Is there a role for PRF with simvastatin in stage I osteoradionecrosis?

Baliga, Mohan; Kumari, Thushara; Tusharbhai, Dani Mihir; Sarkar, Souvick

doi:10.1016/j.oraloncology.2018.11.009

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…There is a paucity of high-level evidence data in the therapeutic value of platelet concentrate as surgical adjunct in the management of ORN. Interestingly, PRP/PRF has been used in combination with autologous free fat graft [46], statins [47], and allogenic dental pulp stem cells [48] in the treatment of established ORN with promising results. However, most of the available data promoting the use of platelet concentrates in ORN are obtained from case-reports with relatively low-level of evidence [46][47][48][49][50].…”

Section: Discussionmentioning

confidence: 99%

Autologous Platelet-Rich Fibrin (PRF) as an Adjunct in the Management of Osteoradionecrosis and Medication-Related Osteonecrosis of Jaws. Case Series in A Single Centre

et al. 2021

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Osteoradionecrosis (ORN) of the jaws and medication-related osteonecrosis of the jaws (MRONJ) are uncommon but serious diseases affecting the oral and maxillofacial region with clinically similar appearance but distinct pathophysiology. Management of ORN and MRONJ is inherently challenging and the treatment outcomes are unpredictable. The use of autologous platelet concentrates (APCs) to promote hard and soft tissue healing is well described in the literature, and the efficacy of leucocyte and platelet-rich fibrin (L-PRF) has been well documented in a number of clinical studies. The aim of this study was to present our treatment strategy and the outcomes of incorporating L-PRF as a surgical adjunct in management of ORN and MRONJ in our centre. Methods: eight cases of ORN and MRONJ were treated with a combination of sequestrectomy and L-PRF as a surgical adjunct. Results: the overall success was 87.5%. Using L-PRF as an adjunct, we were able to predictably manage ORN and MRONJ without causing significant morbidity. Conclusion: our experience shows that L-PRF may be used as a valuable and cost-effective adjunct to surgical management of ORN and MRONJ. However, due to a limited number of patients, and a short period of review, the true effectiveness of the method is yet to be demonstrated in a longer follow-up study including a greater number of patients, besides the inclusion of a control group.

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Section: Discussionmentioning

confidence: 99%

Autologous Platelet-Rich Fibrin (PRF) as an Adjunct in the Management of Osteoradionecrosis and Medication-Related Osteonecrosis of Jaws. Case Series in A Single Centre

et al. 2021

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“…On one hand, there are some promising case reports on the ORN treatment performed with platelet concentrates: 1) plasma rich in growth factors ( 9 ), 2) combination of platelet-rich plasma (PRP), alloplastic graft, and allogeneic dental pulp stem cells ( 12 ), 3) PRP gel ( 13 ), 4) platelet gel ( 14 ), and 5) combination of simvastatin and platelet-rich fibrin ( 15 ). On the other hand, a double-blind, split-mouth, randomized clinical trial showed that PRP was not effective in preventing ORN following tooth extraction pre-RT ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Leukocyte- and platelet-rich fibrin does not provide any additional benefit for tooth extraction in head and neck cancer patients post-radiotherapy: a randomized clinical trial

Palma¹,

Marcucci²,

Remondes³

2020

Med Oral

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Background One of the most important complications of radiotherapy (RT) for head and neck cancer (HNC) is osteoradionecrosis (ORN) of the jaws, arising mainly from tooth extractions. Thus, the present study aimed to evaluate the efficacy of leukocyte- and platelet-rich fibrin (L-PRF) in preventing ORN following tooth extraction in post-irradiated HNC patients, as well as other postoperative complications. Material and Methods 23 patients previously submitted to conventionally fractionated 3D-conformational RT for HNC underwent atraumatic tooth extractions with perioperative antibiotic therapy. Besides, they were randomly assigned to receive L-PRF clots to fill and cover the extraction sockets (n=11, Test Group) or not (n=12, Control Group). A visual analog scale was used to quantify postoperative pain on the 3rd and 7th days. For ORN diagnosis, patients were clinically assessed for up to 180 days. Other postoperative complications (edema, alveolitis, suture dehiscence, continuous bleeding, and oroantral communication) were also evaluated within this period. Results No case of ORN or another surgical complication was observed and there were no differences in the postoperative pain scores between the groups on the 3rd and 7th days. Conclusions L-PRF did not seem to provide any additional benefits than those achieved by the combination of the surgical and drug protocols used for tooth extractions in the post-irradiated HNC patients. Key words: Radiotherapy, osteoradionecrosis, tooth extraction, head and neck cancer.

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Autologous platelet concentrates in extraction sockets for the prevention of osteoradionecrosis: a systematic review of controlled clinical trials

Serrano

Gomes

Silva

et al. 2022

Oral Maxillofac Surg

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Is there a role for PRF with simvastatin in stage I osteoradionecrosis?

Cited by 6 publications

References 6 publications

Autologous Platelet-Rich Fibrin (PRF) as an Adjunct in the Management of Osteoradionecrosis and Medication-Related Osteonecrosis of Jaws. Case Series in A Single Centre

Autologous Platelet-Rich Fibrin (PRF) as an Adjunct in the Management of Osteoradionecrosis and Medication-Related Osteonecrosis of Jaws. Case Series in A Single Centre

Leukocyte- and platelet-rich fibrin does not provide any additional benefit for tooth extraction in head and neck cancer patients post-radiotherapy: a randomized clinical trial

Autologous platelet concentrates in extraction sockets for the prevention of osteoradionecrosis: a systematic review of controlled clinical trials

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