Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?

Navolan, Dan; Nicolov, Mirela; Vlădăreanu, Simona; Ciohat, Ioana; Craina, Marius; Tomovic, Miroslav; Nemescu, Dragoş; Onofriescu, Alina; Craciunescu, Mihaela; Bîrsăşteanu, Florin

doi:10.37358/rc.17.5.5613

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…Future studies should, therefore, confirm this decreasing trend in seroprevalence for T. gondii. We include screening for TORCH agents along with first and second trimester screening in antenatal care program (41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

A decreasing trend in toxoplasma gondii seroprevalence among pregnant women in Romania�‑�results of a large scale study

et al. 2020

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Toxoplasmosis is a zoonotic infection caused by the obligate intracellular apicomplexan parasite Toxoplasma gondii (T. gondii). T. gondii infection is a cause of congenital infection worldwide. Primary infection or the reactivation of latent infection during pregnancy may lead to fetal infection and to congenital toxoplasmosis syndrome. Seropositive pregnant women are generally protected from maternal-fetal transmission of T. gondii , although exceptions exist. The aim of our study was to analyze the dynamics of T. gondii seroprevalence during a 10-year period and to correlate it with age and demographic features of pregnant women. We tested 6,889 pregnant women in Timisoara, Romania, for IgG-anti- T. gondii antibodies, in two successive periods: i) 2008-2010 (group 1: 1,457 participants); and ii) 2015-2018 (group 2: 5,432 participants). For each participant, data on age and area of residence were collected. Our results showed that in the Western Region of Romania T. gondii seroprevalence in pregnant women declined from 43.79 to 38.81% in the last ten years. This trend was observed in both urban (40.53 vs. 34.85%) and rural areas (52.22 vs. 46.22%). A higher seroprevalence rate was found in rural than in urban areas. In addition, we found an increasing tendency of seroprevalence related to the age of pregnant women.

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Section: Discussionmentioning

confidence: 99%

A decreasing trend in toxoplasma gondii seroprevalence among pregnant women in Romania�‑�results of a large scale study

et al. 2020

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“…We searched the link between lipidic changes in pregnancies with PE and the way prophylactic treatments with acetylsalicilic acid or low molecular weight heparines can influence the evolution of pregnancy, avoiding the severe complications of this disease.Changes in lipid metabolism from pregnancies with preeclampsia are a challenge for the obstetrician, because they contribute to the pathological chain and to some specific severe complications (severe hypertriglyceridemia of pregnancy, acute pancreatitis etc) [3]. The histopathological exams revealed the accumulation of lipidloaded macrophages in the affected endothelium [4,5].In normal pregnancy, an activation by resetting the hypothalamic lipostat, which causes hyperlipidemia [6] is described. Lipid alterations are more marked in pregnant women with PE and major changes are seen in triglycerides-hypertriglyceridemia.…”

mentioning

confidence: 99%

“…Changes in lipid metabolism from pregnancies with preeclampsia are a challenge for the obstetrician, because they contribute to the pathological chain and to some specific severe complications (severe hypertriglyceridemia of pregnancy, acute pancreatitis etc) [3]. The histopathological exams revealed the accumulation of lipidloaded macrophages in the affected endothelium [4,5].…”

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confidence: 99%

A Biochemical Marker of Preeclampsia - Hypertriglyceridemia - and the Impact of Secondary Prevention Therapy

Grigoriu¹,

Furtunescu²,

Găman³

et al. 2018

Rev. Chim.

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Changes in lipid metabolism from pregnancies with preeclampsia (PE) are a challenge for the obstetrician, because they contribute to the pathological chain and to some specific severe complications (severe hypertriglyceridemia of pregnancy, acute pancreatitis etc). Patients at risk for PE have higher levels of triglycerides, total and LDL cholesterol, compared to normotensive pregnant women. We searched the link between lipidic changes in pregnancies with PE and the way secondary prophylactic treatments with acetylsalicilic acid or low molecular weight heparin (LMWH) can influence the evolution of pregnancy, avoiding the severe complications of this disease. We identified patients at risk of developing PE and then applied a secondary prophylaxis with either a platelet antiaggregant (acetylsalycilic acid - a group of 36 patients) or an anticoagulant prophylaxis with LMWH � enoxaparin (a second group of 37 patients), aiming a decrease of severe complications of PIH/PE. The control group consisted of 33 pregnant women with risk factors for PE, without any secondary prophylaxis, according to actual guidelines. We periodically determined (at 14, 16-20 and 34 weeks of pregnancy) several biochemical parameters: triglycerides, uric acid, free fatty acids, total cholesterol and albuminemia. In the present paper we present the evolution of triglyceridemia in the studied groups, considering hypertriglyceridemia as an important prognostic factor for maternal complications in pregnancy. The most important result of our study is the statistically significant extremely low rate of complications in the treatment groups.

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“…Further studies should be performed on better characterized groups of patients to evaluate the course of IgG-anti-F(ab')2 antibodies along pregnancy and their role in spontaneous abortion or other pregnancy complications. Considering the risks to the fetus in pregnant women with anti-thyroide antibodies [4][5][6][7], we recommend performing the screening for thyroid pathology together with the other screenings [23][24][25].…”

Section: Igg-anti-f(ab)2 Atbs Titer Is Higher In Women With a Normal Course Of Pregnancy Compared To Women Who Experienced A Spontaneous mentioning

confidence: 99%

IgG anti-(Fab�)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions

Motoi¹,

Dobrescu²,

Carabineanu³

et al. 2020

Rev. Chim.

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Anti-thyroid antibodies (atbs) (anti-TPO, anti-TG, anti-TRH receptor) are autoatbs that recognize specific antigens that belong to thyroid structures. Several mechanisms were proposed to explain the breaking of immunotolerance to thyroid antigens. Our previous studies showed that IgG-anti-F(ab�)2 atbs exert immunosuppresives effect in vitro and inverse correlate with autoatbs in certain autoimmune diseases. Relying on sera from pregnant women with and without anti-thyroid atbs, respectively with or without spontaneous pregnancy loss we intended to analyze the IgG-anti-F(ab)2 atbs titers in sera of these categories of patients. The lot of patients consists of 126 pregnant women out of which 47 had a normal course of pregnancy and 79 experienced spontaneous abortion. Anti-TPO, anti-TG, and IgG-anti-F(ab�)2 atbs titers were measured in sera of these women. Although a difference was found between IgG-anti-F(ab�)2 atbs titer in pregnant women with positive versus negative anti-thyroid atbs, this was not statistically significant. IgG-anti-F(ab)2 atbs titer is higher in women with a normal course of pregnancy compared to women spontaneous pregnancy loss. Differently from other autoimmune diseases, our data show that IgG-anti-F(ab�)2 atbs are not inversely correlated to anti-thyroid atbs titers. Higher IgG-anti-(Fab�)2 atbs titers were found in pregnant women with normal course of pregnancy compared with those with pregnancy loss.

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Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?

Cited by 4 publications

References 7 publications

A decreasing trend in toxoplasma gondii seroprevalence among pregnant women in Romania�‑�results of a large scale study

A decreasing trend in toxoplasma gondii seroprevalence among pregnant women in Romania�‑�results of a large scale study

A Biochemical Marker of Preeclampsia - Hypertriglyceridemia - and the Impact of Secondary Prevention Therapy

IgG anti-(Fab�)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions

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