation between histone lactylation and cancer characteristics, revealing histone lactylation as an innovative epigenetic process that enhances the vulnerability of cells to malignancy. Moreover, it is imperative to acknowledge the paramount importance of acknowledging innovative therapeutic methodologies for proficiently managing cancer by precisely targeting lactate signalling. This comprehensive review illuminates a crucial yet inadequately investigated aspect of histone lactylation, providing valuable insights into its clinical ramifications and prospective therapeutic interventions centred on lactylation.

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Section: Introductionmentioning

confidence: 99%