Is the world crippled by antimicrobial resistance, or simply lacking information?

Al Meslamani, Ahmad Z.

doi:10.1080/14787210.2024.2322429

Expert Review of Anti-infective Therapy

2024

DOI: 10.1080/14787210.2024.2322429

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Is the world crippled by antimicrobial resistance, or simply lacking information?

Ahmad Z. Al Meslamani

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2024

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Cited by 2 publications

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A Greener Process for the Synthesis of Base‐Catalyzed Substituted Pyrazoles and Triazolopyrimidines as Prospective Biological Activity

Bawazir,

Al‐amshany,

El‐shishtawy

et al. 2024

ChemistrySelect

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Novel 1H‐pyrazole analogues were generated in high yields via the cyclocondensation of chalcone derivatives with p‐toluene sulfonyl hydrazine, utilizing K2CO3 and iodine as catalysts under heat for 2 h. A straightforward and effective manner was carried out for the creation of substituted pyrazoles or triazolopyrimidines via tandem methods containing aryl sulfonyl/benzoyl chloride and 1H‐pyrazole derivatives, or chalcones and 5‐aminotriazole, with catalytic amounts of K2CO3 or KOH, respectively. By researching with different solvents and catalysts, the reaction conditions for this technique were improved, resulting in good to excellent yields of the intended products 4aa‐cb and 6A‐d. This method is observed for its enhanced yields and environmental friendliness. The structures of the novel molecules have been verified by spectroscopic and elemental analysis techniques. The novel targets were validated versus various pathogenic and fungal strains. Contrasting the new series of products to reference drugs, pyrazole derivative 2b were the strongest antimicrobial actions, with MIC values varying from 0.98–19.45 µM.

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A Greener Process for the Synthesis of Base‐Catalyzed Substituted Pyrazoles and Triazolopyrimidines as Prospective Biological Activity

Bawazir,

Al‐amshany,

El‐shishtawy

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

Mechanism of antibacterial phytoconstituents: an updated review

Abass,

Parveen,

Irfan

et al. 2024

Arch Microbiol

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Is the world crippled by antimicrobial resistance, or simply lacking information?

Cited by 2 publications

References 22 publications

A Greener Process for the Synthesis of Base‐Catalyzed Substituted Pyrazoles and Triazolopyrimidines as Prospective Biological Activity

A Greener Process for the Synthesis of Base‐Catalyzed Substituted Pyrazoles and Triazolopyrimidines as Prospective Biological Activity

Mechanism of antibacterial phytoconstituents: an updated review

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