Is the Relationship between Depression and C Reactive Protein Level Moderated by Social Support in Elderly?-Korean Social Life, Health, and Aging Project (KSHAP)

Abstract

ObjectiveTo investigate the buffering effects of social support as an effects modifier in the association between depression and inflammation in the elderly.MethodsWe analyzed the Korean Social Life, Health, and Aging Project (KSHAP) for questionnaire, clinical, and laboratory data of 530 older adults living in a rural community. Multivariate regression models were used to investigate the association between depressive symptoms and C-reactive protein level (CRP), a marker of inflammation, at varying levels of social support.ResultsSocial support affected the association between depressive symptoms and CRP level in both sexes. However, the direction of effects modification was different for men and women. In men, a higher CRP level was significantly associated with depressive symptoms only among those with lower support from a spouse or family members. By contrast, in women, the association was significant only among subgroups with higher spousal or family support. Social support from neighbors or friends did not affect the depression-inflammation relationship in men but modestly affected the relationship in women.ConclusionOur findings suggest that social support may have a buffering effect in the relationship between depression and inflammation in elderly Koreans. But the influence of social support may run in different directions for men and women.

Racial and ethnic differences in the associations between social integration, C-reactive protein and depressive symptoms

“…Despite established dyadic links between social integration, inflammation, and depression, the association between all three remains ambiguous. Hur et al (2018) find that social support buffers the relationship between CRP and depressive symptoms among men, but not women. Among female cancer patients, baseline feelings of social support are associated with fewer depressive symptoms and lower levels of inflammation at the end of the study ( Hughes et al, 2014 ).…”

“…Some studies test associations between social ties, inflammation, and depressive symptoms, but among these, the only study to even control for race/ethnicity is among adolescents ( Guan et al, 2016 ). Other studies do not consider variations by race/ethnicity likely due to lack of sample variation ( Hur et al, 2018 ) or sample size ( Eisenberger et al, 2010 ). Additionally, this emerging area of research focuses on social support rather than social integration, and results may change with a different metric of social ties.…”

Geschlechtsunterschiede in Glucocorticoidkonzentrationen und Entzündungsparametern im Zusammenhang mit Depression

“…Tab. 3 zeigt die Studienergebnisse in Bezug auf die basalen Konzen trationenderEntzündungsmarkerCRP,IL-6undTNF-α.Diedeutli che Mehrheit der Studien, welche den Zusammenhang von Depres sivität und CRPSpiegeln untersuchten, kam zu dem Ergebnis, dass die CRPSpiegel bei Frauen oft unabhängig von deren Depressivität waren, während eine schwere Depressionssymptomatik bei Män nern mit erhöhten CRPSpiegeln assoziiert ist [52][53][54][55][56][57][58][59][60], vor allem in VerbindungmitsozialerIsolation [61].Amzweithäufigstenwurde repliziert, dass CRP nur bei Frauen positiv mit Depression korre liert [62][63][64][65]. Darüber hinaus existieren vereinzelte andere Befun de [66][67][68].Sehrhäufigkonntedarüberhinausrepliziertwerden, dass die mittleren CRPSpiegel bei Frauen generell höher ausfal len als bei Männern [52-54, 58, 66], auch unter Probanden mit er höhter Depressionssymptomatik [62].…”

Depressive State Detection Model in Arabic User-Generated

“…According to the World Health Organization (WHO), 350 million people are affected by depression (Marcus et al,2012). It causes bodily problems, fatigue, uncertainty, loss of interest, and disruption of mood (Hur et al,2018). The fundamental issue with mental illness is that it is neither treated nor given a proper diagnosis.…”