This paper extends a two-period Overlapping Generations model of endogenous growth where the interactions between public infrastructure and human capital with R&D activities, and growth are studied. The paper makes two important contributions. First, it accounts for the spillover e¤ect of the stock of ideas on learning which in turn promotes the production of innovative technologies. In doing so, it brings to the fore a two-way interaction between human capital and innovation. The paper then applies various econometric methods, which con…rm the above theoretical thesis. Second, the solutions of the model emphasise the important role public spending on infrastructure, human capital and R&D can play in promoting economic growth. However, the …ndings also show that trade-o¤s in the allocation of public spending may inevitably emerge. In particular, investment in public infrastructure at the expense of spending on R&D is less likely to succeed in promoting economic growth, whereas it may be more e¤ective to foster growth through an o¤setting cut in another productive component, namely, education. In light of these potential trade-o¤s, governments in low-income countries need to use their limited budgets as part of holistic measures in order to achieve e¢ cient outcomes.