“…However, we do believe that only through the collaboration among expert practitioners expert in different fields will it be possible to achieve a correct diagnosis of these tissues. Overall, these manuscripts confirmed the efficacy of the use of FC for the diagnosis of these diseases, and provide objective, quantitative and rapid results for the evaluation of solid tissues suspected for lymphoma or other tumors . …”
supporting
confidence: 59%
“…This issue of Cytometry includes four papers dealing with the utility of flow cytometry (FC) immunophenotyping, together with fine‐needle aspiration cytology (FNAC) or standard core biopsy in the diagnosis of extra‐hematological tissues obtained from patients with different types of malignancies. These include thyroid lymphomas, breast implant‐ associated anaplastic large‐cell lymphomas, intracranial meningiomas, and brain tumors . FC studies are considered as a very useful tool for the diagnosis and classification of T, B and NK‐cell lymphoid neoplasms, as well as of myeloid malignancies .…”
“…However, we do believe that only through the collaboration among expert practitioners expert in different fields will it be possible to achieve a correct diagnosis of these tissues. Overall, these manuscripts confirmed the efficacy of the use of FC for the diagnosis of these diseases, and provide objective, quantitative and rapid results for the evaluation of solid tissues suspected for lymphoma or other tumors . …”
supporting
confidence: 59%
“…This issue of Cytometry includes four papers dealing with the utility of flow cytometry (FC) immunophenotyping, together with fine‐needle aspiration cytology (FNAC) or standard core biopsy in the diagnosis of extra‐hematological tissues obtained from patients with different types of malignancies. These include thyroid lymphomas, breast implant‐ associated anaplastic large‐cell lymphomas, intracranial meningiomas, and brain tumors . FC studies are considered as a very useful tool for the diagnosis and classification of T, B and NK‐cell lymphoid neoplasms, as well as of myeloid malignancies .…”
“…In the clinical arena, iFC has proven invaluable in surgeries from less malignant meningiomas [60] to aggressive brain tumors, like glioblastomas, where distinguishing tumor margins can be particularly challenging [61]. By offering near-real-time feedback, surgeons can ensure they remove as much of the tumor as possible while minimizing damage to healthy tissue.…”
Brain malignancies, given their intricate nature and location, present significant challenges in both diagnosis and treatment. This review critically assesses a range of diagnostic and surgical techniques that have emerged as transformative tools in brain malignancy management. Fast biopsy techniques, prioritizing rapid and minimally invasive tissue sampling, have revolutionized initial diagnostic stages. Intraoperative flow cytometry (iFC) offers real-time cellular analysis during surgeries, ensuring optimal tumor resection. The advent of intraoperative MRI (iMRI) has seamlessly integrated imaging into surgical procedures, providing dynamic feedback and preserving critical brain structures. Additionally, 5-aminolevulinic acid (5-ALA) has enhanced surgical precision by inducing fluorescence in tumor cells, aiding in their complete resection. Several other techniques have been developed in recent years, including intraoperative mass spectrometry methodologies. While each technique boasts unique strengths, they also present potential limitations. As technology and research continue to evolve, these methods are set to undergo further refinement. Collaborative global efforts will be pivotal in driving these advancements, promising a future of improved patient outcomes in brain malignancy management.
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