Is the Prevalence of Metabolic Syndrome and Metabolic Abnormalities Increased in Early Schizophrenia? A Comparative Meta-Analysis of First Episode, Untreated and Treated Patients

Abstract

There is a significantly lower cardiovascular risk in early SZ than in chronic SZ. Both diabetes and pre-diabetes appear uncommon in the early stages, especially in UM. However, smoking does appear to be elevated early after diagnosis. Clinicians should focus on preventing initial cardiometabolic risk because subsequent reduction in this risk is more difficult to achieve, either through behavioral or pharmacologic interventions.

QT dispersion and P wave dispersion in schizophrenia

“…MS which has a role in the aetiology of CVD has been reported at rates of 32-68% in patients who have received antipsychotic treatment and at 3.3-26% in those who have not received any antipsychotic treatment [25]. In treated patients, when the risk of MS is seen to be very high, and in patients who have undergone a first attack of schizophrenia and have not received treatment, there has also been shown to be lower levels of glucose tolerance and higher blood glucose levels compared with healthy control subjects [26]. This shows that schizophrenia, independent of treatment or disease progression, could be related to MS and thereby, CVD [27].…”

The prevalence and mechanisms of metabolic syndrome in schizophrenia: a review

“…The most recent meta-analyses on this topic come from Mitchell and colleagues [Mitchell et al 2011[Mitchell et al , 2012b. The authors provided a very comprehensive review of prevalence and predictors of MetS in adults with schizophrenia and related disorders, accounting for subgroup differences.…”

What are the top 10 physical activity research questions in schizophrenia?

“…Furthermore, antipsychotic medication that is often the mainstay of treatment [14], may improve psychiatric symptoms but in turn, predispose the individual to increased cardiovascular risk and metabolic abnormalities [15,16].…”