Is There an Association Between Duration of Untreated Psychosis and 24-Month Clinical Outcome in a First-Admission Series?

Craig, Thomas J.; Bromet, Evelyn J.; Fennig, Shmuel; Tanenberg-Karant, Marsha; Lavelle, Janet; Galambos, Nora

doi:10.1176/ajp.157.1.60

Cited by 213 publications

(204 citation statements)

References 24 publications

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“…A recent epidemiological survey conducted in the same geographical region as our study failed to find an association between duration of untreated illness and 24-month illness outcome (52). Another independent study of neuroleptic-naive patients with DSM-IV schizophrenia showed no relationship between untreated illness duration and quality of life, symptom severity, or remission 6 months after the patients' initial hospitalization (51).…”

Section: Discussioncontrasting

confidence: 72%

Lack of Association Between Duration of Untreated Illness and Severity of Cognitive and Structural Brain Deficits at the First Episode of Schizophrenia

Hoff¹,

Sakuma²,

Razi³

et al. 2000

AJP

107

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Section: Discussioncontrasting

confidence: 72%

Lack of Association Between Duration of Untreated Illness and Severity of Cognitive and Structural Brain Deficits at the First Episode of Schizophrenia

Hoff¹,

Sakuma²,

Razi³

et al. 2000

AJP

107

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“…A total of 402 papers were identified by the search strategy, from which we identified 28 non-overlapping first episode studies that met inclusion criteria (see Appendix 1) (Montague et al, 1989;Barnes et al, 2000;Craig et al, 2000;de Haan et al, 2000;Drake et al, 2000;Ho et al, 2000;Larsen et al, 2000;Black et al, 2001;Verdoux et al, 2001;Cullberg et al, 2002;Malla et al, 2003;Addington et al, 2004;Sim et al, 2004;Chen et al, 2005;Harris et al, 2005;Manchanda et al, 2005;Melle et al, 2005;Oosthuizen et al, 2005;Petersen et al, 2005;Wade et al, 2005;Clarke et al, 2006;Ucok et al, 2006;Wunderink et al, 2006;Crespo-Facorro et al, 2007;Malla et al, 2007;Vyas et al, 2007;Gorna et al, 2008;Yamazawa et al, 2008). The selected studies included a total of 3998 participants.…”

Section: Studies and Patientsmentioning

confidence: 99%

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Boonstra

Klaassen

Sytema

et al. 2012

Schizophrenia Research

211

134

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Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Background: Longer duration of untreated psychosis (DUP) is associated with poorer outcome in terms of positive symptoms, relapse rate, and time to remission. In contrast, the association with negative symptoms is less consistent. Aims: The study had three aims. First, to arrive at a more precise estimate of the correlation between DUP and negative symptoms than previous reviews, by substantially increasing the amount of available data. Second, to see whether the strength of this correlation attenuated over longer follow-up intervals. Third, to determine whether there is a relationship between DUP and changes in negative symptoms. Method: Relevant databases were searched for studies published between December 1992 and March 2009 that reported data on DUP and negative symptoms. We obtained individual patient data where possible and calculated summary correlations between DUP and negative symptoms for each study at baseline, short and long-term follow-up. We used multilevel regression analysis to examine whether the effect of DUP on negative symptoms was the greatest in the early stages of illness. Results: We included 28 non-overlapping studies from the 402 papers detected by the search strategy. After contacting the authors we obtained individual patient data from 16 of these studies involving 3339 participants. The mean DUP was 61.4 weeks (SD = 132.7, median DUP = 12.0). Shorter DUP was significantly associated with less severe negative symptoms at baseline and also at short (1-2 years) and longer term follow-up (5-8 years) (r = 0.117, 0.180 and 0.202 respectively, p b 0.001). The relationship between improvement in negative symptoms and DUP was found to be non-linear: people with a DUP shorter than 9 months showed substantially greater negative symptom reduction than those with a DUP of greater than 9 months. Conclusions: Shorter DUP is associated with less severe negative symptoms at short and long-term follow up, especially when the DUP is less than 9 months. Since there is no effective treatment for negative symptoms, reducing DUP to less than 9 months may be the best way to ameliorate them.

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“…The interval elapsing between the first symptom and the first psychiatric contact defined the DUP. 15 The Positive and Negative Syndrome Scales (PANSS) 16 were administered to the patients. DTI voxelwise statistics were performed by use of a permutation-based inference tool for nonparametric statistical thresholding.…”

Section: Clinical Assessmentmentioning

confidence: 99%

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Filippi

Canu

Gasparotti

et al. 2013

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Previous studies have suggested that structural changes do occur in the brain of patients with schizophrenia compared with healthy control participants. However, findings from such studies are inconclusive, probably because of the different methodologic approaches, the clinical heterogeneity of patient samples, and also the fact that patients enrolled were treated with antipsychotic drugs. The aim of this study was to investigate brain GM volumes and intrinsic structural WM changes in first-contact, antipsychotic drug-naïve patients with schizophrenia.

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Is There an Association Between Duration of Untreated Psychosis and 24-Month Clinical Outcome in a First-Admission Series?

Abstract: Although these findings require replication in other epidemiologically based first-admission samples, at face value they do not support the suggestion of a psychotoxic effect of prolonged exposure to untreated psychosis.

Cited by 213 publications

References 24 publications

Lack of Association Between Duration of Untreated Illness and Severity of Cognitive and Structural Brain Deficits at the First Episode of Schizophrenia

Lack of Association Between Duration of Untreated Illness and Severity of Cognitive and Structural Brain Deficits at the First Episode of Schizophrenia

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

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