Is There a Difference in Serum Vitamin D Levels and Bone Mineral Density According to Body Mass Index in Young Adult Women?

Lim, Hee‐Sook; Byun, Dong Won; Suh, Kyoil; Park, Hyeong Kyu; Kim, Hye Jeong; Kim, Tae-Hee; Lee, Hae‐Hyeog

doi:10.11005/jbm.2019.26.3.145

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…Recombinant human (Rh) leptin in the treatment of BMSCs significantly facilitated bone formation. In addition, leptin downregulated CYP24A1 and up-regulated CYP27B1, CYP27A1, and VDR, all of which play key roles in vitamin D metabolism In summary, this study confirmed the relationship between obesity, vitamin D metabolism and osteoblastic development, and the direct effect of leptin on vitamin D metabolism and osteoblastic differentiation of BMSCs may protect bone under the effect of low serum 25(OH)D in obese people (Lim et al, 2019;Li J. et al, 2020).…”

Section: Obesity and Bone-related Diseases Osteoporosissupporting

confidence: 72%

Obesity and Bone Health: A Complex Link

Hou

et al. 2020

Front. Cell Dev. Biol.

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So far, the connections between obesity and skeleton have been extensively explored, but the results are inconsistent. Obesity is thought to affect bone health through a variety of mechanisms, including body weight, fat volume, bone formation/resorption, proinflammatory cytokines together with bone marrow microenvironment. In this review, we will mainly describe the effects of adipokines secreted by white adipose tissue on bone cells, as well as the interaction between brown adipose tissue, bone marrow adipose tissue, and bone metabolism. Meanwhile, this review also reviews the evidence for the effects of adipose tissue and its distribution on bone mass and bone-related diseases, along with the correlation between different populations with obesity and bone health. And we describe changes in bone metabolism in patients with anorexia nervosa or type 2 diabetes. In summary, all of these findings show that the response of skeleton to obesity is complex and depends on diversified factors, such as mechanical loading, obesity type, the location of adipose tissue, gender, age, bone sites, and secreted cytokines, and that these factors may exert a primary function in bone health.

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Section: Obesity and Bone-related Diseases Osteoporosissupporting

confidence: 72%

Obesity and Bone Health: A Complex Link

Hou

et al. 2020

Front. Cell Dev. Biol.

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“…Sergeev considered that intake of vitamin D could induce the reduction of fat tissue by inhibition of Ca 2+ ‐mediated apoptosis in adipocytes 20 . In addition, Lim et al found that obese women had lower levels of serum vitamin D and lumbar‐2 T ‐score than normal weight women 21 . All of the above provide a possible explanation for our findings of an inverse association between serum vitamin D level and bone marrow fat value.…”

Section: Discussionmentioning

confidence: 53%

“…20 In addition, Lim et al found that obese women had lower levels of serum vitamin D and lumbar-2 T-score than normal weight women. 21 All of the above provide a possible explanation for our findings of an inverse association between serum vitamin D level and bone marrow fat value.…”

Section: The Relationship Of Metabolic Syndrome and Bone Marrow Fatmentioning

confidence: 68%

Bone Marrow Fat Measured by a Chemical Shift‐Encoded Sequence (IDEAL‐IQ) in Patients With and Without Metabolic Syndrome

Cheng

Hou

et al. 2021

Magnetic Resonance Imaging

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Background: Metabolic syndrome increases the risk of chronic diseases such as cardiovascular disease and diabetes. Metabolic syndrome also has an impact on bone mineral density. However, the relationship between metabolic syndrome and bone marrow fat is unclear. Purpose: To determine factors associated with bone marrow fat concentration in subjects with and without metabolic syndrome. Study Type: Retrospective. Population: One hundred and one women with metabolic syndrome (31.0 years AE5.1) and 96 female living liver transplant donors (32.0 years AE3.7). Our institutional review board approved the study. Each subject signed written informed consent. Field Strength/Sequence: 3.0 T MRI system and a commercially available chemical shift-encoded 3D sequence (Iterative Decomposition of water and fat with Echo asymmetry and Least Square Estimation). Assessment: Proton density fat fraction (PDFF) in liver, vertebral body, and paraspinal muscle (erector spinae) were measured from a single acquisition by a 15-year-experience orthopedic radiologist. The factors associated with PDFF were acquired. Statistical Tests: The analysis of covariance test, after adjustment for body mass index and age, was used to analyze the differences between metabolic syndrome and non-metabolic syndrome groups. A stepwise multiple regression analysis was used to determine which variables were independently associated with PDFF. Results: Mean vertebral PDFF and alanine aminotransferase (ALT) were significantly lower in donors than subjects with metabolic syndrome (both P < 0.05). Serum vitamin D concentration, ferritin, and high-density lipoprotein (HDL) cholesterol were significantly higher in donors than subjects with metabolic syndrome (all P < 0.05). Multiple regression analysis revealed antidiabetic medicine, higher serum vitamin D concentration, lower waist circumference, lower ferritin, lower HDL, absence of metabolic syndrome, and lower ALT were significantly associated with lower vertebral PDFF (all P < 0.05). Data Conclusion: Multiple factors affect bone marrow fat concentration in subjects with metabolic syndrome. Serum vitamin D concentration and antidiabetic medicine are associated with low bone marrow fat, whereas waist circumference, serum ferritin, metabolic syndrome, imbalanced lipid metabolism, and abnormal liver function are associated with high bone marrow fat.

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“…Lumbar spine aBMD by DXA . Lumbar spine aBMD measured by DXA was reported in 56 studies [ 20 – 22 , 52 , 54 , 56 , 59 – 61 , 67 – 72 , 78 , 81 , 84 , 85 , 87 – 89 , 92 – 94 , 97 , 100 , 103 , 106 – 108 , 110 , 112 – 115 , 118 , 120 , 121 , 124 , 126 , 128 , 130 – 132 , 134 , 135 , 142 – 144 , 148 , 150 – 153 , 163 , 167 , 173 , 177 – 181 ], including 29,420 participants. Obesity was associated with increased lumbar spine aBMD in postmenopausal women (n = 27: MD = 0.07 g/cm 2 , 95% CI: 0.05, 0.09, P<0.00001, I 2 = 92%), premenopausal women (n = 17: MD = 0.07 g/cm 2 , 95% CI: 0.04, 0.09, P<0.0001, I 2 = 90%), men (n = 8: MD = 0.06 g/cm 2 , 95% CI: 0.04, 0.08, P<0.00001, I 2 = 48%), and in studies combining men and women (n = 12: MD = 0.06 g/cm 2 , 95% CI: 0.03, 0.08, P<0.00001, I 2 = 93%) ( ...…”

Section: Resultsmentioning

confidence: 99%

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

et al. 2021

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Background The association between obesity and fracture risk may be skeletal site- and sex-specific but results among studies are inconsistent. Whilst several studies reported higher bone mineral density (BMD) in patients with obesity, altered bone quality could be a major determinant of bone fragility in this population. Objectives This systematic review and meta-analysis aimed to compare, in men, premenopausal women and postmenopausal women with obesity vs. individuals without obesity: 1) the incidence of fractures overall and by site; 2) BMD; and 3) bone quality parameters (circulating bone turnover markers and bone microarchitecture and strength by advanced imaging techniques). Data sources PubMed (MEDLINE), EMBASE, Cochrane Library and Web of Science were searched from inception of databases until the 13th of January 2021. Data synthesis Each outcome was stratified by sex and menopausal status in women. The meta-analysis was performed using a random-effect model with inverse-variance method. The risks of hip and wrist fracture were reduced by 25% (n = 8: RR = 0.75, 95% CI: 0.62, 0.91, P = 0.003, I2 = 95%) and 15% (n = 2 studies: RR = 0.85, 95% CI: 0.81, 0.88), respectively, while ankle fracture risk was increased by 60% (n = 2 studies: RR = 1.60, 95% CI: 1.52, 1.68) in postmenopausal women with obesity compared with those without obesity. In men with obesity, hip fracture risk was decreased by 41% (n = 5 studies: RR = 0.59, 95% CI: 0.44, 0.79). Obesity was associated with increased BMD, better bone microarchitecture and strength, and generally lower or unchanged circulating bone resorption, formation and osteocyte markers. However, heterogeneity among studies was high for most outcomes, and overall quality of evidence was very low to low for all outcomes. Conclusions This meta-analysis highlights areas for future research including the need for site-specific fracture studies, especially in men and premenopausal women, and studies comparing bone microarchitecture between individuals with and without obesity. Systematic review registration number CRD42020159189

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Is There a Difference in Serum Vitamin D Levels and Bone Mineral Density According to Body Mass Index in Young Adult Women?

Cited by 6 publications

References 26 publications

Obesity and Bone Health: A Complex Link

Obesity and Bone Health: A Complex Link

Bone Marrow Fat Measured by a Chemical Shift‐Encoded Sequence (IDEAL‐IQ) in Patients With and Without Metabolic Syndrome

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

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