Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?

Aas, Monica; Navari, Serena; Gibbs, Ayana A.; Mondelli, Valeria; Fisher, Helen L.; Morgan, Craig; Morgan, Kevin; MacCabe, James H.; Reichenberg, Abraham; Zanelli, Jolanta; Fearon, Paul; Jones, Peter B.; Murray, Robin M.; Pariante, Carmine M.; Dazzan, Paola

doi:10.1016/j.schres.2012.01.035

Cited by 108 publications

(72 citation statements)

References 47 publications

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“…In individuals with first-episode of psychosis, exposure to childhood trauma has been associated with worse cognitive function and smaller amygdala (Aas et al 2012), or decreased hippocampal volume (Hoy et al 2012). Sexual abuse has been specifically associated with reduced (total) grey matter volume in psychotic patients compared to healthy participants (Sheffield et al 2013), whereas, in line with Carrion et al (2001), psychotic cases with a history of childhood trauma showed bilateral reduction of the PFC relative to cases without trauma history.…”

Section: Pro-inflammatory Markers In Schizophrenia and Bipolar Disordermentioning

confidence: 99%

Stress, Schizophrenia and Bipolar Disorder

Green

Girshkin

Teroganova

et al. 2014

Behavioral Neurobiology of Stress-Related Disorders

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The role of stress in precipitating psychotic episodes in schizophrenia and bipolar disorder has long been acknowledged. However, the neurobiological mechanism/s of this association have remained elusive. Current neurodevelopmental models of psychosis implicate early dysfunction in biological systems regulating hypothalamic-pituitary-adrenal axis and immune function, with long-term effects on the development of the brain networks responsible for higher order cognitive processes and stress reactivity in later life. There is also increasing evidence of childhood trauma in psychosis, and its impact on the development of brain systems regulating stress. These findings are emerging in the context of a new era of epigenetic methods facilitating the study of environmental effects on gene expression. The evidence is thus converging: exposure to stress at critical periods in life may be an important factor in the development of the brain dysfunction that represents psychosis vulnerability, rather than merely interacting with an independent 'biological vulnerability' to manifest in psychosis.

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Section: Pro-inflammatory Markers In Schizophrenia and Bipolar Disordermentioning

confidence: 99%

Stress, Schizophrenia and Bipolar Disorder

Green

Girshkin

Teroganova

et al. 2014

Behavioral Neurobiology of Stress-Related Disorders

View full text Add to dashboard Cite

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“…Volumetric reductions in the amygdala (Soloff et al 2008;Aas et al 2012a;Hoy et al 2012), hippocampus (Hoy et al 2012), ventrolateral prefrontal cortex (Morandotti et al 2013) and in total grey matter (Sheffield et al 2013) have been reported among patients with psychotic disorders and borderline personality disorder with a history of childhood trauma compared with those without such a history. Structural brain changes as a result of childhood maltreatment have been associated with the severity of substance use relapse (Van Dam et al 2014), which may represent a significant problem given the high rates of such disorders reported among psychosis and borderline personality disorder cohorts (Regier et al 1990;Trull et al 2000).…”

Section: Brain Developmentmentioning

confidence: 99%

Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature

Cotter

Kaess

Yung

2014

Ir. j. psychol. Med.

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Objectives. We aimed to examine the association between childhood trauma and functional impairment in psychotic disorders, bipolar disorder and borderline personality disorder, to speculate on possible mechanisms that underlie this association and discuss the implications for clinical work.Methods. Narrative review of the peer-reviewed English language literature in the area.Results. High rates of childhood trauma in psychotic disorders, bipolar disorder and borderline personality disorder were identified. This was associated with impaired social and occupational functioning in both the premorbid and established phases of each of these psychiatric disorders over and above the deficits typically observed in these populations. Possible mechanisms mediating this relationship include neurocognitive deficits, insecure attachment, higher rates of comorbidities and problems with adherence and response to treatment. Conclusions.Routine clinical inquiry about childhood maltreatment should be adopted within mental health settings. This has potentially important treatment implications for identifying those individuals at elevated risk of functional disability. While there is no clear guidance currently available on how to target childhood trauma in the treatment of psychotic disorders, bipolar disorder or borderline personality disorder, there are several promising lines of enquiry and further research is warranted.

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“…Animal models provided initial evidence of a lasting impact of ELT on the limbic system (LeDoux, 2000, 2003). Human brain imaging studies subsequently showed that I‐ELT was associated with altered structural integrity in the limbic system (Aas et al., 2012; Andersen et al., 2008; Bremner et al., 1997; Carrion, Weems, & Reiss, 2007; Corbo et al., 2014; Dannlowski et al., 2012; Driessen et al., 2004; Lupien et al., 2011; Tottenham et al., 2010; Veer et al., 2015). Functional imaging studies have further shown that, when processing emotional stimuli (e.g., angry faces), I‐ELT was associated with increased activity in the amygdala (Bremner et al., 2005; Grant, Cannistraci, Hollon, Gore, & Shelton, 2011; Maheu et al., 2010), and with decreased activity of the hippocampus (Bremner et al., 1999; Bremner et al., 2003; Carrion, Haas, Garrett, Song, & Reiss, 2010) and anterior cingulate cortex (Bremner, Vythilingam, Vermetten, Southwick, McGlashan, Nazeer, et al., 2003; Bremner, et al., 2003; Bremner et al., 2004; Mueller et al., 2010).…”

Section: Introductionmentioning

confidence: 99%

Interpersonal early‐life trauma alters amygdala connectivity and sustained attention performance

et al. 2017

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IntroductionInterpersonal early life trauma (I‐ELT) is associated with a myriad of functional impairments in adulthood, increased risk of drug addiction, and neuropsychiatric disorders. While deficits in emotional regulation and amygdala functioning are well characterized, deficits in general cognitive functioning have also been documented. However, the neural underpinnings of cognitive dysfunction in adults with a history of I‐ELT and the potential relationship between amygdala‐based functional connectivity and behavioral performance are currently poorly understood. This study examined how I‐ELT affects the cognitive and neural mechanisms supporting sustained attention.MethodsA total of 66 Veterans (18 with and 48 without a history of I‐ELT) completed a nonemotional sustained attention task during functional MRI.ResultsThe individuals with I‐ELT showed significant impairments in sustained attention (i.e., higher error rates, greater response variability). This cohort exhibited increased amygdala functional connectivity with the prefrontal cortex and decreased functional connectivity with the parahippocampal gyrus when compared to those without I‐ELT. These connections were significantly correlated with individual differences in sustained attention performance. Notably, classification analyses revealed that the pattern of amygdala connectivity across the whole brain was able to classify I‐ELT status with 70% accuracy.ConclusionThese results provide evidence of a lasting negative impact for those with a history of I‐ELT on sustained attention ability. They also highlight a critical role for amygdala functioning in cognitive control and sustained attention for those with a history of I‐ELT, which may underlie the observed attention deficits in clinical assessments and cognitive tests involving both emotional and nonemotional stimuli.

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Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?

Cited by 108 publications

References 47 publications

Stress, Schizophrenia and Bipolar Disorder

Stress, Schizophrenia and Bipolar Disorder

Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature

Interpersonal early‐life trauma alters amygdala connectivity and sustained attention performance

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