Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction?

Rodean, Ioana-Patricia; Biriș, Carmen-Ioana; Halațiu, Vasile-Bogdan; Modiga, Andrei; Lazăr, Luminița; Benedek, Imre; Benedek, Theodora

doi:10.3390/life11101050

Cited by 9 publications

(7 citation statements)

References 82 publications

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“…Several articles refer to the possibility that patients with periodontal disease are more susceptible to COVID-19 infection because they already have over-expression of the ACE-2 receptor, implicated in the entry of SARS-CoV-2 in the host [ 16 , 21 , 23 , 28 , 31 – 41 ].…”

Section: Resultsmentioning

confidence: 99%

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Impact of COVID-19 on Periodontitis and Peri-Implantitis: A Narrative Review

Mancini¹,

Americo²,

Pizzolante³

et al. 2022

Front. Oral. Health

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COVID-19 is reported as one of the most widespread diseases in the world. An extraordinary number of articles and manuscripts have focused on the inflammatory cascade and sequelae, showing the important roles of cytokines and renin-angiotensin levels and possible links to other pathologies. Nowadays, interest regarding the possible correlation between COVID-19 and periodontal and Peri-implant diseases is increasing. This mini-review aims to collect data regarding the possible correlation between COVID-19 and periodontitis or Peri-implantitis through the analysis of articles published in the last 3 years. The following keywords were used: ([periodontitis OR periodontal disease] AND [COVID-19]); ([Peri-implantitis OR mucositis] AND [COVID-19 OR Sars-CoV-2]). The inclusion criteria were studies on COVID-19 or SARS-CoV-2 and periodontitis or Peri-implantitis, and studies on the molecular and cellular aspect of COVID-19 in periodontal or Peri-implant tissues. The search revealed 484 articles in total (PubMed 208 and Scopus 276). After a screening of titles and abstracts, 47 articles were included in the full-text analysis. Two articles comprised the Peri-implant group: a short communication and a review. Regarding the periodontal group, 45 articles were selected and analyzed according to the type of study, population, and aim. Of these, 10 articles were clinical studies, and the other 35 were hypotheses, reviews, letters to the editor, or commentaries. In conclusion, according to the data extracted, a mutual correlation between COVID-19 and periodontitis can be stated; however, data linked to Peri-implantitis are still missing, and future clinical studies are still needed.

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Section: Resultsmentioning

confidence: 99%

“…Inflammation, and thus increases in cytokines (such as IL1, IL6, IL8) typical of periodontitis, is the link with COVID-19; it may also aggravate the conditions of COVID-19 infection [ 23 , 26 , 28 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

Impact of COVID-19 on Periodontitis and Peri-Implantitis: A Narrative Review

Mancini¹,

Americo²,

Pizzolante³

et al. 2022

Front. Oral. Health

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“…In the aftermath of the COVID-19 pandemic, numerous studies ( 3 ) ( 54 – 56 ) have surfaced suggesting a potential connection between periodontitis and COVID-19, both of which appear to induce and exacerbate various cardiometabolic complications ( 57 ). The nexus between COVID-19 and PD is intricate and multifaceted, with evidence implying a shared inflammatory pathophysiology ( 58 ). This inflammation can instigate endothelial dysfunction, oxidative stress, and coagulation irregularities, thereby fostering the onset of cardiometabolic complications ( 59 ), including cardiovascular disease, type 2 diabetes, and metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric research on analysis of links between periodontitis and cardiovascular diseases

Tang,

Wu,

Zheng

et al. 2023

Front. Cardiovasc. Med.

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BackgroundPeriodontitis (PD) and cardiovascular diseases (CVD) rank among the most prevalent pathologies worldwide, and their correlation has been a subject of prolonged investigation. Numerous studies suggest shared etiological factors; however, a definitive causal connection remains unestablished. The objective of this study was to employ bibliometric and visual analyses in order to comprehensively examine the overarching characteristics, focal areas of research, and prospective trends pertaining to the PD-CVD relationship.MethodsWe sourced articles, reviews, and online publications on PD- and CVD- research from the Web of Science Core Collection (WoSCC) spanning from January 1, 1993, to May 15, 2023. A triad of analytical tools (R-Bibliometrix, VOSviewer 1.6.19, and CiteSpace 6.2.R3) were utilized to facilitate collaboration network analysis, co-citation analysis, co-occurrence analysis, and citation burst detection.ResultsOut of the 1,116 publications that fulfilled the eligibility criteria in the WoSCC database, the comprehensive characteristics analysis divulged a sustained growth trend in publication frequency. In the cluster analysis of reference co-citation and keyword co-occurrence, prominent themes such as “periodontitis”, “cardiovascular diseases”, “inflammation”, “Porphyromonas gingivalis”, and “atherosclerosis” consistently emerged. Contemporary topics such as “peri-implantitis,” “COVID-19”, “cardiovascular risk factors,” and “endocarditis” were pinpointed as burgeoning research hotspots.ConclusionBased on this bibliometric study, in the field of association studies between PD and CVD, the etiologic mechanisms of both diseases have been intensively studied in the last three decades. Periodontal pathogens might serve as potential initiating factors linking PD and CVD. Inflammation may constitute a significant etiological factor shared by both diseases. Several emerging topics, such as COVID-19 and peri-implantitis, exhibit promising potential. This exhaustive overview casts light on pivotal research arenas, augmenting the field's understanding and stimulating further scholarly investigations.

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“…This ultimately leads to cardiac cachexia, which worsens the patient's prognosis [14,15]. On the other hand, both AMI and nutritional deficiency are associated with an increased inflammatory status; persistence of high inflammation in the postinfarction period may have a detrimental effect not only on the ventricular function, but also in the patient's prognosis [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Status and Recurrent Major Cardiovascular Events Following Acute Myocardial Infarction—A Follow-Up Study in a Primary Percutaneous Coronary Intervention Center

Czinege,

Halațiu,

Nyulas

et al. 2024

Nutrients

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Background: Acute myocardial infarction is often accompanied by malnutrition, which is associated with an imbalance between catabolic and anabolic processes. This ultimately leads to cardiac cachexia, which worsens the patient’s prognosis. We aimed to assess the correlation between nutritional status, assessed using the controlling nutritional status (CONUT) score, and the rate of major cardiovascular adverse events (MACE). Methods: The present investigation was a non-randomized, prospective, observational study in which 108 patients with acute myocardial infarction were included. Nutritional status was assessed using the CONUT score. Based on the CONUT score, the patients were divided as follows: Group 1—normal or mild nutritional status (CONUT < 3 points, n = 76), and Group 2—moderate to severe nutritional deficiency (CONUT ≥ 3 points, n = 32). Demographic, echocardiographic, and laboratory parameters were obtained for all patients, as well as the MACE rate at 1 and 3 months of follow-up. Results: The MACE occurred more frequently in patients with impaired nutritional status at both 1-month follow-up (46.9% versus 9.2%; p < 0.0001) and 3-month follow-up (68.8% versus 10.5%; p < 0.0001). In terms of cardiovascular events, patients with poor nutritional status, with a CONUT score ≥ 3, presented more frequent non-fatal myocardial infarction, stroke, revascularization procedure, and ventricular arrhythmia. Also, the number of cardiovascular deaths was higher in the undernourished group. Conclusions: This study found that patients with poor nutritional status experienced inflammatory status, frailty, and cardiovascular events more often than those with normal nutritional status at 1-month and 3-month follow-up after an acute myocardial infarction.

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Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction?

Cited by 9 publications

References 82 publications

Impact of COVID-19 on Periodontitis and Peri-Implantitis: A Narrative Review

Impact of COVID-19 on Periodontitis and Peri-Implantitis: A Narrative Review

Bibliometric research on analysis of links between periodontitis and cardiovascular diseases

Nutritional Status and Recurrent Major Cardiovascular Events Following Acute Myocardial Infarction—A Follow-Up Study in a Primary Percutaneous Coronary Intervention Center

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