Is there a relationship between systemic inflammatory markers and abnormal uterine bleeding in unclassifiable cases according to the PALM-COEIN system?

Abstract

The aim of this study is to assess the possibility of subclinical inflammation and the difference of SIR markers in cases with abnormal uterine bleeding (AUB). Materials and Methods: A total of 529 women were enrolled in the study. Patients were classified according to diagnostic categories of PALM-COEIN. The comparisons between the groups were analyzed by one way variant analysis and Kruskal-Wallis analysis. Relations between numerical variables were assessed by Spearman Correlation analysis. Results: No significant difference was found between the groups for SIR markers. When SIR markers were compared between the groups Neutrophil / lymphocyte ratio (NLR) was negatively correlated with lymphocyte/platelet ratio (LPR) in all the groups. Although a strong negative correlation was detected between NLR and lymphocyte/monocyte ratio (LMR) in Groups 2, 3, and 4, no significant relation was detected in Group 1. Conclusions: In this study, no significant difference of SIR markers was observed between AUB cases with functional or structural abnormalities and unclassifiable AUB cases according to PALM-COEIN classification.