Is-there a place for vagus nerve stimulation in inflammatory bowel diseases?

Bonaz, Bruno

doi:10.1186/s42234-018-0004-9

Cited by 38 publications

(28 citation statements)

References 72 publications

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“…These supplement traditional market indications for bioelectronic medicines such as pain and overactive bladder . Additional areas of research currently beginning early stage clinical testing include the use of therapeutic electrical stimulation to treat inflammation, metabolism, and endocrine disorders . The increasing prevalence of bioelectronic medicines has led to a renewed interest in both developing novel devices as well as improving the mechanistic understanding of how neural interface technologies interact with the nervous system.…”

Section: Introductionmentioning

confidence: 99%

An Injectable Neural Stimulation Electrode Made from an In‐Body Curing Polymer/Metal Composite

Trevathan

Baumgart

Nicolai

et al. 2019

Adv Healthcare Materials

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Implanted neural stimulation and recording devices hold vast potential to treat a variety of neurological conditions, but the invasiveness, complexity, and cost of the implantation procedure greatly reduce access to an otherwise promising therapeutic approach. To address this need, a novel electrode that begins as an uncured, flowable prepolymer that can be injected around a neuroanatomical target to minimize surgical manipulation is developed. Referred to as the Injectrode, the electrode conforms to target structures forming an electrically conductive interface which is orders of magnitude less stiff than conventional neuromodulation electrodes. To validate the Injectrode, detailed electrochemical and microscopy characterization of its material properties is performed and the feasibility of using it to stimulate the nervous system electrically in rats and swine is validated. The silicone-metal-particle composite performs very similarly to pure wire of the same metal (silver) in all measures, including exhibiting a favorable cathodic charge storage capacity (CSC C ) and charge injection limits compared to the clinical LivaNova stimulation electrode and silver wire electrodes. By virtue of its simplicity, the Injectrode has the potential to be less invasive, more robust, and more cost-effective than traditional electrode designs, which could increase the adoption of neuromodulation therapies for existing and new indications.

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Section: Introductionmentioning

confidence: 99%

An Injectable Neural Stimulation Electrode Made from an In‐Body Curing Polymer/Metal Composite

Trevathan

Baumgart

Nicolai

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…1,2 Additional areas of research currently beginning early stage clinical testing include the use of therapeutic electrical stimulation to treat inflammation, metabolism, and endocrine disorders. [3][4][5][6] The increasing prevalence of Bioelectronic Medicines has led to a renewed interest in both developing novel devices as well as improving the mechanistic understanding of how neural interface technologies interact with the nervous system. This has resulted in numerous large-scale government funding programs such as the White House BRAIN Initiative, the NIH SPARC Program, and the DARPA HAPTIX and ElectRx Programs.…”

Section: Introductionmentioning

confidence: 99%

A Truly Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite

Trevathan

Baumgart

Nicolai

et al. 2019

Preprint

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AbstractImplanted neural stimulation and recording devices hold vast potential to treat a variety of neurological conditions, but the invasiveness, complexity, and cost of the implantation procedure greatly reduce access to an otherwise promising therapeutic approach. To address this need, we have developed a novel electrode that begins as an uncured, flowable pre-polymer that can be injected around a neuroanatomical target to minimize surgical manipulation. Referred to as the Injectrode, the electrode conforms to target structures forming an electrically conductive interface which is orders of magnitude less stiff than conventional neuromodulation electrodes. To validate the Injectrode, we performed detailed electrochemical and microscopy characterization of its material properties and validated the feasibility of using it to electrically stimulate the nervous system in rats and swine. The silicone-metal-particle composite performed very similarly to pure wire of the same metal (silver) in all measures, including exhibiting a favorable cathodic charge storage capacity (CSCC) and charge injection limits compared to the clinical LivaNova stimulation electrode and silver wire electrodes. By virtue of being simpler than traditional electrode designs, less invasive, and more cost-effective, the Injectrode has the potential to increase the adoption of neuromodulation therapies for existing and new indications.

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“…One is the successful use of vagus nerve stimulation (VNS) in the treatment of human inflammatory and autoimmune diseases (Koopman et al, 2016;Meregnani et al, 2011;Pavlov & Tracey, 2017). The current experience with using implanted devicegenerated VNS in a clinical trial with patients with inflammatory bowel disease (Crohn's disease) was summarized by Bonaz (Bonaz, 2018). The author outlines important findings in the context of our improved understanding of the functional anatomy of the vagus nerve, new clinical knowledge of VNS for epilepsy and depression and remaining challenges (Bonaz, 2018).…”

mentioning

confidence: 99%

“…The current experience with using implanted devicegenerated VNS in a clinical trial with patients with inflammatory bowel disease (Crohn's disease) was summarized by Bonaz (Bonaz, 2018). The author outlines important findings in the context of our improved understanding of the functional anatomy of the vagus nerve, new clinical knowledge of VNS for epilepsy and depression and remaining challenges (Bonaz, 2018). These include finding optimal regimens (frequency, pulse width, waive forms, and duration) of chronic VNS, further miniaturization of the devices and targeting specificity.…”

mentioning

confidence: 99%

“…These include finding optimal regimens (frequency, pulse width, waive forms, and duration) of chronic VNS, further miniaturization of the devices and targeting specificity. He also summarizes the pros and cons of invasive (through implanted devices) and non-invasive VNS, including transcutaneous VNS of the auricular branch of the vagus nerve, or the use of devices for cervical vagus nerve stimulation (Lerman et al, 2016) as therapeutic approaches (Bonaz, 2018). Preclinical and clinical research going hand in hand is critical for advancing the field of Bioelectronic Medicine.…”

mentioning

confidence: 99%

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