Is there a relationship between clinical severity of psoriasis and histopathological findings? a clinicopathological study

Aslan, Figen

doi:10.17826/cumj.461671

Cited by 1 publication

(1 citation statement)

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“…It has been reported in the literature that there is no correlation between histopathological findings and PASI scores. 33,34 In their quantitative computer-aided study, Kim et al observed a relationship between histopathological findings and the three components of the PASI score (erythema, thickness, and desquamation). 35 In our study, stratum basale necrotic keratinocytes were observed at higher rates only in patients with high PASI values.…”

Section: Dermal Infiltrationmentioning

confidence: 99%

Psoriazis hastalarında klasik/klasik olmayan histopatolojik bulguların psoriasis alt tiplerine, hastalık süresine ve şiddetine, anatomik bölgeye ve klinik görünüme göre değişimi

GÜRSEL ÜRÜN,

KARAKALEM,

CAN

et al. 2024

Acta Medica Nicomedia

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Objective: Although histopathological examination is considered the gold standard in the diagnosis of psoriasis, it has limited usefulness in patients with non-classical histopathological and/or clinical presentations. The aim of this study was to examine the distribution of classical and non-classical histopathological findings according to psoriasis subtype, disease duration, disease severity, biopsy site, and classical/non-classical presentation. Methods: We retrospectively reviewed the records of 160 patients with histopathologically confirmed psoriasis. Classical and non-classical histopathological features were determined according to dermatopathology textbooks and literature. Patients were categorized according to disease duration (≤12 and >12 months) and disease severity (Psoriasis Area Severity Index [PASI] ≤10 and >10) at presentation, and classical/non-classical presentation (based on morphology, distribution, nail pitting, and family history). Results: The most common classical histopathological findings were regular acanthosis (99.4%), confluent parakeratosis (96.3%), blood vessels, dilated (93.1%), hyperkeratosis (89.4%), and suprapapapillary plate thinning (89.4%). The most common non-classical histopathological findings were superficial perivascular dermal infiltration (81.3%) and spongiosis (53.8%). Hyperkeratosis (p=0.044) and intraepidermal lymphocyte accumulation (p=0.042) were more frequent in patients with a disease duration >12 months. The presence of Munro microabscess (p=0.010) and stratum basale necrotic keratinocytes (p=0.031) were observed more frequently in patients with PASI >10. Significant hyperkeratosis (p=0.024) and suprapapillary plate thinning (p=0.027) were more common in trunk biopsies compared to other locations. Spongiosis (p=0.005) and intraepidermal lymphocytes (p=0.008) were more common in patients with non-classical clinical presentation. Conclusion: Non-classical histopathological findings can be observed in patients with psoriasis. Clinical features should be considered when evaluating classical/non-classical histopathological findings during diagnosis.

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Section: Dermal Infiltrationmentioning

confidence: 99%