Is there an entero‐hepatic circulation of the bile phospholipids?

Boucrot, P

doi:10.1007/bf02532645

Cited by 34 publications

(12 citation statements)

References 13 publications

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“…All these observations would suggest the existence of an entero-hepatic cycle of biliary phospholipids in sheep intestine similar to that found by Boucrot (1972) in rats.…”

supporting

confidence: 82%

Intestinal absorption and secretion of total and lipid phosphorus in adult sheep fed chopped meadow hay

Thewis¹,

François²

1985

Reprod. Nutr. Dévelop.

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Summary. The flow of total (P T ) and lipid (Pp d phosphorus was measured in adult sheep fed meadow hay and fitted with Ivan-Johnston reentrant cannulas in the duodenum (just posterior to the entry of the common bile and pancreatic duct) and in the terminal ileum.The pattern of plasma, duodenal and ileal P T and P PL specific radioactivity was also studied.The considerable total and lipid P secretion observed between the mouth and the duodenal cannula could be accounted for by salivary and biliary secretions, respectively. This secretion was followed by high absorption in the small intestine and less in the large intestine.A comparison of P specific radioactivities showed that the selective P PL reabsorption occurring in the small intestine could be due to the existence of an entero-hepatic cycle of biliary phospholipids.Introduction.

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“…All these observations would suggest the existence of an entero-hepatic cycle of biliary phospholipids in sheep intestine similar to that found by Boucrot (1972) in rats.…”

supporting

confidence: 82%

Intestinal absorption and secretion of total and lipid phosphorus in adult sheep fed chopped meadow hay

Thewis¹,

François²

1985

Reprod. Nutr. Dévelop.

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“…In a recent study Harrison & Leat (1972) stressed the importance of lysolecithin for fatty acid absorption in the sheep. However, in the rat, there is evidence that biliary lecithin, in contrast to lecithin from other sources, has special properties making it resistant to the action of pancreatic lecithinase (Boucrot, 1972). This question requires further study, particularly in the light of the divergent findings in the human being (Borgstr6m, 1957).…”

Section: Possible Mechanism Ofaction Of Lecithinmentioning

confidence: 99%

The effect of lecithin on intestinal cholesterol uptake by rat intestine in vitro

Rampone¹

1973

The Journal of Physiology

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SUMMARY1. Sacs 20 cm long were obtained from the upper half of the small intestine of bile fistula rats (bile duct cannulated 48 hours previously). The sacs were everted, filled with oxygenated phosphate buffer and incubated 1 hr at 37"Cin 25 ml. of a buffered micellar solution of oleic acid (0.6 mM), mono-olein (0.3 mM), sodium taurocholate (4.8 mM) and 3H-labelled cholesterol (0-15 mM) plus glucose (28 mM 3. Adding 3 ml. whole rate bile with other factors unchanged caused cholesterol uptake to decrease by 50 % in confirmation of previous studies.4. Adding purified lecithin obtained from rat liver tissue, and from egg yolks, similarly decreased cholesterol uptake. A significant response was obtained with 2-5 mg liver lecithin (concentration 0-13 mM) and a near maximum response with 15 mg (concentration 0-80 mM). 10 mg lecithin decreased uptake by an amount equivalent to that obtained with 3 ml. whole bile.5. Lecithin is an active component of whole bile causing reduced intestinal cholesterol uptake from micelles.6. The decreased uptake of cholesterol in the presence of lecithin may have been the result of expansion of the cholesterol-containing micelles with consequent reduction in cholesterol permeability.

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“…PL mass was calculated from the amount of P x 25. The PC were separated by TLC and their fatty acid composition was determined by GLC (Boucrot, 1972). Total bile acid concentration was ascertained by hydroxysteroid dehydrogenase (Talalay, 1960) using purified enzyme obtained from Worthington Biochemical Corporation.…”

Section: Introductionmentioning

confidence: 99%