Is there an impatience genotype leading to non-adherence to long-term therapies?

Réach, G.

doi:10.1007/s00125-010-1755-3

Cited by 25 publications

(13 citation statements)

References 41 publications

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“…Inversely, nonadherence is very frequent in teenagers27 and may simply represent one of the manifestations of disobedience that is a normal characteristic of this period of life, together with teenagers’ difficulty projecting themselves in the future 28. In an even more speculative mode, in the same way that the patience of individuals that leads to adherence24 may be, in part, genetically determined29 and only fully developed in adulthood30 (which may explain why adherence improves with age),13,31–37 similar hypotheses may be proposed for obedience.…”

Section: Discussionmentioning

confidence: 99%

Obedience and motivation as mechanisms for adherence to medication: a study in obese type 2 diabetic patients

Réach¹

2011

PPA

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ObjectiveTo clarify the mechanisms of adherence.MethodsA cross-sectional, multicenter French study using a self-questionnaire administered by 116 general practitioners to 782 obese type 2 diabetic patients.ResultsThe analysis of 670 completed questionnaires revealed a strong association between the adherence to medication and the behavior of fastening the seatbelt when seated in the rear of a car. Multivariate analysis indicated that this behavior was an independent determinant of adherence to medication (odds ratio [OR] 2.3, 95% confidence interval [CI] 1.4–3.6, P < 0.001) with the same OR as the motivation to adhere to medical prescriptions (OR 2.2, 95% CI 1.3–3.6, P = 0.003) in a model with good accuracy (area under the receiver operating characteristic curve 0.774). A multiple correspondence analysis suggested that adherence to medication and seatbelt behavior are “homologous” behaviors, with homology between phenomena defined by the fact that they share a common etiology.ConclusionAdherence may have two dimensions: passive (obedience, the main determinant of seatbelt behavior) and active (motivation). This conclusion has theoretical and practical implications. Firstly, empowerment through patient education can be defined as a process that replaces the passive mechanism of adherence in patients’ minds with an active, conscious choice. Secondly, recognizing these two dimensions may help to establish a tailored patient-physician relationship to prevent nonadherence.

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Section: Discussionmentioning

confidence: 99%

Obedience and motivation as mechanisms for adherence to medication: a study in obese type 2 diabetic patients

Réach¹

2011

PPA

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“…The theory of neuroeconomics, an emerging field of study focusing on anomalies in the classical economics rationale, can provide important clues for understanding unreasonable human behavior regarding decisions over outcomes that occur at different time points 6,7. Neuroeconomic studies have demonstrated that humans and animals prefer rewards available to them in the short term over rewards only available in the long term.…”

Section: Introductionmentioning

confidence: 99%

A socioeconomic and behavioral survey of patients with difficult-to-control type 2 diabetes mellitus reveals an association between diabetic retinopathy and educational attainment

Emoto¹,

Okajima²,

Sugihara³

et al. 2016

PPA

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BackgroundWe have recently reported that the attitude of patients toward risk could be a factor in the progression of diabetic complications. In general, risk preference is closely related to socioeconomic status (SES), which includes factors such as age, sex, income, and educational attainment.ObjectiveWe aimed to determine the effect of SES and behavioral propensity on the progress of diabetic complications in patients with type 2 diabetes mellitus (T2DM).MethodsWe conducted a survey of 238 patients with difficult-to-control T2DM treated at a hospital in Japan using a modified behavioral economics questionnaire that included questions related to SES. The patients had been referred by general practitioners or other departments in the hospital because of poor metabolic control or unstable complications.ResultsEducational attainment was significantly associated with progression of retinopathy in patients <65 years of age. Educational attainment of a high school diploma (12 years of education) or lower was a significant risk factor, but there were no differences among levels of attainment beyond high school (13–16 years or more of education). Behavioral propensities were also weakly associated with complications, but not as much as educational attainment. Personal income level and economic status did not show an association with the retinopathy levels.ConclusionLower educational attainment is a strong risk factor for diabetic retinopathy, and it is independent of the economic status. The result suggests that cognitive function may play an important role in the progression of diabetic retinopathy in patients with T2DM.

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“…The cause of nonadherence is complex and there are many factors that have been linked to increasing rates of nonadherence. These include factors related to the cost of the medications, socioeconomic status, and convenience . With increasing rates of poverty among those living in rural areas, overall lower median household income for rural dwellers compared to urban dwellers, reduced rates of insurance coverage for rural dwellers, and increased distance to health care services among individuals living in rural communities, one would assume the risk of nonadherence is increased among those living in rural communities …”

mentioning

confidence: 99%

“…These include factors related to the cost of the medications, socioeconomic status, and convenience. [10][11][12][13][14][15] With increasing rates of poverty…”

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confidence: 99%

Evaluating Factors Impacting Medication Adherence Among Rural, Urban, and Suburban Populations

Arbuckle

Tomaszewski

Aronson

et al. 2018

The Journal of Rural Health

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Disclosures: Donald Morisky receives a royalty for use of the copyrighted and trademarked MMAS-8. Funding: Jon Schommer received The PetersInstitute in Pharmacy Practice Innovation, Endowed Chair Award, which was used to fund this project. Findings: Overall adherence rates did not differ significantly between rural and urban adults with average adherence based on MMAS-8 scores of 5.58 and 5.64, respectively (P = .253). Age, income, education, male sex, and white race/ethnicity were associated with higher adherence rates. While the overall adherence rates between urban and rural adults were not significantly different, the factors that influenced adherence varied between age-specific population density groupings. Conclusion:These analyses suggest that there is no significant difference in adherence between rural and urban populations; however, the factors contributing to medication adherence may vary based on age and population density. Future adherence intervention methods should be designed with consideration for these individualized factors.Key words access to care, health care access, medication adherence, medication use, pharmacy.Medication nonadherence is considered one of the greatest modifiable health risks to exist in the United States. Nearly half of all Americans who are prescribed a prescription medication are nonadherent to it. 1 The presence of nonadherence to prescription medications causes poor health-related outcomes. Nonadherence has been shown to increase the likelihood of disease progression, lead to higher utilization of health care services, increase the cost of care, and cause higher mortality rates. 2-9The cause of nonadherence is complex and there are many factors that have been linked to increasing rates of nonadherence. These include factors related to the cost of the medications, socioeconomic status, and convenience. [10][11][12][13][14][15] With increasing rates of poverty

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Is there an impatience genotype leading to non-adherence to long-term therapies?

Cited by 25 publications

References 41 publications

Obedience and motivation as mechanisms for adherence to medication: a study in obese type 2 diabetic patients

Obedience and motivation as mechanisms for adherence to medication: a study in obese type 2 diabetic patients

A socioeconomic and behavioral survey of patients with difficult-to-control type 2 diabetes mellitus reveals an association between diabetic retinopathy and educational attainment

Evaluating Factors Impacting Medication Adherence Among Rural, Urban, and Suburban Populations

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