Pathology of the proximal long head of the biceps can result from multiple etiologies and is often associated with persistent anterior shoulder pain and functional limitations. Biceps tenodesis presents a frequently used treatment option for pathology of the long head of the biceps tendon and can be performed both as by intraarticular or extra-articular technique. Postoperative rehabilitation is often prolonged and can be undesirable in the high-demand professional or athlete. The ability to accelerate postoperative mobilization is limited by the strength of the initial fixation and gap formation from loading of the tenodesed tendon. A new technique is described that uses a combined endobutton and interference screw fixation in a humeral bone tunnel to optimize the strength of initial tendon fixation and minimizes gap formation. In addition, a unique tensioning technique helps to optimize restoration of muscle length, myotension, and cosmesis of the proximal biceps. This novel technique provides a safe, minimally invasive fixation of the long head of the biceps and may help to accelerate return to demanding professional and athletic activities.