Is there a role for <scp>IGF</scp>‐1 in the development of second primary cancers?

Shanmugalingam, Thurkaa; Bosco, Cecilia; Ridley, Anne J.; Hemelrijck, Mieke Van

doi:10.1002/cam4.871

Cited by 62 publications

(45 citation statements)

References 129 publications

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“…[ 18 – 20 ] Furthermore, the use of quantitative PCR, permits a highly sensitive quantification of IGF-1 expression, to investigate the correlation between this gene expression in the serum of breast cancer patients and susceptibility to tumor recurrence; however, there are controversies in the studies involving clinical features of breast cancer and the expression levels of IGF-1. [ 21 – 24 ]…”

Section: Introductionmentioning

confidence: 99%

Assessment of IGF-1 expression in the peripheral blood of women with recurrent breast cancer

et al. 2020

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Breast cancer is the most common malignancy affecting women worldwide. The insulin-like growth factor 1 (IGF-1) gene encodes a protein responsible for a wide variety of physiological processes, including differentiation and cell proliferation. Despite several studies on tumor tissues, no study has evaluated IGF-1 expression in the peripheral blood of women with recurrent breast cancer. In this cross-sectional study, IGF-1 expression in the peripheral blood of 146 women with breast cancer treated approximately 5 years ago was quantified by quantitative reverse transcription polymerase chain. The women were divided into 2 groups: non-recurrence (n = 85) and recurrence (n = 61). Statistical analysis of the data was performed using ANOVA, Mann–Whitney, and Chi-squared tests ( P < .05). The results showed no significant difference in IGF-1 expression between the non-recurrence and recurrence groups ( P = .988). In the subgroups of patients with lymph node involvement, no statistically significant difference was observed in IGF-1 expression between women with recurrence and those non-recurrence ( P = .113). In patients without lymph node metastases, IGF-1 messenger ribonucleic acid (mRNA) expression levels were significantly higher in the non-recurrence group than in the recurrence group ( P = .019). Furthermore, using the median IGF-1 mRNA expression as the cutoff point, it was obtained a statistically significant difference in tumor histological grade among women with recurrent breast cancer ( P = .042). These data showed significantly higher IGF-1 expression in women without lymph node metastases in the non-recurrence group compared with the recurrence group. In addition, a significant difference was observed in median IGF-1 mRNA expression in relation to tumor histological grade in women with recurrent breast cancer.

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Section: Introductionmentioning

confidence: 99%

Assessment of IGF-1 expression in the peripheral blood of women with recurrent breast cancer

et al. 2020

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“…There is accumulating evidence derived from systematic meta-analyses that raised serum IGF-1 levels are associated with increased risk of PCa [ 153 – 157 ]. At present, epidemiologists focus on the role of milk-induced IGF-1 signaling in PCa and have demonstrated a relationship between milk consumption, increased serum IGF-1 levels and increased risk of PCa [ 130 ].…”

Section: Introductionmentioning

confidence: 99%

Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer

Melnik

2017

Nutr Metab (Lond)

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There is accumulating evidence that milk shapes the postnatal metabolic environment of the newborn infant. Based on translational research, this perspective article provides a novel mechanistic link between milk intake and milk miRNA-regulated gene expression of the transcription factor p53 and DNA methyltransferase 1 (DNMT1), two guardians of the human genome, that control transcriptional activity, cell survival, and apoptosis. Major miRNAs of milk, especially miRNA-125b, directly target TP53 and complex p53-dependent gene regulatory networks. TP53 regulates the expression of key genes involved in cell homeostasis such as FOXO1, PTEN, SESN1, SESN2, AR, IGF1R, BAK1, BIRC5, and TNFSF10. Nuclear interaction of p53 with DNMT1 controls gene silencing. The most abundant miRNA of milk and milk fat, miRNA-148a, directly targets DNMT1. Reduced DNMT1 expression further attenuates the activity of histone deacetylase 1 (HDAC1) involved in the regulation of chromatin structure and access to transcription. The presented milk-mediated miRNA-p53-DNMT1 pathway exemplified at the promoter regulation of survivin (BIRC5) provides a novel explanation for the epidemiological association between milk consumption and acne vulgaris and prostate cancer. Notably, p53- and DNMT1-targeting miRNAs of bovine and human milk survive pasteurization and share identical seed sequences, which theoretically allows the interaction of bovine miRNAs with the human genome. Persistent intake of milk-derived miRNAs that attenuate p53- and DNMT1 signaling of the human milk consumer may thus present an overlooked risk factor promoting acne vulgaris, prostate cancer, and other p53/DNMT1-related Western diseases. Therefore, bioactive miRNAs of commercial milk should be eliminated from the human food chain.

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“…Since many of these outcomes have also been associated with alterations in circulating insulin-like growth factor-1 (IGF-1), several studies have suggested a possible interaction between vitamin D and IGF-1 [4,5,6]. IGF-1 possesses key roles in regulating cellular proliferation and apoptosis as well as energy metabolism, body size, and organ-specific functions [7,8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial

et al. 2017

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Increasing evidence suggests a possible interaction between vitamin D and insulin-like growth factor-1 (IGF-1). We aimed to investigate effects of vitamin D supplementation on IGF-1 (primary outcome) and calcitriol (1,25(OH)2D) concentrations (secondary outcome). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial—a single-center, double-blind, randomized, placebo-controlled trial (RCT) conducted from 2011 to 2014 at the Medical University of Graz, Austria. Two-hundred subjects with arterial hypertension and 25(OH)D concentrations <30 ng/mL were randomized to either receive 2800 IU of vitamin D daily or placebo for eight weeks. A total of 175 participants (mean ± standard deviation age, 60 ± 11 years; 49% women) with available IGF-1 concentrations were included in the present analysis. At baseline, IGF-1 concentrations were significantly correlated with 1,25(OH)2D (r = 0.21; p = 0.005) but not with 25(OH)D (r = −0.008; p = 0.91). In the RCT, vitamin D had no significant effect on IGF-1 (mean treatment effect 3.1; 95% confidence interval −5.6 to 11.9 ng/mL; p = 0.48), but it increased 1,25(OH)2D concentrations (mean treatment effect 9.2; 95% confidence interval 4.4 to 13.9 pg/mL; p ≤ 0.001). In this RCT, in hypertensive patients with low 25(OH)D concentrations, there was no significant effect of vitamin D supplementation on IGF-1 concentrations. However, we observed a cross-sectional correlation between 1,25(OH)2D and IGF-1 and an increase of 1,25(OH)2D after vitamin D supplementation.

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Is there a role for IGF‐1 in the development of second primary cancers?

Cited by 62 publications

References 129 publications

Assessment of IGF-1 expression in the peripheral blood of women with recurrent breast cancer

Assessment of IGF-1 expression in the peripheral blood of women with recurrent breast cancer

Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer

Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial

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