Is there a relationship between TSH levels and diabetic retinopathy in the Caucasian population?

Nicolau, Joana; Artigas, Carla Francés; Santiago, Ma Angeles Alonso; Manes, Francisco; Simó, Rafael; Comas, Lluís Masmiquel

doi:10.1016/j.diabres.2012.05.015

Cited by 19 publications

(16 citation statements)

References 9 publications

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“…19.6%, P = 0.036). On the contrary, Ramis reported that they could not find any relationship between either TSH levels or the presence of SCH and DR in Caucasian population [32]. Chen [33] reported that patients with type 2 diabetes and SCH were at increased risk of nephropathy and cardiovascular events, but not retinopathy.…”

Section: Discussionmentioning

confidence: 95%

Age at Diagnosis and C-Peptide Level Are Associated with Diabetic Retinopathy in Chinese

et al. 2014

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ObjectiveTo find the associations between diabetic retinopathy and age at diagnosis, C-peptide level and thyroid-stimulating hormone (TSH) level in Chinese type 2 diabetes mellitus.Methods3100 hospitalized type 2 diabetic patients in Peking University People's Hospital were included in this retrospective study. Their medical history and the laboratory data were collected. All the patients received examination of diabetic retinopathy (DR) by professional ophthalmologist.ResultsComparisons among patients with NDR, NPDR and PDR showed that with the progression of diabetic retinopathy, patients turned to have older age but younger age at diagnosis of diabetes, and have higher SBP, longer duration of diabetes, higher mean HbA1c but lower fasting and 2 hours postprandial C-peptide level. Moreover, with the progression of diabetic retinopathy, patients turned to have higher prevalence of primary hypertension, higher prevalence of peripheral vascular sclerosis, higher proportion with insulin treatment. TSH level was comparable among the three groups of patients. Association analysis showed that after adjusting for age, sex, duration of diabetes, body mass index, HbA1c, blood pressure and albuminurea creatinine ratio and insulin treatment, age at diagnosis (OR 0.888, 95%CI 0.870–0.907, p = 0.00) and postprandial C-peptide (OR 0.920, 95%CI 0.859–0.937, p = 0.00) are the independent associated factors of DR in Chinese type 2 diabetes.ConclusionsAccording to the results, postprandial C-peptide level and age at diabetes may be two independent associated factors with DR in Chinese type 2 diabetes. The lower level of postprandial C-peptide, the younger age at diagnosis, may indicate the higher prevalence of DR.

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Section: Discussionmentioning

confidence: 95%

Age at Diagnosis and C-Peptide Level Are Associated with Diabetic Retinopathy in Chinese

et al. 2014

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“…However, in the Chinese study, nephropathy was defined using creatinine and albuminuria grade [14], and the prevalence of diabetic nephropathy was considerably higher (48.6%). tion between SCH and diabetic retinopathy were controversial; 3 of the studies showed an association [12,17], while a study conducted in Spain did not [18]. To the best of our knowledge, no study to date has investigated the association between SCH and diabetic neuropathy.…”

Section: Discussionmentioning

confidence: 98%

Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus

et al. 2014

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“…Previous studies showed that SCH was associated with DR [17,18], while 2 other studies could not find any relationship between SCH and DR [19,20]. Moreover, it was reported that SCH was an independent risk factor for DN [16,20].…”

Section: Discussionmentioning

confidence: 99%

“…Further, 2 reports have shown SCH as a potential factor for increased risk of diabetic retinopathy (DR) [17,18]. However, this relationship between SCH and DR was not found by Ramis et al [19]. Individuals with type 2 diabetes mellitus and SCH were associated with an increased risk of DN, but not with DR [20].…”

Section: Introductionmentioning

confidence: 99%

Association of Thyroid-Stimulating Hormone Levels with Microvascular Complications in Type 2 Diabetes Patients

Zhang

et al. 2017

Med Sci Monit

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BackgroundSubclinical hypothyroidism (SCH) is typically featured by elevated serum concentration of thyroid-stimulating hormone (TSH). This study aimed to determine the relationship between TSH levels and microvascular complications in type 2 diabetes patients.Material/MethodsA total of 860 type 2 diabetes patients were enrolled in this cross-sectional study. Subjects were evaluated for anthropometric measurements, thyroid function, diabetic retinopathy, and diabetic kidney disease. TSH was divided into 3 levels: 0.27–2.49 mU/l, 2.5–4.2 mU/l, and >4.2 mU/l.ResultsAmong the participants, 76 subjects (8.8%) were diagnosed with subclinical hypothyroidism (SCH) (male: 6.6% and female: 11.8%). The prevalence of diabetic retinopathy did not differ among the groups (P=0.259). Of the 860 type 2 diabetic subjects, we further excluded invalid or missing data. Therefore, 800 and 860 subjects were included in our study of diabetic retinopathy (DR) and diabetic kidney disease (DKD), respectively. The frequencies of microalbuminuria and macroalbuminuria differed significantly among the different groups. The frequency of DKD was significantly different among the 3 groups (P=0.001) and was higher in subjects with higher TSH levels. After an adjustment for confounding variables, TSH levels were significantly associated with DKD (P<0.001). When compared with subjects with TSH 0.27–2.49 mU/l, the frequency of DKD was higher in subjects with TSH >4.20 mU/l (OR 1.531, 95% CI 1.174–1.997) and with TSH 2.50–4.20 mU/l (OR 1.579, 95% CI 1.098–2.270). However, TSH levels was not significantly correlated with DR (P=0.126).ConclusionsType 2 diabetic patients with higher TSH values had a higher prevalence of DKD.

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Is there a relationship between TSH levels and diabetic retinopathy in the Caucasian population?

Cited by 19 publications

References 9 publications

Age at Diagnosis and C-Peptide Level Are Associated with Diabetic Retinopathy in Chinese

Age at Diagnosis and C-Peptide Level Are Associated with Diabetic Retinopathy in Chinese

Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus

Association of Thyroid-Stimulating Hormone Levels with Microvascular Complications in Type 2 Diabetes Patients

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