Is there an effect of dietary intake on MS-related fatigue? – A systematic literature review

Pommerich, Uwe Martin; Brincks, John; Christensen, Marie Ernst

doi:10.1016/j.msard.2018.08.017

Cited by 19 publications

(12 citation statements)

References 39 publications

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“…Individuals who had higher intake of whole grains and dairy had less disability; this would seem to favor the Swank diet which includes these food groups over the Wahls™ diet which excludes them. A 2018 systematic review concluded that additional research is needed to determine the effect of diet on MS-related fatigue [261].…”

Section: Comparison Of Swank and Wahlselim Dietsmentioning

confidence: 99%

Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic

2019

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The precise etiology of multiple sclerosis (MS) is unknown but epidemiologic evidence suggests this immune-mediated, neurodegenerative condition is the result of a complex interaction between genes and lifetime environmental exposures. Diet choices are modifiable environmental factors that may influence MS disease activity. Two diets promoted for MS, low saturated fat Swank and modified Paleolithic Wahls Elimination (WahlsElim), are currently being investigated for their effect on MS-related fatigue and quality of life (NCT02914964). Dr. Swank theorized restriction of saturated fat would reduce vascular dysfunction in the central nervous system (CNS). Dr. Wahls initially theorized that detailed guidance to increase intake of specific foodstuffs would facilitate increased intake of nutrients key to neuronal health (Wahls™ diet). Dr. Wahls further theorized restriction of lectins would reduce intestinal permeability and CNS inflammation (WahlsElim version). The purpose of this paper is to review the published research of the low saturated fat (Swank) and the modified Paleolithic (Wahls™) diets and the rationale for the structure of the Swank diet and low lectin version of the Wahls™ diet (WahlsElim) being investigated in the clinical trial.

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Section: Comparison Of Swank and Wahlselim Dietsmentioning

confidence: 99%

Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic

2019

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“…EEG-TMS, non-invasive brain stimulation) in the same sample to obtain multiparametric data; ii) investigating patients at different stages of disease (CIS, advanced progressive MS); iii) assessing whether thalamic impairment is primary or secondary to the damage of other structures outside of the thalamus (e.g., diffuse white matter damage) with a longitudinal design; iv) considering separately different thalamic nuclei and their connections; v) evaluating possible factors that contribute to fatigue pathogenesis and/or exacerbate its manifestations and perception (demographics, comorbidity, genetics, diet, exercise, depression, cognitive impairment, pain and sleep disorders). [60][61][62][63] The management of fatigue requires a multidisciplinary approach including both pharmacological and non-pharmacological interventions, but the evidence supporting their efficacy is still preliminary. Result heterogeneity could be due to methodological differences among studies in terms of sample (e.g., disease duration), and definition of fatigue, with very few studies including neuroimaging protocols.…”

Section: Conclusion Limitations and Future Researchmentioning

confidence: 99%

“…diffuse white matter damage) with a longitudinal design; (4) considering separately different thalamic nuclei and their connections; and (5) evaluating possible factors that contribute to fatigue pathogenesis and/or exacerbate its manifestations and perception (demographics, comorbidity, genetics, diet, exercise, depression, cognitive impairment, pain, and sleep disorders). 62–65…”

Section: Conclusion Limitations and Future Researchmentioning

confidence: 99%

Fatigue in multiple sclerosis: The role of thalamus

et al. 2019

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Fatigue is very common in multiple sclerosis (MS) and is often considered as its most disabling symptom. Over the last 20 years, an increasing number of studies have evaluated the pathogenetic bases of MS-related fatigue. Converging evidence from neurophysiology and neuroimaging research suggests that a dysfunction in a cortico-subcortical pathway, centered on thalamus, is involved in the pathogenesis of fatigue. However, type and significance of such dysfunction remain unknown, and some studies reported an increase in the activity and connectivity within the thalamic network, whereas others suggested its reduction. Hereby, we review the results of neuroimaging studies supporting the different hypotheses about the role of thalamic network in the pathophysiology of MS-related fatigue and discuss limitations and shortcomings of available data, highlighting the key challenges in the field and the directions for future research.

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“…Pommerich et al have suggested a starchy plant-based, low-fat diet, excluding fish and vegetables oils, or a modified Paleo diet for less fatigue. [ 24 ] Healthier lifestyle and higher hydration level have been negatively correlated with fatigue. [ 20 ] Normal body mass index also reduced MS-F compared to being obese or overweight.…”

Section: Risk Factors and Correlated Comorbiditiesmentioning

confidence: 99%

Multiple sclerosis-related fatigue lacks a unified definition

Adibi

Sanayei

Tabibian

et al. 2022

Journal of Research in Medical Sciences

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Fatigue is the most common symptom in multiple sclerosis (MS). Although MS-related fatigue (MS-F) strongly affects quality of life and social performance of patients, there is currently a lack of knowledge about its pathophysiology, which in turns leads to poor objective diagnosis and management. Recent studies have attempted to explain potential etiologies as well as treatments for MS-F. However, it seems that without a consensus on its nature, these data could not provide a route to a successful approach. In this Article, we review definitions, epidemiology, risk factors and correlated comorbidities, pathophysiology, assessment methods, neuroimaging findings, and pharmacological and nonpharmacological treatments of MS-F. Further studies are warranted to define fatigue in MS patients more accurately, which could result in precise diagnosis and management.

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Is there an effect of dietary intake on MS-related fatigue? – A systematic literature review

Cited by 19 publications

References 39 publications

Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic

Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic

Fatigue in multiple sclerosis: The role of thalamus

Multiple sclerosis-related fatigue lacks a unified definition

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