Is there a “safe” suction pressure in the venous line of extracorporeal circulation system?

Ganushchak, Yuri M.; Korver, Erik

doi:10.1177/0267659120936453

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…The use of PVC tubes reduces the transferability of human blood vessels, which are more resilient. The use of water impacts the cavitation formation in the in vitro circuit because blood contains many gas nuclei, making cavitation appearance easier 25 . This study had no pulsating elements integrated into the in vitro setup.…”

Section: Discussionmentioning

confidence: 99%

“…The use of water impacts the cavitation formation in the in vitro circuit because blood contains many gas nuclei, making cavitation appearance easier. 25 This study had no pulsating elements integrated into the in vitro setup. Therefore, it is unknown whether the results obtained in this study potentially can be affected by pulsating elements and hence cyclic changes in pre-and afterload.…”

Section: Study Limitationsmentioning

confidence: 99%

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Vibrational characterization of cavitation in left ventricular assist device

et al. 2023

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BackgroundThe left ventricular assist device (LVAD) is a mechanical circulatory support device for patients with severe heart failure. Microbubbles caused by cavitation in the LVAD can potentially lead to physiological and pump‐related complications. The aim of this study is to characterize the vibrational patterns in the LVAD during cavitation.MethodsThe LVAD was integrated into an in vitro circuit and mounted with a high‐frequency accelerometer. Accelerometry signals were acquired with different relative pump inlet pressures ranging from baseline (+20 mmHg) to −600 mmHg in order to induce cavitation. Microbubbles were monitored with dedicated sensors at the pump inlet and outlet to quantify the degree of cavitation. Acceleration signals were analyzed in the frequency domain to identify changes in the frequency patterns when cavitation occurred.ResultsSignificant cavitation occurred at the low inlet pressure (−600 mmHg) and was detected in the frequency range between 1800 and 9000 Hz. Minor degrees of cavitation at higher inlet pressures (−300 to −500 mmHg) were detected in the frequency range between 500–700, 1600–1700 Hz, and around 12 000 Hz. The signal power of the dominating frequency ranges was statistically significantly different from baseline signals.ConclusionVibrational measurements in the LVAD can be used to detect cavitation. A significant degree of cavitation could be detected in a wide frequency range, while minor cavitation activity could only be detected in more narrow frequency ranges. Continuous vibrational LVAD monitoring can potentially be used to detect cavitation and minimize the damaging effect associated with cavitation.

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Section: Discussionmentioning

confidence: 99%

Section: Study Limitationsmentioning

confidence: 99%

Vibrational characterization of cavitation in left ventricular assist device

et al. 2023

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Allgemeine Grundlagen

Räpple

2022

Ecmo

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Exploring the Nexus: Gaseous Micro-embolic Activity and Pressure Drop on ALONE ECMO Oxygenator

Condello

2024

Biomedical Materials & Devices

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The role of inlet and outlet oxygenator pressure know as pressure drop (ΔP) in the elimination of the gaseous micro-emboli activity (GMEA) remains obscured during Extracorporeal Membrane Oxygenation (ECMO) and Minimally Invasive Extracorporeal Circulation (MiECC). There is conflicting literature on the role of pressure drop in oxygenators as well as on oxygenating performance, fluid dynamics and in the role of gaseous micro-embolic activity elimination. We analyzed 14 procedures, 10 MiECC with polypropylene fibers ALONE AF oxygenator and 4 ECMO with polymethylpentene Alone ECMO Oxygenator (Eurosets, SRL, Medolla,Italy), in the central and peripheral cannulation configuration, respectively, through the use of GAMPT BCC300 for air gas micro-emboli (GME) in relation to the ΔP of Oxygenator and incidence of cavitation. The groups of MiECC, Central Cannulation VS Peripheral Cannulation reported: mean values for cavitation n° of bubbles was 330 ± 12 vs 80 ± 13; 1.5 vs 0% reported a diameter > 500 μm; GME volume was 1.51 ± 0.2 vs 0.121 ± 0.2 (μL) in the arterial line, the mean ΔP of oxygenator reported was 89 ± 11 vs 130 ± 29 mmHg. The groups of ECMO, Central Cannulation VS Peripheral Cannulation reported: mean values for cavitation n° of bubbles was 470 ± 12 vs 140 ± 17; 2.1 vs 0% reported a diameter > 500 μm; GME volume was 2.5 ± 0.5 vs 0.355 ± 0.7 (μL) in the arterial line, the mean ΔP of oxygenator reported was 88 ± 15vs 150 ± 23 mmHg. In this report, patients with low pressure drop in the oxygenator reported a statistically significant increase in GMEA in the arterial line of the circuit for each cavitation phenomenon, compared to the group with high pressure drop in the oxygenator who reported a reduced GMEA. In this report, oxygenators with higher pressure drops demonstrated a significant reduction of GMEA, however, further studies are needed to confirm these results.

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Is there a “safe” suction pressure in the venous line of extracorporeal circulation system?

Cited by 4 publications

References 32 publications

Vibrational characterization of cavitation in left ventricular assist device

Vibrational characterization of cavitation in left ventricular assist device

Allgemeine Grundlagen

Exploring the Nexus: Gaseous Micro-embolic Activity and Pressure Drop on ALONE ECMO Oxygenator

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