We analysed data from 155 revisions of identical cementless hip prostheses to determine the influence of patient-, implant-and surgery-related factors on the polyethylene wear rate and size of periprosthetic osteolysis (OL). This was calculated by logistic regression analysis. Factors associated with an increased/decreased wear rate included position of the cup relative to Kohler's line, increase in abduction angle of the cup, traumatic and inflammatory arthritis as a primary diagnosis, and patient height. Severe acetabular bone defects were predicted by an increased wear rate (odds ratio, OR=5.782 for wear rate above 200 mm 3 /y), and increased height of the patient (OR= 0.905 per each centimetre). Predictors of severe bone defects in the femur were the increased wear rate (OR=3.479 for wear rate above 200 mm 3 /y) and placement of the cup outside of the true acetabulum (OR=3.292). Variables related to surgical technique were the most predictive of polyethylene wear rate.