Is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present intraperitoneally in patients with coronavirus disease 2019 (COVID-19) infection undergoing emergency operations?

Seeliger, Barbara; Philouze, Guillaume; Benotmane, Ilies; Mutter, Didier; Pessaux, Patrick

doi:10.1016/j.surg.2020.05.033

Cited by 29 publications

(35 citation statements)

References 5 publications

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“…On the other hand, while reports on patients with cirrhosis and SARS-CoV-2 show a high rate of decompensation with ascites [10], viral etiology in this clinical scenario has not been very well described thus far. At the same time, viral RNA was not detected in samples of ascitic fluid from surgical patients according to previous studies [11,12], so it remains a matter demanding further investigation, especially because these reports present a small number of patients requiring emergency operations and no information regarding comorbidities or immune status.…”

Section: Discussionmentioning

confidence: 88%

“…At the same time, viral RNA was not detected in samples of ascitic fluid from surgical patients according to previous studies [ 11 , 12 ], so it remains a matter demanding further investigation, especially because these reports present a small number of patients requiring emergency operations and no information regarding comorbidities or immune status.…”

Section: Discussionmentioning

confidence: 95%

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Detected SARS-CoV-2 in Ascitic Fluid Followed by Cryptococcemia: a Case Report

Passarelli

Perosa

Luna

et al. 2020

SN Compr. Clin. Med.

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SARS coronavirus-2 (SARS-CoV-2) detection in different clinical specimens has raised important insights about its pathogenesis, but some details remain to be understood. In that respect, disrupt viral control seen in solid organ transplant patients on chronic immunosuppression can help unveil pathogenic mechanisms and characterize new coronavirus disease-19 (COVID-19) immunological and clinical aspects, as well as secondary complications. We herein report a case of SARS-CoV-2 detection in ascitic fluid from a kidney transplant patient with decompensated cirrhosis and COVID-19 and then discuss about immune, cellular, and virological aspects of such clinical presentation of the disease, which also included a disseminated infection, demonstrated by viral detection in his blood sample. We subsequently discuss about the fatal outcome caused by a secondary bloodstream infection by Cryptococcus neoformans. This unprecedented case report presents ascitic fluid as a novel specimen in which SARS-CoV-2 can be detected. Immune dysregulation and cumulative risk factors may lead to secondary infections by opportunistic agents, including Cryptococcus neoformans.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 95%

Detected SARS-CoV-2 in Ascitic Fluid Followed by Cryptococcemia: a Case Report

Passarelli

Perosa

Luna

et al. 2020

SN Compr. Clin. Med.

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“…ACE2 is expressed in the gastrointestinal tract and could be injured directly via entry into enterocytes or indirectly via the host in ammatory response (16,33), but not all publications have demonstrated the virus presence in PF. In our CAPD patient, bacterial peritonitis was present when the sample was taken, while in the AKI patient, the severity of the infection and kidney and heart stress were evident.…”

Section: Resultsmentioning

confidence: 99%

“…Some reports have identi ed the presence of genetic material in the PF, and it was associated with PD failure (12,13). However, other reports have not detected the presence of the virus in the PF (14)(15)(16)(17).…”

Section: Read Full Licensementioning

confidence: 99%

Detection of SARS-CoV-2 in peritoneal fluid from patients with kidney disease and COVID-19: report of two cases

Ibarra-Hernandez

Alcantar-Vallín

Cabrera-Silva

et al. 2020

Preprint

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Background: Coronavirus disease-2019 (COVID-19) has a broad clinical presentation, involving multiple organs besides the respiratory system. Currently, there is little evidence available on the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in peritoneal fluid (PF). In this study, we describe the detection of SARS-CoV-2 in the PF of two patients with COVID 19 and kidney disease.Case presentation: Case 1: A 71-year-old woman with a history of end-stage kidney disease who presented with a 15-day evolution of progressive dyspnea, accompanied by dry cough and fever; IgM antibodies to SARS-CoV-2 were detected on admission. Real-time SARS-CoV-2 polymerase chain reaction (qRT-PCR) in the PF was positive. Three days after admission the patient's respiratory distress improved and she was discharged after 8 days of hospitalization.Case 2: A 78-year-old woman, with type 2 diabetes, hypertension, a 15-day history of polypnea, and a 5-day onset of fever and dyspnea. IgM and IgG antibodies to SARS-CoV-2 were detected on admission, as well as a positive nasopharyngeal qRT-PCR test for SARS-CoV-2. During hospitalization she developed acute kidney injury, requiring peritoneal dialysis, SARS-CoV-2 was confirmed in PF by qRT-PCRConclusions: These two cases highlights the importance of increasing the level of awareness for the presence and possible SARS-CoV-2 transmission through non-respiratory routes, like peritoneal fluid.Emphasis should be given to appropriate preventive strategies for minimizing the risk of transmission of COVID-19 from patients on peritoneal dialysis in both inpatient and outpatient settings.

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“…In our study 1 , peritoneal fluid was sampled in syringes at the procedural beginning and/or end and analyzed in the virology laboratory on site. We expected to enable…”

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confidence: 99%

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in peritoneal fluid of coronavirus disease 2019 (COVID-19) patients—Prevalence and significance

Seeliger¹,

Pessaux²

2021

Surgery

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present intraperitoneally in patients with coronavirus disease 2019 (COVID-19) infection undergoing emergency operations?

Abstract: contributed equally to this study. All authors participated in the study conception and design, data collection, analysis and interpretation, manuscript drafting and revision. All authors critically reviewed and approved the final report.

Cited by 29 publications

References 5 publications

Detected SARS-CoV-2 in Ascitic Fluid Followed by Cryptococcemia: a Case Report

Detected SARS-CoV-2 in Ascitic Fluid Followed by Cryptococcemia: a Case Report

Detection of SARS-CoV-2 in peritoneal fluid from patients with kidney disease and COVID-19: report of two cases

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in peritoneal fluid of coronavirus disease 2019 (COVID-19) patients—Prevalence and significance

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