Is the Quantification of Interstitial Cells of Cajal in Gastric Biopsy Samples in Patients With Gastroparesis Ready for Prime Time?

Camilleri, Michael; Tack, Jan

doi:10.1053/j.gastro.2023.03.204

Gastroenterology

2023

DOI: 10.1053/j.gastro.2023.03.204

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Is the Quantification of Interstitial Cells of Cajal in Gastric Biopsy Samples in Patients With Gastroparesis Ready for Prime Time?

Michael Camilleri

Jan Tack²

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2023

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Cited by 2 publications

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Optimal measurement of gastric emptying of solids in gastroparesis or functional dyspepsia: evidence to establish standard test

Camilleri,

Zheng,

Vosoughi

et al. 2023

Gut

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ObjectiveSymptoms in gastroparesis (Gp) and functional dyspepsia (FD) overlap; using egg protein substitute to measure gastric emptying of solids (GES), ~40% of patients are reclassified from Gp to FD, and vice versa. Our aim was to assess inter-individual and intra-individual coefficients of variation (COV) in GES in symptomatic patients with Gp or FD with documented slow or normal GES, respectively.DesignScintigraphic GES (T1/2and GE% at 2 and 4 hours) using a 320 kcal real egg meal (30% fat) was tested in the following: single measurements in 20 patients with diabetes mellitus (10 each type 1 and type 2); repeat GES to estimate COVintrameasured: 3 days apart in 9 Gp, 4 weeks apart in 21 Gp and 18 with FD with normal GE assigned to placebo and in 70 patients at 94.3 weeks (median) apart.ResultsCOVinterfor GE% at 4 hours and GE T1/2were respectively 14.2% and 23.5% in FD and 27.5% and 33% in Gp; COVintrafor GE% at 4 hours and GE T1/2up to 4 weeks apart were 23.4% and 37.9% in FD and 20.1% and 33% in Gp. GE% at 2 hours showed less consistent results. However, >85% retained original diagnosis as normal or delayed. From clinical GES to baseline research for Gp group, repeat GES (after treatment) showed the COVintrafor GE% at 4 hours was 37.3% at median 94.3 weeks, with 26/70 changed diagnoses.ConclusionThe 320 kcal (30% fat) GES scintigraphic test provides consistent diagnosis in >85% and should be the standard test for suspected gastric emptying disorders.

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Optimal measurement of gastric emptying of solids in gastroparesis or functional dyspepsia: evidence to establish standard test

Camilleri,

Zheng,

Vosoughi

et al. 2023

Gut

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show abstract

Research Progress of Interstitial Cells of Cajal in Ureteropelvic Junction Obstruction

娜菲莎

2023

ACM

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Is the Quantification of Interstitial Cells of Cajal in Gastric Biopsy Samples in Patients With Gastroparesis Ready for Prime Time?

Cited by 2 publications

References 30 publications

Optimal measurement of gastric emptying of solids in gastroparesis or functional dyspepsia: evidence to establish standard test

Optimal measurement of gastric emptying of solids in gastroparesis or functional dyspepsia: evidence to establish standard test

Research Progress of Interstitial Cells of Cajal in Ureteropelvic Junction Obstruction

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