Is the reflux disease questionnaire useful for identifying GERD according to the Montreal definition?

Abstract

BackgroundScales for aiding physicians diagnose gastro-oesophageal reflux disease (GERD) have not been evaluated in terms of their ability to discriminate between troublesome symptoms (TS) and non-troublesome symptoms (NTS). Our objective is to evaluate the ability of the Reflux Disease Questionnaire (RDQ) to identify GERD according to referral of TS, in patients without previous proton pump inhibitor (PPI) treatment and in patients on PPI treatment.MethodsPatients consulting physicians because of heartburn or acid regurgitation were recruited at 926 primary-care centres in Spain. They were asked to complete several questionnaires including the RDQ, and to define which of their symptoms were troublesome. Information on drug treatment was collected by the physician. We performed a receiver operating characteristic (ROC) curve analysis to ascertain the RDQ's optimum cut-point for identifying TS.Results4574 patients were included, 1887 without PPI and 2596 on PPI treatment. Among those without PPI treatment, 1722 reported TS. The area under the curve (AUC) was 0.79 for the RDQ, and the optimum RDQ cut-point for identifying TS was 3.18 (sensitivity, 63.2%; specificity, 80.2%). A total of 2367 patients on PPI treatment reported TS, and the optimum RDQ cut-off value was 3.06 (sensitivity, 65.4%; specificity, 71.8%).ConclusionsAn RDQ score higher than 3 shows good sensitivity and specificity for differentiating TS from NTS among patients without PPI or on PPI treatment. The RDQ is useful in primary care for diagnosis of GERD based on the Montreal definition.

24‐hour pH‐impedance monitoring on therapy to select patients with refractory reflux symptoms for antireflux surgery. A single center retrospective study

“…calculated thresholds differentiating troublesome from non‐troublesome GER symptoms based on the Montreal definition. A RDQ above 3.18 and 3.06 were considered as significantly associated with troublesome symptoms in patients off and on PPI, respectively …”

Comparison of Endoscopic Findings with Gastroesophageal Reflux Disease Questionnaires (GerdQ) and Reflux Disease Questionnaire (RDQ) for Gastroesophageal Reflux Disease in Medan

“…9 The RDQ is useful in primary care for screening and diagnosis of GERD. 10,11,12 In this study, we try to compare GerdQ diagnosing GERD and its relationship with endoscopic This study was a cross sectional analytical study related symptoms with or without heartburn and/or regurgitation that were admitted to endoscopy units at Adam Malik General Hospital and Permata Bunda Hospital, Medan, Indonesia from October-December 2015. Inclusion criteria are stated as followings: dyspepsia related symptoms with or without heartburn or regurgitations, willing to be recruited in the study, and signed the informed consent.…”

Continuous positive airway pressure for obstructive sleep apnoea does not improve asthma control

“…Patients with asthma have an increased risk of new onset of OSA, suggesting that the alteration in pharyngeal airway patency, systemic inflammation, asthma medications or sleep fragmentation due to asthma may play a role in the development of OSAS although the underlying mechanistic links remain to be tested . Moreover, co‐morbid GER disease related to transient lower oesophageal sphincter relaxation causing pharyngeal spasm and mucosal inflammation may contribute to pathogenesis although our patients did not have significant GER symptoms, reflected by the RDQ score lower than 3 as the cut‐off point . Although rhinitis and nasal obstruction contribute to sleep‐disordered breathing, there was no significant difference in the SFAR score between OSAS and non‐OSAS patients.…”