Is there a Right-hemisphere Dysfunction in Asperger's Syndrome?

Abstract

CORRESPONDENCE change from pre-treatment scores was small, the majority of the patients showing little or no over all improvement. We concluded that although d propranolol has a detectable therapeutic effect on schizophrenic symptomatology, this effect is more of pharmacological interest than of major clinical significance, as the change on rating scales did not compare favourably with the changes observed with conventional neuroleptics in adequate doses. Propranolol has been a subject of research for over a decade, and several studies conclude that it has a statistically significant effect in reducing psychotic symptomatology. Clinicians are far from convinced. A weak antipsychotic effect for pro pranolol is the best that can be concluded from experience so far. It remains to be seen whether or not the propranolol molecule can be modified to produce a more effective antipsychotic agent. The clinical investigator has done his work and this is now a challenge for the pharmaceutical industry.