Is There a Nonadditive Interaction Between Spontaneous and Evoked Activity? Phase-Dependence and Its Relation to the Temporal Structure of Scale-Free Brain Activity

Huang, Zirui; Zhang, Jianfeng; Longtin, André; Dumont, Grégory; Duncan, Niall W.; Pokorny, Johanna; Qin, Pengmin; Dai, Ruwei; Ferri, Francesca; Weng, Xuchu; Northoff, Georg

doi:10.1093/cercor/bhv288

Cited by 97 publications

(191 citation statements)

References 88 publications

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…2) We did not observe widespread TTV reduction across the entire cortex as previously shown [He, 2013; Huang et al, 2017]. This may be due to the simplicity of the task with lower cognitive load and task demands, as well as a relatively lower number of trials in a sparse-event related design within limited clinical fMRI scanning time.…”

Section: Discussionsupporting

confidence: 57%

“…Each audio clip was followed by inter-trial-intervals (ITIs) ranging unpredictably from 15.5 to 25.5s (2s-step). The benefit of long ITIs was avoiding potential nonlinearities associated with overlapping hemodynamic responses between preceding and subsequent trials, especially for trial-to-trial variability calculation [Huang et al, 2017]. All stimuli were programmed using E-Prime 2.0 (Psychology Software Tools, Pittsburgh, PA) and delivered via an audiovisual stimulus presentation system designed for an MRI environment.…”

Section: Methodsmentioning

confidence: 99%

“…TTV reduction has been consistently observed in cellular recordings [Chang et al, 2012; Churchland et al, 2010; Finn et al, 2007; Monier et al, 2003; Scaglione et al, 2011; White et al, 2012], EEG/ECoG [He and Zempel, 2013; Schurger et al, 2015], and fMRI [Ferri et al, 2015; He, 2013; Huang et al, 2017]. These data were collected across a variety of species and brain areas and under a broad range of stimulus conditions suggesting that TTV reduction driven by stimulation or task was a widespread neural phenomenon.…”

Section: Introductionmentioning

confidence: 90%

See 2 more Smart Citations

Disrupted neural variability during propofol‐induced sedation and unconsciousness

Huang

Zhang

et al. 2018

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

Variability quenching is a widespread neural phenomenon in which trial-to-trial variability (TTV) of neural activity is reduced by repeated presentations of a sensory stimulus. However, its neural mechanism and functional significance remain poorly understood. Recurrent network dynamics are suggested as a candidate mechanism of TTV, and they play a key role in consciousness. We thus asked whether the variability-quenching phenomenon is related to the level of consciousness. We hypothesized that TTV reduction would be compromised during reduced level of consciousness by propofol anesthetics. We recorded functional magnetic resonance imaging signals of resting-state and stimulus-induced activities in three conditions: wakefulness, sedation, and unconsciousness (i.e., deep anesthesia). We measured the average (trial-to-trial mean, TTM) and variability (TTV) of auditory stimulus-induced activity under the three conditions. We also examined another form of neural variability (temporal variability, TV), which quantifies the overall dynamic range of ongoing neural activity across time, during both the resting-state and the task. We found that (a) TTM deceased gradually from wakefulness through sedation to anesthesia, (b) stimulus-induced TTV reduction normally seen during wakefulness was abolished during both sedation and anesthesia, and (c) TV increased in the task state as compared to resting-state during both wakefulness and sedation, but not anesthesia. Together, our results reveal distinct effects of propofol on the two forms of neural variability (TTV and TV). They imply that the anesthetic disrupts recurrent network dynamics, thus prevents the stabilization of cortical activity states. These findings shed new light on the temporal dynamics of neuronal variability and its alteration during anesthetic-induced unconsciousness.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Disrupted neural variability during propofol‐induced sedation and unconsciousness

Huang

Zhang

et al. 2018

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

show abstract

“…In both regions, we quantified Glx and GABA neurotransmitters, as well as the cerebral spinal fluid (CSF), gray matter (GM) and white matter (WM) content. Also, we computed the regional PLE and the SD, indices of the resting-state temporal structural and variance respectively, as previously described 24,55 (see supplementary methods, supplementary figure 2 and table 1).…”

Section: Mr Sessionmentioning

confidence: 99%

“…22 In the human brain this relationship occurs across a range of timescales and frequencies including infra-slow brain amplitude fluctuations (<0.5 Hz) recorded using functional magnetic resonance imaging (fMRI) during resting wakefulness. 23,24 Recently, we demonstrated that resting-state LRTCs also affect response amplitude to stimuli delivered at a specific phase of spontaneous brain activity (eg, higher LRTC, with larger PLE, amplify response to stimuli delivered at highexcitability phase 24 ). Interestingly, response to multisensory stimuli and multisensory binding are primarily affected by the phase of spontaneous brain activity when stimuli arrive.…”

Section: Introductionmentioning

confidence: 99%

A Neural “Tuning Curve” for Multisensory Experience and Cognitive-Perceptual Schizotypy

Ferri

Nikolova

Perrucci

et al. 2017

Schizophrenia Bulletin

Self Cite

View full text Add to dashboard Cite

Our coherent perception of external events is enabled by the integration of inputs from different senses occurring within a range of temporal offsets known as the temporal binding window (TBW), which varies from person to person. A relatively wide TBW may increase the likelihood that stimuli originating from different environmental events are erroneously integrated and abnormally large TBW has been found in psychiatric disorders characterized by unusual perceptual experiences. Despite strong evidence of inter-individual differences in TBW, both within clinical and nonclinical populations, the neurobiological underpinnings of this variability remain unclear. We adopted an integrated strategy linking TBW to temporal dynamics in functional magnetic resonance imaging (fMRI)-resting-state activity and cortical excitation/inhibition (E/I) balance. E/I balance was indexed by glutamate/Gamma-AminoButyric Acid (GABA) concentrations and common variation in glutamate and GABA genes in a healthy sample. Stronger resting-state longrange temporal correlations, indicated by larger power law exponent (PLE), in the auditory cortex, robustly predicted narrower audio-tactile TBW, which was in turn associated with lower cognitive-perceptual schizotypy. Furthermore, PLE was highest and TBW narrowest for individuals with intermediate levels of E/I balance, with shifts towards either extreme resulting in reduced multisensory temporal precision and increased schizotypy, effectively forming a neural "tuning curve" for multisensory experience and schizophrenia risk. Our findings shed light on the neurobiological underpinnings of multisensory integration and its potentially clinically relevant inter-individual variability.

show abstract

The neuropsychology of consumer behavior and marketing

Shaw

Bagozzi

2017

Consumer Psychology Review

View full text Add to dashboard Cite

Insights and tools from neuroscience are of great value to marketers. Neuroscientific techniques allow consumer researchers to understand the fundamental neural underpinnings of psychological processes that drive consumer behavior, and elucidate the "black box" that is the consumer's mind. In the following review, we provide an overview of the fundamental tenets of consumer neuroscience, selectively outline key areas of marketing that consumer neuroscience has contributed to, compare and contrast neuroscientific tools and methods, and discuss future directions for neurophysiological work in marketing. In doing so, we illustrate the broad substantive landscape that neuroscience can add value to within marketing. K E Y W O R D Sconsumer behavior, consumer neuroscience, decision-making, decision neuroscience, genetic associations, marketing, neuroeconomics, neuromarketing, neurophysiology, neuroscience, social neuroscience | INTRODUCTIONMarketers are plagued with the reality that despite widespread use of self-assessment measures, such as surveys and questionnaires, consumers are unskilled at retrospective introspection (Nisbett & Wilson, 1977). In search of more objective and reliable insights into consumer thought processes, the use of psychophysiological measures to study consumer behavior began with electrodermal responses in the 1920s (Bagozzi, 1991) and pupillary dilation in the 1960s, followed shortly after by eye-tracking and heart rate measures (Wang & Minor, 2008).More recently, technological advances have led marketers to use electroencephalography (EEG) and functional magnetic resonance imaging (fMRI; see Table 1 for an overview of neuroscientific methods; . Such applications of neuroscientific techniques to study consumers' emotions and cognitive responses have spawned the field of consumer neuroscience. Consumer neuroscience, defined as applying "tools and theories from neuroscience to better understand decision making and related processes" (Plassmann, Venkatraman, Huettel, & Yoon, 2015; p. 427), is an interdisciplinary academic subfield of marketing and neuroeconomics, at the intersection of neuroscience and consumer psychology, and overlaps with decision neuroscience. Consumer neuroscience is differentiated from neuromarketing in that the latter involves the practical implementation of to marketers. However, similar behaviors within an individual, and between individuals, may be elicited as a result of highly different underlying psychological processes, many of which are not readily observable using traditional research methods (Adolphs, 2010;Sanfey, Rilling, Aronson, Nystrom, & Cohen, 2003). Thus, neuroimaging techniques are attractive in marketing applications because they provide researchers and practitioners with seemingly objective physiological data, are potentially less susceptible to experimenter bias or demand effects, and can be more reliable than self-report data (Camerer, Loewenstein, & Prelec, 2005).The purpose of this article was to review the foundational tenets of consumer...

show abstract

Is There a Nonadditive Interaction Between Spontaneous and Evoked Activity? Phase-Dependence and Its Relation to the Temporal Structure of Scale-Free Brain Activity

Cited by 97 publications

References 88 publications

Disrupted neural variability during propofol‐induced sedation and unconsciousness

Disrupted neural variability during propofol‐induced sedation and unconsciousness

A Neural “Tuning Curve” for Multisensory Experience and Cognitive-Perceptual Schizotypy

The neuropsychology of consumer behavior and marketing

Contact Info

Product

Resources

About