Is there a link between inflammation and abnormal lipoprotein profile in Sjögren's syndrome?

Cruz, Willian; Fialho, Sônia Cristina de Magalhães Souza; Morato, Edelton Flávio; Castro, Gláucio Ricardo Werner de; Zimmermann, Adriana Fontes; Ribeiro, Giovana Gomes; Neves, Fabrício Souza; Pereira, Ivânio Alves

doi:10.1016/j.jbspin.2010.02.011

Cited by 20 publications

(10 citation statements)

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“…In multivariate models, age was an independent predictor of both arterial wall thickening and plaque formation, and lymphopenia was an independent risk factor for plaque formation. Although increased prevalence of DM [ 29 ], hypertriglyceridemia [ 29 , 30 ], HT [ 30 ] and dyslipidemia [ 31 , 32 ] were previously reported to be higher among SS populations, we have not observed significant differences between patients with primary SS and HC, except for lower rates of family history of CVD and cholesterol levels in the primary SS group. The latter observation was also supported by Lodde et al .…”

Section: Discussioncontrasting

confidence: 70%

Subclinical atherosclerosis and impaired bone health in patients with primary Sjogren’s syndrome: prevalence, clinical and laboratory associations

Gravani¹,

Papadaki²,

Antypa³

et al. 2015

Arthritis Res Ther

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IntroductionTo determine the prevalence and clinical/laboratory associations of subclinical atherosclerosis and impaired bone health in primary Sjogren’s syndrome (SS).Methods64 consecutive patients with primary SS, 77 with rheumatoid arthritis (RA) and 60 healthy controls (HC) οf similar age and sex distribution were enrolled. Demographics, clinical/laboratory features, classical risk factors for atherosclerosis and osteoporosis (OP) were recorded. Intima-medial thickness scores (IMT) and carotid/femoral (C/F) plaque formation, as well as bone mineral density (BMD) and fractures were evaluated. Determinants of IMT/BMD levels and the presence of plaque were assessed by univariate and multivariate models. Serum levels of the Wnt signaling mediators Dickkopf-related protein 1(DKK1) and sclerostin were determined in primary SS patients and HC.ResultsIncreased arterial wall thickening (IMT > 0.90 mm) and impaired bone health (defined as OP or osteopenia), were detected in approximately two-thirds of primary SS and RA patients, with a mean IMT value being significantly increased compared to HC. The presence of primary SS emerged as an independent risk factor for arterial wall thickening when traditional risk factors for cardiovascular disease (CVD) including age, sex, hypertension, smoking (pack/years), LDL and HDL levels were taken into account in a multivariate model [adjusted OR 95% (CI): 2.8 (1.04-7.54)]. In primary SS, age was revealed as independent predictor of increased IMT scores; age and lymphopenia as well as increased urine pH as independent determinants of C/F plaque formation and OP/osteopenia, respectively. An independent association of OP/osteopenia with plaque formation was observed when independent predictors for both variables were considered, with low DKK1 levels being associated with both plaque formation and lower BMD levels.ConclusionsComorbidities such as subclinical atherosclerosis and impaired bone health occur frequently in primary SS, in association with disease related features and traditional risk factors. Wnt signaling mediators are potentially involved in the pathogenesis of both entities.Electronic supplementary materialThe online version of this article (doi:10.1186/s13075-015-0613-6) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 70%

Subclinical atherosclerosis and impaired bone health in patients with primary Sjogren’s syndrome: prevalence, clinical and laboratory associations

Gravani¹,

Papadaki²,

Antypa³

et al. 2015

Arthritis Res Ther

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“…The potential interesting relationship between this metabolic alteration and pSS-related inflammatory/immunological features is also supported by a number of observations. Higher antinuclear antibody positivity, a marker of immune system hyperactivity, and higher levels of erythrocyte sedimentation rate, which reflects a chronic inflammatory state, have been demonstrated in pSS subjects with dyslipidaemia and hypertriglyceridaemia, respectively, compared to normolipidaemic patients [25,31]. Moreover, total cholesterol and HDL-c levels are predictive of increased immunoglobulin G serum concentration, which is an indirect marker of B lymphocyte hyperactivity, and low levels of total cholesterol and HDL-c have been mainly observed in anti-SSA/SSB-positive patients [13,30].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular disease risk burden in primary Sjögren's syndrome: results of a population‐based multicentre cohort study

et al. 2015

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Abstract. Bartoloni E, Baldini C, Schillaci G, Quartuccio L, Priori R, Carubbi F, Bini V, Alunno A, Bombardieri S, De Vita S, Valesini G, Giacomelli R, Gerli R (University of Perugia, Perugia; University of Pisa, Pisa; Terni University Hospital, Terni; University of Udine, Udine; Sapienza University of Rome, Rome; University of L'Aquila, L'Aquila; and University of Perugia, Perugia; Italy). Cardiovascular disease risk burden in primary Sj€ ogren's syndrome: results of a population-based multicentre cohort study. J Intern Med 2015; 278: 185-192.Objective. Systemic autoimmune diseases, in particular systemic lupus erythematosus and rheumatoid arthritis, are characterized by a high risk of premature cardiovascular (CV) events. Diseaserelated characteristics and traditional CV disease risk factors may contribute to atherosclerotic damage. However, there are limited data on the risk of overt CV events in primary Sj€ ogren's syndrome (pSS).Methods. We retrospectively analysed a cohort of patients with 1343 pSS. Disease-related clinical and laboratory data, traditional CV disease risk factors and overt CV events were recorded. Prevalence of traditional CV disease risk factors and of major CV events was compared between a subgroup of 788 female patients with pSS aged from 35 to 74 years and 4774 age-matched healthy women.Results. Hypertension and hypercholesterolaemia were more prevalent, whereas smoking, obesity and diabetes mellitus were less prevalent, in women with pSS than in control subjects. Cerebrovascular events (2.5% vs. 1.4%, P = 0.005) and myocardial infarction (MI) (1.0% vs. 0.4%, P = 0.002) were more common in patients with pSS. In the whole population, central nervous system involvement (odds ratio (OR) 5.6, 95% confidence interval (CI) 1.35-23.7, P = 0.02) and use of immunosuppressive therapy (OR 1.9, 95% CI 1.04-3.70, P = 0.04) were associated with a higher risk of CV events. Patients with leucopenia had a higher risk of angina (P = 0.01).Conclusions. pSS is associated with an increased risk of cerebrovascular events and MI. Disease-related clinical and immunological markers may have a role in promoting CV events.

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“…These patients frequently present an abnormal lipid profile, due to the augmented inflammatory burden of these diseases, which partially explains why they are at a greater cardiovascular risk. In a recent study by Cruz, et al, it was suggested that patients with pSS may quite often present an abnormal lipid profile, which is associated with elevated levels of acute-phase reactants such as erythrocyte sedimentation rate 40 . In the study by Borba and Bonfá, active disease enhanced an increase in VLDL and TG levels and a decrease in HDL levels, compared to patients with inactive SLE 25 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Hydroxychloroquine on the Lipid Profile of Patients with Sjögren Syndrome

Migkos

Markatseli²,

Iliou³

et al. 2014

J Rheumatol

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Is there a link between inflammation and abnormal lipoprotein profile in Sjögren's syndrome?

Cited by 20 publications

References 15 publications

Subclinical atherosclerosis and impaired bone health in patients with primary Sjogren’s syndrome: prevalence, clinical and laboratory associations

Subclinical atherosclerosis and impaired bone health in patients with primary Sjogren’s syndrome: prevalence, clinical and laboratory associations

Cardiovascular disease risk burden in primary Sjögren's syndrome: results of a population‐based multicentre cohort study

Effect of Hydroxychloroquine on the Lipid Profile of Patients with Sjögren Syndrome

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