Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia?

Abstract

BackgroundThe aim of the present study was to investigate the cardioprotective effect of Taurine on the donor hearts during cold ischemic period.Methods32 rats were divided into four groups (sham, taurine, ischemia, treatment group, 8 rats in each). All rats were fed with rat food for three weeks. Taurine and treatment groups were given a 200 mg/kg/day dose of Taurine by oral gavage besides rat feed. Cardiectomy was performed in all rats after three weeks. In ischemia and treatment groups, harvested hearts were kept in 0.9% sodium chloride at +4 degrees C for 5 hours. Tissue samples were taken from left ventricle in all groups. These samples were evaluated by histopathologic and biochemical examination.ResultsIn the present study results of the biochemical and histopathological examination reveals the protective effects of Taurine. As a marker of lipid peroxidation, Malondialdehyde (MDA) levels in ischemia group were significantly higher than both Sham and Taurine groups. MDA values were recorded; 3.62 ± 0.197 in the sham group, 2.07 ± 0.751 in the Taurine group, 9.71 ± 1.439 in the ischemia group and 7.68 ± 1.365 in the treatment group. MDA levels decreased in treatment group. (p < 0.05) In accordance with MDA findings, while superoxide dismutase and glutathione peroxidase levels decreased in ischemia group, they increased in treatment group. (p < 0.05) There was no differences in Catalase (CAT) enzyme level between treatment and ischemia group (p = 1.000). CAT level results were recorded; 7.08 ± 0.609 in the sham group, 6.15 ± 0.119 in the Taurine group, 5.02 ± 0.62 in the ischemia group, and 5.36 ± 0.384 in the treatment group. Less intracellular edema and inflammatory cell reaction were observed in histologic examination in favor of treatment group. (p < 0.01)ConclusionTaurine decreased myocardial damage during cold ischemic period following global myocardial ischemia.

Vasopressin attenuates ischemia–reperfusion injury via reduction of oxidative stress and inhibition of mitochondrial permeability transition pore opening in rat hearts

“…Increased free oxygen radicals cause tissue damage through the peroxidation of the lipids present in the cell membranes and increasing lipid peroxidation might be used as a sign of the tissue damage. MDA is the final product of lipid peroxidation and is used as an indicator of tissue damage caused by oxygen free radicals (Kim et al, 2000;Molina and Garcia, 1997;Sahin et al, 2011). Current data show that plasma level of MDA significantly reduced following exogenous administration of AVP compared to control group moreover caused decrease of the PAB value in favor of the antioxidant status and Atractyloside in AVPþAtr group significantly increased PAB value and returned its level to oxidant status as seen as in control group.…”

Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase

“…A general problem in organ transplantations is to protect the explanted organ against ischemic damage. However, explanted hearts from rats treated with increased dietary taurine intake have shown to be significantly more resistant to ischemic damage (58). Addition of 10 mM taurine to the St. Thomas' cardioplegic solution, used to store transplanted hearts during transplantation surgery, significantly improved preservation of the heart by lowering DNA oxidative stress and apoptosis (48).…”

“…Taurine together with other free amino acids is released during ischemia (24), and anion channel blockers including DIDS partially reduce the ischemia-induced amino acid release (59), indicating that VSOAC may be involved in taurine release. Explanted hearts from rats fed on a diet with high taurine content showed increased resistance to ischemic damage (58). Furthermore, storage of fresh rat hearts in a solution with taurine significantly improved preservation of the rat hearts by lowering DNA oxidative stress and apoptosis (48).…”

Taurine: a critical nutrient for future fish feeds

“…Taurine has been linked to a number of health benefits, including tissue repair (Gupta et al, 2006;Kingston et al, 2004;Motawi et al, 2007;Sahin et al, 2011;Seki et al, 2005;Shiny et al, 2005;Takatani et al, 2004;Tong et al, 2006;Zhang et al, 2008;Zhang et al, 2010), alleviation of metal toxicity (Aydogdu et al, 2007;Bosgelmez and Guvendik, 2004;Bosgelmez et al, 2008;Gulyasar et al, 2010;Gurer et al, 2001) and bacterial lipopolysaccharide hepatotoxicity (Kim and Kim, 2002). Many of these actions result from two, cascading mechanisms.…”