Is there a role for continuous infusion of β-lactam antibiotics in severe sepsis?

Bates, Angela; Joffe, Ari R.

doi:10.21037/jtd.2016.03.81

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…The answer is far from clear. 31 In a preliminary study in 2013, Dulhunty and colleagues showed that although continuous infusion improved the pharmacokinetics there was no overall effect on ICU survival, albeit there was a statistically significant improvement in clinical cure. 30 More recently, the BLISS trial reached almost identical conclusions.…”

Section: Should Combination Antibiotic Therapy Be Used Routinely In T...mentioning

confidence: 99%

Current Clinical Controversies in the Management of Sepsis

Cohen

2016

Journal of the Royal College of Physicians of Edinburgh

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Sepsis remains a challenging clinical problem requiring prompt diagnosis and optimal clinical management if the continuing high mortality is to be contained. In this brief review I consider four specific questions that are the subject of ongoing controversy. First, whether the new 'Sepsis-3' definitions will be helpful, in particular in improving diagnosis, or whether the rapid move towards precision medicine will make the definition redundant. Second, should we routinely use combinations of antibiotics for the empiric treatment of sepsis. Third, whether there is any clinical benefit in continuous rather than bolus administration of ß-lactam antibiotics. Finally, whether there is good evidence that biomarkers such as procalcitonin can help reduce the duration of antibiotic therapy.

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Section: Should Combination Antibiotic Therapy Be Used Routinely In T...mentioning

confidence: 99%