Is therapeutic hypothermia during neonatal extracorporeal membrane oxygenation associated with intracranial hemorrhage?

Cashen, Katherine; Reeder, Ron; Shanti, Christina; Dalton, Heidi J.; Dean, Jonathan; Meert, Kathleen L.

doi:10.1177/0267659117747693

Cited by 19 publications

(9 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results indicate a possibility of decreased risk of intracranial hemorrhage and improved survival to discharge with VV ECMO compared to VA ECMO. Some studies in pediatric ECMO population have demonstrated increased risk of mortality and intracranial hemorrhage with VA ECMO compared to VV ECMO [14][15][16]. The loss of pulsatile arterial flow during VA ECMO could disturb cerebral autoregulation and contribute to increased risk of intracranial hemorrhage [17].…”

Section: Discussionmentioning

confidence: 99%

In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation

et al. 2019

Self Cite

View full text Add to dashboard Cite

Objective To determine in-hospital outcomes of neonates with hypoxic ischemic encephalopathy (HIE) requiring extracorporeal membrane oxygenation (ECMO). Study design Single-center retrospective study from 2005 to 2016 of neonates ≥35 weeks gestation with moderate/severe HIE, requiring ECMO for persistent pulmonary hypertension of newborn (PPHN). Results Our cohort (n = 20) received therapeutic hypothermia for moderate (n = 12), severe (n = 5), or undocumented severity (n = 3) of HIE. During ECMO, 30% (n = 6) infants developed intracranial hemorrhage at a median (IQR) duration of 24 (20) hours. Sixteen (80%) infants survived to discharge, among which 15 had MRI performed; 47% (n = 7) had normal MRI, 20% (n = 3) had intracranial hemorrhage and 13% (n = 2), 13% (n = 2) and 7% (n = 1) had NICHD stage 1, 2, and 3 pattern of brain injury respectively. Conclusions In this high-risk population of neonates, use of ECMO was safe and efficacious as demonstrated by survival and outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…ECMO flow rate and core body temperature were collected daily at 7 AM. Because the use of therapeutic hypothermia was not recorded in the BATE study, therapeutic hypothermia was defined as a core body temperature ≤34°C for two consecutive days during the first three days of ECMO (17). Transfusion volumes included daily volumes of red blood cells, platelets and fresh frozen plasma administered.…”

Section: Methodsmentioning

confidence: 99%

Hemolysis During Pediatric Extracorporeal Membrane Oxygenation: Associations With Circuitry, Complications, and Mortality

Dalton

Cashen

Reeder

et al. 2018

Pediatric Critical Care Medicine

Self Cite

View full text Add to dashboard Cite

Hemolysis is common during pediatric extracorporeal membrane oxygenation. Hemolysis may contribute to the development of renal failure, and therapies used to manage renal failure such as in-line hemofiltration and other forms of continuous renal replacement therapy may contribute to hemolysis. Hemolysis was not associated with mortality after controlling for other factors. Monitoring for hemolysis should be a routine part of extracorporeal membrane oxygenation practice, and efforts to reduce hemolysis may improve patient care.

show abstract

“…This was a retrospective, observational study that included validated data from ELSO registry and did not have neurodevelopmental follow-up data to access long-term efficacy and safety of TH with ECMO (17). On the other hand, a recent study by Cashen et al showed that TH during neonatal ECMO is associated with intracranial hemorrhage, and they suggested to evaluate the patient with considering the potential risks before applying TH with ECMO (20).…”

Section: Discussionmentioning

confidence: 99%

A Successful Whole Body Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy During an ECMO Run in a Newborn

et al. 2019

View full text Add to dashboard Cite

Data regarding the safety of using therapeutic hypothermia (TH) with extracorporeal membrane oxygenation (ECMO) in neonates with both hypoxic ischemic encephalopathy (HIE), and respiratory failure are lacking. TH is not associated with an increased incidence of hemostatic complications, but hypothermia may impair coagulation. Herein, we report a case of a newborn who had meconium aspiration syndrome and HIE and underwent both TH and ECMO. He did not have any bleeding or circuit complications, and mortality as short-term outcome along with well-neurodevelopmental outcome.

show abstract

Is therapeutic hypothermia during neonatal extracorporeal membrane oxygenation associated with intracranial hemorrhage?

Abstract: Therapeutic hypothermia during neonatal ECMO appears to be associated with intracranial hemorrhage.

Cited by 19 publications

References 41 publications

In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation

In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation

Hemolysis During Pediatric Extracorporeal Membrane Oxygenation: Associations With Circuitry, Complications, and Mortality

A Successful Whole Body Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy During an ECMO Run in a Newborn

Contact Info

Product

Resources

About