Is there an association between the plasma levels of uremic toxins from gut microbiota and anemia in patients on hemodialysis?

Capo-Chichi, Jean C C; Borges, Natália Alvarenga; Reis, Drielly Cristhiny Mendes de Vargas; Nakao, Lia S.; Mafra, Denise

doi:10.1007/s11255-021-03001-7

Int Urol Nephrol

2021

DOI: 10.1007/s11255-021-03001-7

|View full text |Cite

Is there an association between the plasma levels of uremic toxins from gut microbiota and anemia in patients on hemodialysis?

Jean C C Capo-Chichi

Natália Alvarenga Borges

Drielly Cristhiny Mendes de Vargas Reis

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Role of the Gut Microbiota in Complications among Hemodialysis Patients

Du,

Zhao,

Ding

et al. 2024

Microorganisms

View full text Add to dashboard Cite

The composition of the gut microbiota varies among end-stage renal disease (ESRD) patients on the basis of their mode of renal replacement therapy (RRT), with notably more pronounced dysbiosis occurring in those undergoing hemodialysis (HD). Interventions such as dialysis catheters, unstable hemodynamics, strict dietary restrictions, and pharmacotherapy significantly alter the intestinal microenvironment, thus disrupting the gut microbiota composition in HD patients. The gut microbiota may influence HD-related complications, including cardiovascular disease (CVD), infections, anemia, and malnutrition, through mechanisms such as bacterial translocation, immune regulation, and the production of gut microbial metabolites, thereby affecting both the quality of life and the prognosis of patients. This review focuses on alterations in the gut microbiota and its metabolites in HD patients. Additionally, understanding the impact of the gut microbiota on the complications of HD could provide insights into the development of novel treatment strategies to prevent or alleviate complications in HD patients.

show abstract

The Role of the Gut Microbiota in Complications among Hemodialysis Patients

Du,

Zhao,

Ding

et al. 2024

Microorganisms

View full text Add to dashboard Cite

show abstract

Gut Dysbiosis and Its Role in the Anemia of Chronic Kidney Disease

Coll,

Cigarran,

Portolés

et al. 2024

Toxins

View full text Add to dashboard Cite

The gut dysbiosis present in chronic kidney disease (CKD) has been associated with anemia. Factors such as the accumulation of gut-derived uremic toxins, increased gut barrier permeability-induced inflammation, and a reduced intestinal production of short-chain fatty acids (SCFAs), all associated with changes in the intestinal microbiota composition in CKD, may lead to the development or worsening of anemia in renal patients. Understanding and addressing these mechanisms related to gut dysbiosis in CKD patients can help to delay the development of anemia and improve its control in this population. One approach is to avoid or reduce the use of drugs linked to gut dysbiosis in CKD, such as phosphate binders, oral iron supplementation, antibiotics, and others, unless they are indispensable. Another approach involves introducing dietary changes that promote a healthier microbiota and/or using prebiotics, probiotics, or symbiotics to improve gut dysbiosis in this setting. These measures can increase the presence of SCFA-producing saccharolytic bacteria and reduce proteolytic bacteria, thereby lowering the production of gut-derived uremic toxins and inflammation. By ameliorating CKD-related gut dysbiosis, these strategies can also improve the control of renal anemia and enhance the responsiveness to erythropoiesis-stimulating agents (ESAs) in ESA-resistant patients. In this review, we have explored the relationship between gut dysbiosis in CKD and renal anemia and propose feasible solutions, both those already known and potential future treatments.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Is there an association between the plasma levels of uremic toxins from gut microbiota and anemia in patients on hemodialysis?

Cited by 2 publications

References 40 publications

The Role of the Gut Microbiota in Complications among Hemodialysis Patients

The Role of the Gut Microbiota in Complications among Hemodialysis Patients

Gut Dysbiosis and Its Role in the Anemia of Chronic Kidney Disease

Contact Info

Product

Resources

About