Is there a relationship between fracture healing and mean platelet volume?

Serbest, Sancar; Tiftikçi, Uğur; Tosun, Hacı Bayram; Gümüştaş, Seyit Ali; Uludag, Abuzer

doi:10.2147/tcrm.s108790

Cited by 39 publications

(36 citation statements)

References 43 publications

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“…Factors affecting fracture healing and research into the acceleration of healing are popular topics of research. Many different studies have been made on the subject of accelerating fracture healing in particular [ 13 – 16 ].…”

Section: Discussionmentioning

confidence: 99%

The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

et al. 2017

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BackgroundWhether or not there is a relationship between the newly-discovered irisin hormone and bone healing is not yet known. The aim of this study was to investigate what effect irisin hormone has on the bone healing process.Material/MethodsThe study included 21 adult patients with a diagnosed fracture of the lower extremity (femur or tibia). Informed consent was obtained from all the patients. A total of four venous blood samples were taken from the patients: before fracture stabilization, then postoperatively on days 1, 10, and 60. In patients with femoral neck fracture who had hip prosthesis applied, bone tissue samples were taken from the removed femur head and irisin was determined immunohistochemically in muscle biopsies taken from the same patients.ResultsIn analysis, it was revealed that the mean value of irisin 60 days after operation is significantly higher than the values of irisin before operation, 1 day after operation, and 15 day after operation (p<0.001, p<0.001, p<0.001, respectively). Intense staining was observed in compact bone tissue, muscle tissue, and in hypertrophic vascular endothelium within the Havers canal.ConclusionsThe level of irisin hormone increased in the bone union process and affects fracture healing due to irisin receptors in human bone tissue.

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Section: Discussionmentioning

confidence: 99%

The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

et al. 2017

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“…There were two nonunion in medial malleolar fracture cases because of no internal fixation. Many factors were related with the bone healing [12,13]. Our results suggest that internal fixation is more effective for MMF in adolescents.…”

Section: Discussionmentioning

confidence: 60%

Concurrent ipsilateral Tillaux fracture and medial malleolar fracture in adolescents: management and outcome

et al. 2020

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Background The concurrent ipsilateral Tillaux fracture with medial malleolar fracture in adolescents commonly suffer from high-energy injury, making treatment more difficult. The aim of this study was to discuss the mechanism on injury, diagnosis, and treatment of this complex fracture pattern. Methods The charts and radiographs of six patients were reviewed. The function was assessed by the American Orthopedic Foot and Ankle Society ankle-hindfoot scores. Results The mean age at operation was 12.8 years. The mean interval from injury to operation was 7.7 days. Five Tillaux fractures and all medial malleolar fractures were shown on AP plain radiographs. One Tillaux fracture and two cases with avulsion of posterolateral tibial aspect were confirmed in axial computerized tomography. There was talar subluxation laterally with medial space widening in three and syndesmotic disruption in one. There were five patients sustaining ipsilateral distal fibular fractures. All fractures, except nonunion in two medial malleolar fractures and in one Tillaux fracture, healed within 6–8 weeks. There was one case of osteoarthritis of ankle joint. The average AOFAS score was 88.7. Conclusions Computerized tomography is helpful in identifying the fracture pattern. Anatomic reduction and internal fixation of Tillaux and medial malleolar fracture was recommended to restore the articular surface congruity and ankle stability.

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“… 10 Other important factors are mechanical instability due to insufficient osteosynthesis, local avital bone, and individual host factors such as smoking 28 or other abnormalities. 29 Mechanical insufficiency and dead bone have been determined as the most important etiological factors. 10 To address this, radical debridement as the most important therapy against osteomyelitis 30 is the basic principle of our treatment algorithm.…”

Section: Discussionmentioning

confidence: 99%

Initial peri- and postoperative antibiotic treatment of infected nonunions: results from 212 consecutive patients after mean follow-up of 34 months

Helbig¹,

Bechberger²,

Aldeeri³

et al. 2018

TCRM

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PurposeInfected nonunions of the long bones belong to the most feared complications in the field of orthopedic and trauma surgery. Optimal antibiotic therapy should start early with the first revision surgery. Therefore, the aim of this study was to evaluate our peri- and postoperative antibiotic regime in context with the microbial spectrum and antibiotic resistances of patients with infected nonunions and to assess the possible impact on healing rates.MethodsWe included all patients with first revision surgery during 2010–2015 due to nonunion of long bones with a clinical history of infection treated with radical debridement, local application of a gentamicin-impregnated bone cement, and systemic cefuroxime. Mean follow-up was 34.2 months. Data collection was performed retrospectively using a computerized databank with information about microbial species from intraoperatively acquired tissue samples and respective antibiograms. Bone fusion rates were evaluated based on findings of the latest X-rays and computed tomography scans.ResultsTwo hundred and twelve patients with nonunion and history of infection were selected; 171 patients had positive intraoperative microbial evidence of infection. Bacterial testing was mostly positive in fractures of the tibia (47.4%) and the femur (27.5%). Coagulase-negative Staphylococcus spp. were the most frequently detected (44.4%) followed by mixed infections (18.7%) and Staphylococcus aureus (10.5%). Antibiograms revealed that 62.6% of our cases were cefuroxime sensitive; 87.7% were gentamicin sensitive. Only 10.5% showed resistance to both cefuroxime and gentamicin. There was no statistically significant difference of fusion rates between patients with different microbial species or different antibiograms.ConclusionOur data suggest that besides the high variety of different detected species, initial antibiotic treatment with a combination of systemic cefuroxime and local gentamicin-loaded bone cement is effective and in almost 90% the later determined microbial infection was sensitive to this treatment. Therefore, we recommend initial treatment according to this algorithm until specific antibiograms are available from intraoperatively acquired tissue samples.

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Is there a relationship between fracture healing and mean platelet volume?

Cited by 39 publications

References 43 publications

The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

Concurrent ipsilateral Tillaux fracture and medial malleolar fracture in adolescents: management and outcome

Initial peri- and postoperative antibiotic treatment of infected nonunions: results from 212 consecutive patients after mean follow-up of 34 months

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