Is There a Link between Dendrocytes, Fibrosis and Sclerosis?

Piérard, G. E.; Arrese-Estrada, Jorge; Piérard-Franchimont, C; Deleixhe-Mauhin, F.

doi:10.1159/000247819

Cited by 35 publications

(25 citation statements)

References 7 publications

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“…9,11,23 The reduction of CD34 + and factor XIIIa + cells occurred early in the evolution of the disease and could be noted in patients with 1 year or less of disease duration. CD34 + cells are localized mainly in reticular and periadnexal dermis, and factor XIIIa + cells are localized mainly in papillary dermis.…”

Section: Discussionmentioning

confidence: 99%

Dermal Dendritic Cell Population and Blood Vessels Are Diminished in the Skin of Systemic Sclerosis Patients

de-Sá-Earp¹,

Nascimento²,

Carneiro³

et al. 2013

The American Journal of Dermatopathology

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Recent studies have suggested that the number of dermal dendritic cells is altered in the skin of patients with scleroderma and that these cells may have an important role in the pathogenesis of this disease. There is also a belief that insufficient blood flow to the affected organs may also be responsible for the disease. Our aim was to quantify CD34+ cells, factor XIIIa cells, and blood vessels in the skin of patients with systemic sclerosis and to correlate these data with fibrosis degree and duration of disease. Paraffin-embedded skin sections from patients with systemic sclerosis and from healthy subjects were immunolabelled with antibodies against CD34+ and factor XIIIa. Cells and blood vessels were quantified in the papillary and reticular dermis. Both, the number of CD34+ cells and factor XIIIa cells in the skin of patients with systemic sclerosis were reduced. The reduction of these cell types preceded the appearance of intense fibrosis, suggesting that fibrosis is not responsible of this phenomenon. Blood vessel volume and surface density were also reduced in the skin of systemic sclerosis patients. This reduction was also noted early in the evolution of the disease. Our results suggest that CD34+ cells and factor XIIIa cells may contribute to normal regulation of extracellular matrix assembly. We confirmed the observation that capillary density is diminished in scleroderma skin.

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Section: Discussionmentioning

confidence: 99%

Dermal Dendritic Cell Population and Blood Vessels Are Diminished in the Skin of Systemic Sclerosis Patients

de-Sá-Earp¹,

Nascimento²,

Carneiro³

et al. 2013

The American Journal of Dermatopathology

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“…The characteristics of factor XIIIa-positive cells have been studied most extensively in human skin, in which there is a population of dermal dendritic cells that bind antibodies against factor XIIIa [6,15,36,37,62,63]. They have been shown to display phagocytic functions [5,16], to act as antigen-presenting cells [15,37] and to be involved in regulatory mechanisms of deposition of extracellular macromolecules in the dermis [61]. The presence of factor XIIIa-positive dendrocytes has also been reported in close apposition to skin carcinoma and malignant melanoma [5,6,29].…”

Section: Introductionmentioning

confidence: 99%

Inverse modulation of intraepithelial Langerhans' cells and stromal macrophage/dendrocyte populations in human papillomavirus-associated squamous intraepithelial lesions of the cervix

Al-Saleh

Delvenne

Arrese

et al. 1995

Vichows Archiv A Pathol Anat

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Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal macrophages/dendrocytes by immunohistochemistry using anti-S100, -L1, -CD68 and -factor XIIIa antibodies. Human papillomavirus (HPV) detection was performed in all cases by using first a mixture of DNA probes for 14 HPV types commonly found in anogenital biopsies at low stringency conditions (Tm -40 degrees C) and by reanalyzing the tissues at high stringency (Tm -10 degrees C) with HPV 6/11, 16/18 and 31/33/35 biotinylated probe cocktails and individual digoxigenin-labelled probes. SILs and metaplastic tissues were significantly associated with a depletion of S100-positive intraepithelial Langerhans' cells when compared with normal epithelium. In contrast, there was a significant increase in L1-positive stromal macrophages in SIL biopsies compared with normal or metaplastic cervix. A significantly higher density of CD68-positive macrophages was also observed in high-grade SILs compared with normal or metaplastic biopsies and with low-grade SILs. The density of factor XIIIa-positive dendrocytes was found to be higher in SILs compared with metaplastic tissues and in high-grade SILs when compared with normal cervical biopsies. No specific relationship was found between the densities of these cells and the HPV type detected in SILs separated into low grade and high grade. The significance of this inverse modulation of intraepithelial Langerhans' cells and stromal macrophages/dendrocytes in normal and SIL biopsies is discussed in relation to HPV infection and malignant transformation.

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“…Most likely, the variability in Factor XIIIa expression in dermato-fibroma is the result of the age of the lesion. Similarly, this appears to be true in morphoea (78,79). Variability of expression suggests that the Factor XIIIa expression in dermal cells is a facultative function induced by undefined factors that are released locally (80).…”

Section: Factor Xiiia + Dendrocytes In Fibroplasiamentioning

confidence: 79%

“…Factor XIIIa + DD may be almost absent in sclerotic areas associated with benign and malignant neoplasms (70,78,88). The connective tissue built up in epulis show changes at different stages and Factor XIII is detected in monocytederived tissue macrophages, which are widely and homogeneously distributed in granulation tissue.…”

Section: Factor Xiiia + Dendrocytes In Fibroplasiamentioning

confidence: 99%

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Molecular mapping of Factor XIIIa-enriched dendrocytes in the skin (Review)

Piérard¹

1998

Int J Mol Med

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Abstract. The human dermis contains a series of dendritic cells which express different phenotypes including Factor XIIIa immunoreactivity. This compound is related to a blood coagulation factor participating in angiogenesis, in the final stages of the clotting cascade and in wound healing. In normal skin, Factor XIIIa is expressed in specific dermal dendrocytes (DD) derived from the monocyte/macrophage lineage or from a mesenchymal origin. DD are located predominantly around the microvasculature in the adventitial dermis, at the dermo-epidermal junction, and around skin appendages, but normally not within the epidermis. Increased numbers of Factor XIIIa + DD are present in a host of specific cutaneous inflammatory and fibrotic conditions. In tumor pathology, immunophenotypic differences are found between dermatofibromas and other fibrohistiocytic entities, most notably dermatofibrosarcoma protuberans. In addition, Factor XIIIa + DD are likely to be involved in the progression and regression of some malignancies including cutaneous melanoma and basal cell carcinoma.

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Is There a Link between Dendrocytes, Fibrosis and Sclerosis?

Cited by 35 publications

References 7 publications

Dermal Dendritic Cell Population and Blood Vessels Are Diminished in the Skin of Systemic Sclerosis Patients

Dermal Dendritic Cell Population and Blood Vessels Are Diminished in the Skin of Systemic Sclerosis Patients

Inverse modulation of intraepithelial Langerhans' cells and stromal macrophage/dendrocyte populations in human papillomavirus-associated squamous intraepithelial lesions of the cervix

Molecular mapping of Factor XIIIa-enriched dendrocytes in the skin (Review)

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