Is There An Effect of Inhaled Steroid Treatment  on Heart Rate?

Özkars, Mehmet Yaşar; Argun, Mustafa

doi:10.21911/aai.414

Cited by 1 publication

(12 citation statements)

References 10 publications

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“…Regarding the R‐R interval, 4 of the 6 studies that included this variable 5,6,12,13 found lower values in the asthma group; only Rezvan et al 16 and Tokuyama et al 27 found higher values in the asthma group. In addition, 2 of the 4 studies found 5,12 demonstrated lower SDNN values in the asthma group. Regarding RMSSD, 5 of 6 studies 3,6,12,14,25 found higher values in the asthma group; only Rimes et al 26 found a lower value in the asthma group.…”

Section: Resultsmentioning

confidence: 97%

“…Regarding the methodological quality of the included studies, 5 4,5,14,16,24 were classified as high quality and 10 3,6,12,13,15,25–29 as moderate quality. Table 5 presents the topics assessed in the AHRQ scale.…”

Section: Resultsmentioning

confidence: 99%

“…The full texts of 16 studies were assessed for eligibility, of which 1 was excluded for not presenting resting HRV data. Therefore, 15 studies [3][4][5][6][12][13][14][15][16][24][25][26][27][28][29] were included in this review, of which 12 [3][4][5][6][12][13][14][15]25,26,28,29 were included in the meta-analysis.…”

Section: Study Selectionmentioning

confidence: 99%

“…11 Recent HRV studies have demonstrated greater autonomic dysfunction in children and adolescents with asthma than their healthy peers. [3][4][5][6]12,13 In addition to the standard measurement at rest, measuring HRV in response to exercise may be another way of assessing ANS function in patients with asthma. [14][15][16] During physical activity, parasympathetic activity decreases (vagal withdrawal) and sympathetic activity increases.…”

Section: Introductionmentioning

confidence: 99%

“…5,12,13,29 used long-term measurements (24 h). Regarding HRV software, 4 studies4,14,16,24 used Kubios HRV.…”

mentioning

confidence: 99%

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Impact of asthma on heart rate variability in children and adolescents: Systematic review and meta‐analysis

Schiwe

Vendrusculo

Becker

et al. 2023

Pediatric Pulmonology

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Purpose: Asthma is associated with abnormal autonomic function, and heart rate variability is considered a simple, accurate, and noninvasive tool for monitoring the autonomic system. Thus, the aim of this study was to investigate the impact of asthma on heart rate variability in children and adolescents.Methods: This systematic review of observational studies and clinical trials evaluated heart rate variability in children and adolescents with asthma compared to healthy controls. The data were extracted independently by two reviewers. The quality of the selected articles was assessed using Agency for Health Care Research and Quality indicators. Random effects meta-analysis was performed for each outcome, with the effect size reported as standardized mean difference.Results: Fifteen studies were included, of which five were classified as having high methodological quality. In the meta-analysis, long-term recording of the standard deviation of all normal-to-normal sinus R-R intervals differed significantly between groups (standardized mean difference [SMD] = −0.46 [95% confidence interval {CI}: −0.79 to −0.14], p < 0.005, I 2 = 0%). Moreover, R-R intervals (long-term) were significantly shorter in asthmatic children than controls (SMD = −0.47 [95% CI: −0.68 to −0.25], p < 0.0001, I 2 = 0). There were no significant differences between adjacent normal R-R intervals that exceed 50 ms (long-term) and the root mean square of successive differences between normal sinus R-R intervals (short-term). Regarding frequency-domain variables, long-term low frequency measurements differed significantly between groups (SMD = −0.34 [95% CI: −0.58 to −0.10], p < 0.005, I 2 = 15%). There were no differences in high frequency measurements or in the ratio between low/high frequency powers (short-or long-term) between groups. Conclusion:The results confirm the impact of asthma on heart rate variability in children and adolescents, indicating lower heart rate variability and sympathetic modulation.

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