Is there a physiological intravascular coagulation in obstetrical cases?

Arocha-Piñango, Carmen Luisa; Linares, J.; Cova, Armando; Martínez, P.I. Barrera

doi:10.3109/00016347909154908

Cited by 12 publications

(6 citation statements)

References 21 publications

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“…Despite the fact that the ratio (antigenlactivity) remained within normal limits throughout the obstetric period, the values for the ratio seen in the 3 -6-hour period of labor, during parturition and the first part of puerperium were slightly elevated in comparison with their preceding periods, due principally to a rise in Factor VII1R:Ag in all three instances and also to a drop in Factor VII1:C in the 3-6-hour period of labor and puerperium. These increases in the ratio coincide with increased positivity of the SDPS and FDP tests, as reported by us previously (1,2).…”

Section: Discussionsupporting

confidence: 88%

“…Physiological intravascular coagulation (DIC) in obstetrics has been reported (19, 21, 23), but Arocha-Pinango et al (2) suggested that the positivity of the serial dilution protamine sulphate (SDPS) test and the increase in the fibrin degradation products (FDP) present in a large proportion of normal obstetrical cases are the consequence of activation of the hemostatic mechanism at the uteroplacental level, rather than a physiological DIC.…”

mentioning

confidence: 99%

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Factor VIIIR: Ag/Factor VIII:C and their Ratio in Obstetrical Cases

Caires

Arocha-Piñango

Rodríguez

et al. 1984

Acta Obstet Gynecol Scand

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Factor VIIIR:Ag and Factor VIII:C levels were found to be significantly increased during pregnancy, labor and puerperium, but not to the extent observed by European and American authors. The ratio Factor VIIIR:Ag/Factor VIII:C was elevated only between the third and sixth hour of labor with respect to early labor, and during parturition and early puerperium with respect to late labor. However, this ratio was in the same range as the normal non-pregnant controls, but in the cases of complicated pregnancy, the ratio reached values much higher than the normal. It was concluded that determination of the ratio appears to be of little value in normal cases but may be of use when there are obstetrical complications. Studies are being performed to try to explain the limited rise in Factor VIII:Ag and Factor VIII:C levels observed in our cases.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Factor VIIIR: Ag/Factor VIII:C and their Ratio in Obstetrical Cases

Caires

Arocha-Piñango

Rodríguez

et al. 1984

Acta Obstet Gynecol Scand

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“…However, when molecular markers of the fibrinolysis system (e.g., D-dimer) are used, the fibrinolysis is reportedly elevated during pregnancy [2,8,16,17]. Pregnant women at term possessed higher plasma D-dimer levels than nonpregnant women in this study.…”

Section: Discussionmentioning

confidence: 55%

Correlation between Grade III Placenta and Plasma Antithrombin III Activity in Full Term Pregnancy

Asakura¹,

Ohshita²,

Suzuki³

et al. 2001

Gynecol Obstet Invest

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We evaluated whether the presence of a grade III placenta correlates with blood hypercoagulability in pregnancy between 37 and 39 weeks of gestation. The placenta was graded by ultrasound in 155 healthy full-term women and the plasma levels of antithrombin III (AT III) activity, thrombin-antithrombin complex (TAT) and D-dimer were correlated with each placental grade. AT III activity levels tended to decrease with advancing placental grade from I to III (p < 0.05). D-dimer showed the same tendency while TAT did not. The incidence of reduced AT III activity levels (<70%) in women with a grade III placenta was about twice those in women with a grade II or I placenta, and that of AT III <80% was 3-fold greater. We concluded that the presence of a grade III placenta in full-term pregnancies correlates with blood hypercoagulability.

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“…Coagulation factors are increased during pregnancy, particularly in the last trimester. This is most striking in the case of plasma fibrinogen concentration 1–4 , but is also observed with factors VII and VIII 5 and, to a moderate extent, with factors IX, X and XII 6 . Factors II and V remain unchanged whereas factors XI and XIII even show a decrease 7–9 .…”

Section: Introductionmentioning

confidence: 79%

Coagulation and fibrinolysis in smoking and nonsmoking pregnant women

Mercelina-Rournans

Ubachs

Wersch

1996

BJOG

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Objective To assess the effects of smoking during pregnancy on coagulation and fibrinolysis. Design A cross‐sectional study. Setting A teaching hospital in Heerlen, The Netherlands. Results Parameters of coagulation activation increased significantly with gestational age. The values presented are median values. Prothrombin fragment 1+2 increased from 0.8 to 25 nmol/l in the nonsmoking group of pregnant women and from 1.0 to 1.8 nmol/l in the smoking group. Thrombin‐antithrombin III (TAT) levels increased from 2.2 to 9.9 μg/l in the nonsmoking group and from 3.1 to 8.5 μg/1 in the smoking group. Parameters of fibrinolysis showed a different picture. Plasminogen levels in both groups rose significantly in the first half of gestation reaching a plateau in the second half. The α2‐antiplasmin levels remained constant in both groups, although the smokers started with significantly higher levels: 119 versus 105 % in the nonsmokers. The D‐dimer levels rose significantly in both groups: from 278 to 847 μg/ml in the nonsmokers and from 215 to 520 μg/ml in the smokers. They were significantly lower in the smoking group from the 11th up to the 40th weeks. The D‐dimer/TAT ratio was significantly higher in the nonsmokers. Conclusions In smoking pregnant women the activated coagulation process was not counterbalanced by an adequate increase of fibrinolysis which was the case in the nonsmokers.

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Is there a physiological intravascular coagulation in obstetrical cases?

Cited by 12 publications

References 21 publications

Factor VIIIR: Ag/Factor VIII:C and their Ratio in Obstetrical Cases

Factor VIIIR: Ag/Factor VIII:C and their Ratio in Obstetrical Cases

Correlation between Grade III Placenta and Plasma Antithrombin III Activity in Full Term Pregnancy

Coagulation and fibrinolysis in smoking and nonsmoking pregnant women

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