Is There a Link between Wheezing in Early Childhood and Adverse Birth Outcomes? A Systematic Review

Patelarou, Evridiki; Chochlidaki, Maria; Vivilaki, Victoria; Brokalaki, Hero

doi:10.3390/ijerph6112752

Cited by 9 publications

(9 citation statements)

References 39 publications

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“…Furthermore, restriction of the analyses to children born at term reduced the association for maternal CD-related admissions, suggesting that the association may be attributable to maternal pregnancy complications, rather than IBD, causing respiratory symptoms in small children. 32 …”

Section: Discussionmentioning

confidence: 99%

Parental Inflammatory Bowel Disease and Risk of Asthma in Offspring: A Nationwide Cohort Study in Denmark

Andersen

Ehrenstein

Erichsen

et al. 2013

Clinical and Translational Gastroenterology

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OBJECTIVES:Common genetic and environmental risk factors may explain the concurrent increase in the incidence of both inflammatory bowel disease (IBD) and asthma. We examined whether IBD in a parent is associated with an increased asthma risk in offspring.METHODS:This was a registry-based cohort study of all children born alive in Denmark in 1979–2009, followed through 2010. IBD and asthma were identified using hospital diagnoses; antiasthma medication was also used to identify asthma. We computed risk of asthma and estimated adjusted incidence rate ratios (aIRRs) with 95% confidence intervals (CIs) using Cox proportional-hazards regression. We evaluated asthma risk according to maternal and paternal IBD, Crohn's disease (CD), and ulcerative colitis (UC). Children without parental IBD were the comparison cohort for all comparisons.RESULTS:We identified 1,845,281 children, of whom 14,952 (0.8%) had a parent with IBD. The 10-year risk of asthma was 6.9% among offspring of parents with CD, 5.6% among offspring of parents with UC, and 5.0% among offspring of parents without IBD. The aIRR for asthma associated with parental IBD was 0.98 (95% CI: 0.91–1.04). The aIRR was 1.09 (95% CI: 0.98–1.22) for parental CD and 0.92 (95% CI: 0.84–1.00) for parental UC. Results were similar regardless of parent of origin or inclusion of antiasthma medication to define asthma.CONCLUSIONS:Our data do not provide evidence for an increased risk of asthma in offspring with a parental history of IBD.

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Section: Discussionmentioning

confidence: 99%

Parental Inflammatory Bowel Disease and Risk of Asthma in Offspring: A Nationwide Cohort Study in Denmark

Andersen

Ehrenstein

Erichsen

et al. 2013

Clinical and Translational Gastroenterology

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“…We classified breastfeeding into none, any and all months. Adverse pregnancy outcomes were not included as covariates because they could be on the causal pathway between maternal alcohol intake and early childhood respiratory disorders (Jaakkola et al, 2006; Odendaal et al, 2009; Patelarou et al, 2009; Patra et al, 2011). …”

Section: Methodsmentioning

confidence: 99%

Prospective Study of Maternal Alcohol Intake During Pregnancy or Lactation and Risk of Childhood Asthma: The Norwegian Mother and Child Cohort Study

Magnus

DeRoo

Håberg

et al. 2014

Alcoholism Clin & Exp Res

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Background Many women drink during pregnancy and lactation despite recommendations to abstain. In animals, alcohol exposure during pregnancy and lactation influences lung and immune development, plausibly increasing risk of asthma and lower respiratory tract infections (LRTIs). Studies in humans are few. Methods In the Norwegian Mother and Child Cohort Study, we examined maternal alcohol intake during pregnancy and lactation in relation to risk of current asthma at 36 months (49,138 children), recurrent LRTIs by 36 months (39,791 children) and current asthma at seven years (13,253 children). Mothers reported frequency and amount of alcohol intake each trimester and the first three months following delivery. We calculated adjusted relative risks (aRR), comparing children of drinkers to non-drinkers, using Generalized Linear Models. Results A total of 31.8% of mothers consumed alcohol during first trimester, 9.7% during second trimester and 15.6% during third trimester. Infrequent and low-dose prenatal alcohol exposure showed a modest statistically significant inverse association with current asthma at 36 months (aRRs ~0.85). No association was seen with the highest alcohol intakes during the first trimester when alcohol consumption was most common. Relative risks of maternal alcohol intake during pregnancy with recurrent LRTIs were ~1, with sporadic differences in risk for some metrics of intake, but without any consistent pattern. For current asthma at seven years, similar inverse associations were seen as with current asthma at 36 month but were not statistically significant. Among children breastfed throughout the first three months of life, maternal alcohol intake during this time was not significantly associated with any of the three outcomes. Conclusion The low levels of alcohol exposure during pregnancy or lactation observed in this cohort were not associated with increased risk of asthma or recurrent LRTIs. The slight inverse associations of infrequent or low-dose prenatal alcohol exposure with asthma may not be causal.

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“…This increase may be closely associated with exposure to allergens (particularly pollens, molds, dust, and pet dander), tobacco smoke, exercise, air pollutants, and respiratory infections, but has yet to be fully explained [ 3 ]. Furthermore, children with low birth weight are prone to developing decreased respiratory function and having an increased risk of chronic respiratory symptoms during childhood [ 4 ]. Previous studies have shown that some prenatal or perinatal adverse factors could be associated with the development of asthma later in life [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, children with low birth weight are prone to developing decreased respiratory function and having an increased risk of chronic respiratory symptoms during childhood [ 4 ]. Previous studies have shown that some prenatal or perinatal adverse factors could be associated with the development of asthma later in life [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of low birth weight on childhood asthma: a meta-analysis

Sheng

et al. 2014

BMC Pediatr

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BackgroundLow birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.MethodsA systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case–control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.ResultsThirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128–1.197) and 1.152 (random-effects model, 95% CI, 1.082–1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.ConclusionsThis meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

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Is There a Link between Wheezing in Early Childhood and Adverse Birth Outcomes? A Systematic Review

Cited by 9 publications

References 39 publications

Parental Inflammatory Bowel Disease and Risk of Asthma in Offspring: A Nationwide Cohort Study in Denmark

Parental Inflammatory Bowel Disease and Risk of Asthma in Offspring: A Nationwide Cohort Study in Denmark

Prospective Study of Maternal Alcohol Intake During Pregnancy or Lactation and Risk of Childhood Asthma: The Norwegian Mother and Child Cohort Study

Effect of low birth weight on childhood asthma: a meta-analysis

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